Person: Pérez Carrasco, María Jesús
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First Name
María Jesús
Last Name
Pérez Carrasco
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Óptica y Optometría
Department
Optometría y Visión
Area
Optica
Identifiers
10 results
Search Results
Now showing 1 - 10 of 10
Item Effect of a yellow filter on mesopic contrast perception and differential light sensitivity in the visual field.(Ophthalmic Research, 2003) Pérez Carrasco, María Jesús; Puell Marín, María Cinta; Sánchez Ramos, Celia; Langa Moraga, AntonioPurpose: Previous studies on the effects of yellow filters in the visual performance have been carried out, presenting discrepancies among the different investigations. Our study reports the influence of the yellow filter without residual reflections on contrast perception and differential light sensitivity (DLS) under mesopic conditions. Methods: Contrast sensitivity, low contrast visual acuity and luminance thresholds in the central visual field (30 degrees ) were measured in a group of 38 adult subjects with and without a coated yellow lens (482-nm cut-off) under mesopic conditions. Results: The contrast sensitivity mean was significantly better with the filter at low- and middle-range spatial frequencies (1.5 cycles/degree p = 0.002 and 6 cycles/degree p = 0.02). At 5% contrast, the mesopic low contrast visual acuity improved significantly (p = 0.004) when interposing the yellow filter. The increase in DLS was statistically significant [e.g. all visual fields p = 0.0003 and macular visual field (9.5 degrees ) p = 0.00001] through the yellow filter on the different established areas of the visual field (30 degrees ). Conclusions: The yellow filter without residual reflections had a positive influence on the brightness and contrast perception of healthy subjects, for which its use would be beneficial under mesopic conditions.Item Nuevo instrumento para medir la sensibilidad al contraste sin y con deslumbramiento(Archivos de la Sociedad Española de Oftalmología, 2003) Sánchez Ramos, Celia; Puell Marín, María Cinta; Pérez Carrasco, María Jesús; Langa Moraga, Antonio; Benítez Del Castillo Sánchez, José ManuelOBJETIVO/MÉTODO: valorar la sensibilidad al contraste fotópica, sin y con deslumbramiento con un nuevo instrumento. Se estudiaron 78 ojos derechos de 49 adultos jóvenes y de 29 adultos entre 35 y 55 años. La sensibilidad al contraste se midió con el Contrast Glarester CGT-1000 mediante una estrategia automatizada de reconocimiento para seis frecuencias espaciales. RESULTADOS/CONCLUSIONES: Los valores de sensibilidad al contraste fueron semejantes a los obtenidos con otros test clínicos. El aumento de la edad disminuyó significativamente la sensibilidad al contraste sin y con deslumbramiento. Sin embargo, el deslumbramiento no modificó la sensibilidad al contraste fotópica.Item Macular Inner Retinal Layer Thickness in Relation to Photopic and Mesopic Contrast Sensitivity in Healthy Young and Older Subjects(Investigative Ophthalmology & Vision Science, 2018) Puell Marín, María Cinta; Palomo Álvarez, Catalina; Pérez Carrasco, María JesúsPurpose: To examine relationships between the thicknesses of ganglion cell (GC)-related macular layers and central photopic or mesopic contrast sensitivity (CS) in healthy eyes. Methods: Measurements were made in 38 young and 38 older healthy individuals. Total, inner, and outer retinal layer (IRL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT) across three subfields, or rings, centered at the fovea: central foveal, pericentral, and peripheral. Ganglion cell complex and circumpapillary retinal nerve fiber layer thicknesses were also measured. Low-spatial-frequency CS for gratings presented at the central 10° visual field were measured through computerized psychophysical tests under photopic and mesopic conditions. Relationships were examined by uni- and multivariate regression analysis. Results: Peripheral IRL thickness emerged as the only independent predictor of photopic CS (P = 0.001) in the young group and of photopic (P = 0.026) and mesopic CS (P = 0.001) in the older group. The slopes of regression lines used to predict CS from peripheral IRL thickness were significantly different for pair-wise comparisons of both photopic CS and age group (P = 0.0001) and mesopic CS (P = 0.0001) and age group. These models explained 37% of the variability in photopic CS and 36% of the variability in mesopic CS. Conclusions: Macular IRL thinning likely due to GC loss was related to reduced photopic and mesopic CS in older healthy eyes. In contrast, in the young eyes, a thicker macular IRL, possibly indicating transient gliosis, was associated with reduced CS.Item Contrast sensitivity and disability glare in patients with dry eye(Acta Ophthalmologica Scandinavica, 2006) Puell Marín, María Cinta; Benítez Del Castillo Sánchez, José Manuel; Martínez De La Casa Fernández-Borrella, José María; Sánchez Ramos, Celia; Aladro Vico, Eva; Pérez Carrasco, María Jesús; Pedraza Aranda, Constanza; Hierro Zarzuelo, Almudena, delPurpose: To evaluate contrast sensitivity and disability glare in patients with dry eye using the Contrast Glaretester 1000. Methods: Contrast sensitivity and disability glare were determined in 33 eyes of 33 patients with dry eye and 30 eyes of 30 healthy control subjects for six target sizes with a visual angle of 6.3-0.7 degrees using the Contrast Glaretester 1000, whose working mechanism is similar to that of the conventional perimetry instrument. Results: Contrast sensitivity was significantly worse in dry eye group when viewing all target sizes (reduction of 0.10-0.25 log contrast units, p < 0.01) except at 6.3 degrees. In the presence of glare, differences in log contrast sensitivity between the groups (0.10-0.25 units) were significant (p < 0.01) for all target sizes, with the dry eye group showing worse results. The reduction in contrast sensitivity induced by glare (disability glare) was significantly worse in the dry eye group versus the control group but only for the 2.5-degree size target, where 0.14 log contrast units were lost. Conclusions: Contrast sensitivity with and without glare was significantly reduced in patients with dry eye compared with control subjects, but the number of log contrast units lost with glare (disability glare) was similar in the two groups, except for the 2.5-degree size target.Item Association between central retinal thickness and low luminance visual acuity in early age-related macular degeneration(European Journal of Ophthalmology, 2020) Puell Marín, María Cinta; Hurtado Ceña, Francisco Javier; Pérez Carrasco, María Jesús; Contreras Martín, InésPurpose/Aim: To examine whether central retinal thickness (CRT) is related to mesopic visual acuity (VA) and low luminance deficit (LLD, difference between photopic and mesopic VA) in eyes with early and intermediate age-related macular degeneration (AMD). Materials and Methods: In a cross-sectional study, 50 pseudophakic subjects older than 63 years were divided into three groups (no AMD, early AMD and intermediate AMD). Spectral domain optical coherence tomography (SD-OCT) was used to measure CRT in the 1 mm-central-area. Best-corrected distance VA was measured under photopic or mesopic luminance conditions and LLD calculated. Subjects were stratified by VA impairment to compare CRTs across these groups. Relationships were examined by stepwise multiple linear regression. Results: No significant differences in mean CRT, photopic and mesopic VA or LLD were detected between the groups no AMD, early AMD and intermediate AMD. However, mean CRTs were 20 microns and 18 microns thicker in the eyes with impaired mesopic VA (> 0.3 logMAR) and impaired LLD (⩾ 0.3 logMAR) compared to the eyes with non-impaired VA or LLD respectively (both p < 0.01). CRT and mesopic pupil size were independent predictors of mesopic VA (p = 0.001). CRT emerged as the only independent predictor of LLD (p = 0.004). Conclusions: Increased CRT was linked to worse retinal function when measured under mesopic conditions in eyes without AMD and eyes with early to intermediate AMD. SD-OCT imaging combined with VA measurements under low luminance conditions could be a useful tool to detect early AMD.Item Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses(Translational vision science & technology, 2021) Pérez Carrasco, María Jesús; Carballo Álvarez, Jesús; Barbur, John L.; Puell Marín, María CintaPurpose: Early detection of structural changes in retinal ganglion cells (RGCs) and corresponding changes in visual function is important in early degenerative diseases of the retina, but the sensitivity of both measurements is limited by the inherent variability in healthy subjects. This study investigates the relationships between RGC-related layer thicknesses and foveal and parafoveal flicker modulation sensitivity (FMS) across photopic and mesopic light levels in healthy subjects. Methods: Photopic and mesopic FMS was measured in 56 young adults, at the point of fixation and at an eccentricity of 5 degrees, in each of the four quadrants. Spectraldomain optical coherence tomography (SD-OCT) was used to measure retinal thicknesses. Relationships between foveal and parafoveal FMS and the retinal thickness in the corresponding region were examined after adjusting for confounding variables. Results: Total macular and inner retinal layer (IRL) thicknesses in the parafoveal ring were significant predictors of photopic (P = 0.034) and mesopic (P = 0.034) parafoveal FMS, respectively. The superior peripapillary retinal nerve fiber layer (pRNFL) thickness was a contributing factor to the inferior parafoveal FMS (photopic: P = 0.006 and mesopic: P = 0.021) and the inferior pRNFL thickness was also a contributing factor to the superior parafoveal FMS (photopic: P < 0.001 and mesopic: P = 0.015). Conclusions: The pRNFL thicknesses predict parafoveal FMS for both mesopic and photopic conditions in healthy eyes. Translational Relevance: Themeasurement of rapid flicker sensitivity in the parafoveal retina together with the pRNFL thickness profiles measured before the onset of disease, may provide a more sensitive biomarker for detecting loss of sensitivity caused by the earliest neurodegenerative changes in the eyes.Item Disk halo size measured in individuals with monofocal versus diffractive multifocal intraocular lenses(Journal of cataract and refractive surgery, 2015) Puell Marín, María Cinta; Pérez Carrasco, María Jesús; Hurtado Ceña, Francisco Javier; Álvarez Rementería Fernández, LaureanoPURPOSE: To compare disk halo size in response to a glare source in eyes with an aspheric apodized diffractive multifocal intraocular lens (IOL) or aspheric monofocal IOL. SETTING: Rementeria Ophthalmological Clinic, Madrid, Spain. DESIGN: Prospective randomized masked study. METHOD: Halo radius was measured using a vision monitor (MonCv3) with low-luminance optotypes in eyes that had cataract surgery and bilateral implantion of an Acrysof Restor SN6AD1 multifocal IOL or Acrysof IQ monofocal IOL 6 to 9 months previously. The visual angle subtended by the disk halo radius was calculated in minutes of arc (arcmin). Patient complaints of halo disturbances were recorded. Monocular uncorrected distance visual acutity (UDVA) and corrected distance visual acuity (CDVA) were measured using high-contrast (96%) and low-contrast (10%) logMAR letter charts. RESULTS: The study comprised 39 eyes of 39 subjects (aged 70 to 80 years); 21 eyes had a multifocal IOL and 18 eyes a monofocal IOL. The mean halo radius was 35 arcmin larger in the multifocal IOL group than the monofocal group (P<.05). Greater halo effects were reported in the multifocal IOL group (P<.05). The mean monocular high-contrast UDVA and low-contrast UDVA did not vary significantly between groups, whereas the mean monocular high-contrast CDVA and low-contrast CDVA were significantly worse at 0.12 logMAR and 0.13 logMAR in the multifocal than in the monofocal IOL group, respectively (P <.01). A significant positive correlation was detected by multiple linear regression between the halo radius and low-contrast UDVA in the multifocal IOL group (r = 0.72, P<.001). CONCLUSIONS: The diffractive multifocal IOL gave rise to a larger disk halo size, which was correlated with a worse low-contrast UDVA.Item Relationship between halo size and forward light scatter(British Journal of Ophthalmology, 2014) Puell Marín, María Cinta; Pérez Carrasco, María Jesús; Palomo Álvarez, Catalina; Antona Peñalba, Beatriz; Barrio De Santos, Ana RosaPurpose -To determine the relationship between the size of a halo induced by a glare source and forward scatter or visual acuity (VA) in healthy eyes. Method -Measurements were made in the right eyes of 51 healthy individuals of mean age 29.3±7.5 years. Halo radius was measured using the Vision Monitor and low luminance (1 cd/m2) optotypes presented at a distance of 2.5 m. The visual angle subtended by the radius of the halo was calculated in minutes of arc (arc min). Forward scatter or, straylight, was measured using the compensation comparison technique. Best-corrected distance VA was measured using high contrast (HC) (96%) and low contrast (LC) (10%) Bailey-Lovie logMAR letter charts under photopic (85 cd/m2) and mesopic (0.15 cd/m2) luminance conditions. Results -Mean halo radius was 202±43 arc min (3.4±0.7°) and mean retinal straylight was 0.95±0.12 log units. Mean photopic distance HC-VA and LC-VA were −0.02±0.06 and 0.12±0.09 logMAR, respectively. Mean mesopic distance HC-VA and LC-VA were 0.35±0.11 and 0.74±0.11 logMAR, respectively. Forward stepwise regression analysis revealed that halo radius was significantly correlated with straylight (r=0.45) and mesopic LC-VA (r=0.48), but not with photopic HC-VA and/or LC-VA and mesopic HC-VA. Conclusions -In healthy eyes, the larger the halo size induced by a given glare source, the greater the forwardscatter (straylight) and worse the mesopic LC-VA. Halo size seems to be independent of photopic HC-VA or LC-VA and mesopic HC-VA.Item Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration(Investigative Ophthalmology and Visual Science, 2012) Puell Marín, María Cinta; Barrio De Santos, Ana Rosa; Palomo Álvarez, Catalina; Gómez Sanz, Fernando J.; Clement Corral, Amaya; Pérez Carrasco, María JesúsPurpose.: To determine photopic and mesopic distance high-contrast visual acuity (HC-VA) and low-contrast visual acuity (LC-VA) in eyes with early age-related macular degeneration (AMD). Methods.: Measurements were made in 22 subjects with early AMD and 28 healthy control subjects. Inclusion criteria included a photopic HC-VA of 20/25 or better. Distance VA was measured using HC (96%) and LC (10%) Bailey-Lovie logMAR letter charts under photopic (85 cd/m2) and mesopic (0.1–0.2 cd/m2) luminance conditions. Results.: Mean mesopic distance HC-VA and LC-VA were significantly worse (0.1 logMAR and 0.28 logMAR, respectively) in the early AMD group than in the control group. Under mesopic conditions, the mean difference between LC-VA and HC-VA was significantly greater in the early AMD (0.45 logMAR) than the control group (0.27 logMAR). Mean differences between mesopic versus photopic HC-VA and mesopic versus photopic LC-VA were significantly greater in the early AMD than the control group (0.13 and 0.32 logMAR of difference between the means, respectively). Sensitivity and specificity were significantly greater for mesopic LC-VA than for mesopic HC-VA (Receiver Operating Characteristics, area under the curve [AUC], 0.94 ± 0.030 and 0.76 ± 0.067, respectively). AUC values for photopic HC-VA and LC-VA were below 0.70. Conclusions.: Visual acuity testing under low luminance conditions emerged as an optimal quantitative measure of retinal function in early AMD.Item Macular Thickness and Mesopic Visual Acuity in Healthy Older Subjects(Current Eye Research, 2018) Puell Marín, María Cinta; Pérez Carrasco, María Jesús; Palomo Álvarez, CatalinaPurpose/Aim: Impaired mesopic visual acuity (VA) is a risk factor for incident early age-related macular degeneration (AMD) This study examines relationships between macular thickness measurements and photopic or mesopic VA in healthy eyes. Materials and Methods: In 38 young and 39 older healthy individuals, total, inner, and outer retinal layer (IRL and ORL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT). Measurements were made across three subfields centered at the fovea: central foveal, pericentral, and peripheral. Best-corrected distance high-contrast (HC) and low-contrast (LC) VA were measured using Bailey-Lovie logMAR letter charts under photopic and mesopic luminance conditions. In addition, the low luminance deficit in VA (LLD, difference between photopic and mesopic VA) was calculated. Relationships were examined through Spearman correlation in each age group and through multiple linear regressions across all eyes. Results: No significant correlations were detected between photopic VA (HC-VA and LC-VA) and macular thickness measurements in each age group. In mesopic conditions, age and pupil size were independent predictors of HC-VA (p = 0.001) and age and pericentral ORL thickness predictors of LC-VA (p = 0.001). Central foveal thickness emerged as the unique independent predictor of LLD (HC-VA, p = 0.013 and LC-VA, p = 0.005). Only in the older age group, was central foveal thicknesses correlated with LLD (HC-VA, r = + 0.45; p = 0.004 and LC-VA, r = + 0.33, p = 0.038). Conclusions: Greater macular thicknesses were related to worse mesopic VA and low luminance deficit in healthy subjects.