Person:
González Burgos, Elena María

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First Name
Elena María
Last Name
González Burgos
URI
https://hdl.handle.net/20.500.14352/77699
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Farmacología, Farmacognosia y Botánica
Area
Farmacología
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UCM identifierORCIDScopus Author IDWeb of Science ResearcherIDDialnet IDGoogle Scholar ID

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2010 - 201912020 - 20212
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Now showing 1 - 3 of 3
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    HPLC isolation of antioxidant constituents from Xanthoparmelia spp
    (Journal of Pharmaceutical and Biomedical Analysis, 2010) Amo De Paz, Guillermo; Raggio Quílez, José; Gómez-Serranillos Cuadrado, María Pilar; Palomino Ruiz-Poveda, Olga María; González Burgos, Elena María; Carretero Accame, María Emilia; Crespo De Las Casas, Ana María
    A chromatographic method is described for the purification and characterization of secondary lichen substances with biological activity. A simple reversed-phase high-performance liquid chromatography method with gradient elution has been developed that allows the determination and isolation of salazinic, usnic and stictic acids from lichen samples in a single run and the quantification of every acid in the tested extracts. The antioxidant activity of both the isolated compounds and the respective lichen belonging to Xanthoparmelia genus was determined by the Oxygen Radical Absorbance Capacity (ORAC) assay; their effect as free radical scavengers, effect on cell survival by the 3(4,5-dimethyltiazol-2-yl)-2,5-diphenyltetrazolium reduction assay and 2′,7′-dichlorofluorescin diacetate method were tested on U373 MG human astrocytome cell line. Both lichens extracts and all isolated compounds protected U373 MG cells from hydrogen peroxide-induced damage, suggesting that they could act as antioxidant agents in those neurodegenerative disorders associated with oxidative damage, such as Alzheimer's disease and Parkinson's disease.
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    Effect of Phenolic Compounds on Human Health
    (Nutrients, 2021) González Burgos, Elena María; Gómez-Serranillos Cuadrado, María Pilar
    The consumption of exogenous medicinal plants and food rich in phenolic compounds represents a promising therapeutically to prevent many chronic diseases, including diabetes, cardiovascular diseases, cancer, and neurodegenerative diseases, among others.
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    Nutritional Value of Moringa oleifera Lam. Leaf Powder Extracts and Their Neuroprotective Effects via Antioxidative and Mitochondrial Regulation
    (Nutrients, 2021) González Burgos, Elena María; Ureña Vacas, Isabel María; Sánchez Gómez-Serranillos, Marta; Gómez-Serranillos Cuadrado, María Pilar
    Age-related neurodegenerative disorders are an increasing public health problem. Oxidative stress is one of the major causes. Medicinal plant-based functional foods can be effective for these diseases. The aim of this work is to investigate the neuroprotective role of methanol extracts of Moringa oleifera leaf powder on antioxidant/oxidant imbalance and mitochondrial regulation in a H2O2-induced oxidative stress model in human neuroblastoma cells. On nutritional analysis, results showed that moringa contained 28.50% carbohydrates, 25.02% proteins, 10.42% fat, 11.83% dietary fiber, 1.108 mg β-carotene, 326.4 µg/100 g vitamin B1 and 15.2 mg/100 g vitamin C. In-vitro assays revealed that moringa methanol extracts had more phenolic content and higher antioxidant activity than acetone extracts. Moreover, pretreatments with methanol extracts showed a protective effect against H2O2-induced oxidative damage through increasing cell viability and reducing free radicals. Furthermore, the extract decreased lipid peroxidation and enhanced glutathione levels and antioxidant enzyme activity. Finally, moringa also prevented mitochondrial dysfunction by regulating calcium levels and increasing mitochondrial membrane potential. The most active concentration was 25 µg/mL. In summary, the nutritional and functional properties of Moringa oleifera as a neuroprotective agent could be beneficial to protect against oxidative stress and provide necessary nutrients for a healthy diet.