Person:
Martín Carmona, María Antonia

First Name

María Antonia

Last Name

Martín Carmona

URI

https://hdl.handle.net/20.500.14352/77618

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Farmacia

Department

Química en Ciencias Farmacéuticas

Area

Química Analítica

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SPE/RP-HPLC using C1 columns: an environmentally friendly alternative to conventional reverse-phase separations for quantitation of beta-carboline alkaloids in human serum samples
(Analytical and Bioanalytical Chemistry, 2010) González-Ruiz, Víctor; Olives Barba, Ana Isabel; Martín Carmona, María Antonia
A fluorescent styrylquinoline with combined therapeutic and diagnostic activities against alzheimer’s and prion diseases
(ACS Medicinal Chemistry Letters, 2013) Staderini, Matteo; Aulić, Suzana; Bartolini, Manuela; Tran, Hoang Ngoc Ai; González-Ruiz, Víctor; Pérez, Daniel I.; Martínez Gil, Ana; Andrisano, Vincenza; Legname, Giuseppe; Menéndez Ramos, José Carlos; Bolognesi, Maria Laura; Cabezas Baudot, Nieves; Martín Carmona, María Antonia
(E)-6-Methyl-4′-amino-2-styrylquinoline (3) is a small molecule with the proper features to potentially diagnose, deliver therapy and monitor response to therapy in protein misfolding diseases. These features include compound fluorescent emission in the NIR region and its ability to interact with both Aβ and prion fibrils, staining them with high selectivity. Styrylquinoline 3 also inhibits Aβ self-aggregation in vitro and prion replication in the submicromolar range in a cellular context. Furthermore, it is not toxic and is able to cross the blood brain barrier in vitro (PAMPA test).

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Person: Martín Carmona, María Antonia

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Person:
Martín Carmona, María Antonia