Person: Gómez Mejía, Esther
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First Name
Esther
Last Name
Gómez Mejía
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Analítica
Area
Identifiers
7 results
Search Results
Now showing 1 - 7 of 7
- Project number: 202
Item ODS con mucha ciencia: Hacia una enseñanza STEM y más allá(2022) Gracia Lor, Emma; Blanco Asenjo, Miriam; Espada Bernabé, Elena; Fernández Bautista, Tamara; Gómez Castro, Emilio; Gómez Mejía, Esther; Gómez Gómez, Beatriz; Lorente Arévalo, Álvaro; Moreno Martín, Gustavo; Muñoz Olivas, María Riansares; Muñoz San Martín, Cristina; Oro Carretero, Paloma de; Pérez Corona, María Teresa; Romero Sánchez, Iván; Sacristán Navarro, Iván; Vicente Zurdo, DavidMemoria del proyecto de innovación titulado "ODS con mucha ciencia: Hacia una enseñanza STEM y más allá" de la convocatoria 2021-2022. El proyecto se ha centrado en fomentar el interés de los estudiantes de ESO y Bachillerato por la ciencia, proporcionándoles herramientas para que desarrollen competencias STEM a través de charlas de divulgación, talleres experimentales y sesiones de mentoría. Item A Comprehensive Analytical Review of Polyphenols: Evaluating Neuroprotection in Alzheimer’s Disease(International Journal of Molecular Sciences, 2024) Vicente Zurdo, David; Gómez Mejía, Esther; Rosales Conrado, Noelia; León González, María Eugenia DeAlzheimer’s Disease (AD), a prevalent neurodegenerative disorder, is the primary cause of dementia. Despite significant advancements in neuroscience, a definitive cure or treatment for this debilitating disease remains elusive. A notable characteristic of AD is oxidative stress, which has been identified as a potential therapeutic target. Polyphenols, secondary metabolites of plant origin, have attracted attention due to their potent antioxidant properties. Epidemiological studies suggest a correlation between the consumption of polyphenol-rich foods and the prevention of chronic diseases, including neurodegenerative disorders, which underscores the potential of polyphenols as a therapeutic strategy in AD management. Hence, this comprehensive review focuses on the diverse roles of polyphenols in AD, with a particular emphasis on neuroprotective potential. Scopus, ScienceDirect, and Google Scholar were used as leading databases for study selection, from 2018 to late March 2024. Analytical chemistry serves as a crucial tool for characterizing polyphenols, with a nuanced exploration of their extraction methods from various sources, often employing chemometric techniques for a holistic interpretation of the advances in this field. Moreover, this review examines current in vitro and in vivo research, aiming to enhance the understanding of polyphenols’ role in AD, and providing valuable insights for forthcoming approaches in this context.Item Screening the extraction process of phenolic compounds from pressed grape seed residue: Towards an integrated and sustainable management of viticultural waste(LWT - Food Science and Technology, 2022) Gómez Mejía, Esther; Vicente Zurdo, David; Rosales Conrado, Noelia; León González, María Eugenia; Madrid Albarrán, YolandaThe integrated valorisation of waste from the food chain to obtain value-added compounds with biological functionality will facilitate the transition to the era of a sustainable bioeconomy. To this end, an efficient matrix solid-phase dispersion (MSPD) extraction method was developed and optimized, using experimental factorial design and response surface methodology, for polyphenols recovery from pressed grape seeds obtained after the extraction of essential oils by cold pressing. Gallic, dihydroxybenzoic, p-coumaric and trans-ferulic acid, naringin, resveratrol, quercetin and kaempferol were quantified at 2.1–295 μg g−1 by capillary liquid chromatography coupled to a diode array detector and a mass analyser (cLC-DAD-MS). Furthermore, total antioxidant activity, free radical scavenging and lipid peroxidation suppression, together with the inhibition of beta-amyloid (Αβ42) protein aggregation, considered one of the main pathological effects of Alzheimer's disease, were evaluated. Potent lipid peroxidation inhibition (IC50 0.238 ± 0.003 ng g−1) was observed, along with the reduction of Αβ42 fibril width (9.4–54.8%) and aggregation. The results presented proved that the MSPD extraction method could be considered as an efficient and sustainable methodology to produce phenolic-rich extracts that may serve as an alternative antioxidant and neuroprotective ingredient for the food or pharmaceutical formulations, leading to the cascade valorisation of winery by-products.Item Aprendizaje-Servicio para trasladar los resultados desarrollo sostenible: del laboratorio a la sociedad(2021) Gracia Lor, Emma; Gómez Mejía, Esther; Moreno Martín, Gustavo; Gómez Gómez, Beatriz; Vicente Zurdo, David; Pérez Corona, María Teresa; Muñoz Olivas, María Riansares; Gómez Castro, EmilioEl objetivo general planteado en este proyecto ha sido comunicar y concienciar a los estudiantes de secundaria y bachillerato sobre la necesidad de un desarrollo sostenible, con el fin de que sean capaces de comprender e identificar las problemáticas asociadas a los objetivos planteados en la Agenda 2030 y asociarlas con actividades propias de la vida cotidiana. De esta manera, los alumnos podrán adquirir herramientas de gran utilidad para el desarrollo de su futura vida personal y profesional. Para lograr dichos objetivos se han llevado a cabo una serie de actividades (charlas de divulgación científica, debates, uso de la aplicación Kahoot) en diferentes centros educativos no universitarios, en concreto, en tres institutos de educación secundaria y bachillerato (IES) y en un centro de educación de personas adultas (CEPA). Los temas tratados se encuadran dentro de los Objetivos de Desarrollo Sostenible (ODS) de la Agenda 2030, concretamente los ODS 2, 3 y 12.- Project number: 283
Item La divulgación científica como herramienta para promover el desarrollo sostenible: de la universidad a la sociedad(2021) Gracia Lor, Emma; Muñoz Olivas, María Riansares; Pérez Corona, María Teresa; Gómez Castro, Emilio; Gómez Mejía, Esther; Moreno Martín, Gustavo; Vicente Zurdo, David; Gómez Gómez, BeatrizMemoria del proyecto de innovación titulado "La divulgación científica como herramienta para promover el desarrollo sostenible: de la universidad a la sociedad" de la convocatoria 2020-2021. El proyecto se ha centrado en promover una educación de calidad mediante la transferencia de conocimientos científicos relacionados con los Objetivos de Desarrollo Sostenible 2, 3 y 12 de la Agenda 2030 y el desarrollo de pensamiento crítico científico-divulgativo tanto del alumnado procedente de centros educativos de secundaria y bachillerato como de los estudiantes de universidad. Item Neuroprotective activity of selenium nanoparticles against the effect of amino acid enantiomers in Alzheimer’s disease(Analytical and Bioanalytical Chemistry, 2022) Vicente Zurdo, David; Rodríguez-Blázquez, Sandra; Gómez Mejía, Esther; Rosales Conrado, Noelia; León González, María Eugenia De; Madrid Albarrán, María YolandaAlzheimer’s disease (AD), the most prevalent neurodegenerative disease, is characterized by extracellular accumulation of amyloid-beta protein (Aβ), which is believed to be the very starting event of AD neurodegeneration. In this work, D-Phe, D-Ala, and D-Glu amino acids, which are the non-occurring enantiomeric form in the human body, and also D-Asp and DL-SeMet, have proved to be amyloidogenic regarding Aβ42 aggregation in TEM studies. These amyloidogenic amino acid enantiomers also widened Aβ42 fibrils up to 437% regarding Aβ42 alone, suggesting that Aβ42 aggregation is enantiomerically dependent. To inhibit enantiomeric-induced amyloid aggregation, selenium nanoparticles stabilized with chitosan (Ch-SeNPs) were successfully synthesized and employed. Thus, Ch-SeNPs reduced and even completely inhibited Aβ42 aggregation produced in the presence of some amino acid enantiomers. In addition, through UV–Vis spectroscopy and fluorescence studies, it was deduced that Ch-SeNPs were able to interact differently with amino acids depending on their enantiomeric form. On the other hand, antioxidant properties of amino acid enantiomers were evaluated by DPPH and TBARS assays, with Tyr enantiomers being the only ones showing antioxidant effect. All spectroscopic data were statistically analysed through experimental design and response surface analysis, showing that the interaction between the Ch-SeNPs and the amino acids studied was enantioselective and allowing, in some cases, to establish the concentration ratios in which this interaction is maximum.Item The potential of plum seed residue: unraveling the effect of processing on phytochemical composition and bioactive properties(International Journal of Molecular Science, 2024) Rodríguez-Blázquez, Sandra; Pedrera-Cajas, Laura; Gómez Mejía, Esther; Vicente Zurdo, David; Rosales Conrado, Noelia; León González, María Eugenia De; Rodríguez Bencomo, Juan José; Miranda Carreño, RubénBioactive compounds extracted from plum seeds were identified and quantified, aiming to establish how the brandy manufacturing process affects the properties and possible cascade valorization of seed residues. Extraction with n-hexane using Soxhlet has provided oils rich in unsaturated fatty acids (92.24–92.51%), mainly oleic acid (72–75.56%), which is characterized by its heart-healthy properties. The fat extracts also contain tocopherols with antioxidant and anti inflammatory properties. All the ethanol–water extracts of the defatted seeds contain neochlorogenic acid (90–368 µg·g−1), chlorogenic acid (36.1–117 µg·g −1), and protocatechuate (31.8–100 µg·g−1) that have an impact on bioactive properties such as antimicrobial and antioxidant. Anti-amyloidogenic activity (25 mg·mL−1) was observed in the after both fermentation and distillation extract, which may be related to high levels of caffeic acid (64 ± 10 µg·g −1m). The principal component analysis showed that all plum seed oils could have potential applications in the food industry as edible oils or in the cosmetic industry as an active ingredient in anti-aging and anti-stain cosmetics, among others. Furthermore, defatted seeds, after both fermentation and distillation, showed the greatest applicability in the food and nutraceutical industry as a food supplement or as an additive in the design of active packaging.