Person: Pérez Carrasco, María Jesús
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First Name
María Jesús
Last Name
Pérez Carrasco
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Óptica y Optometría
Department
Optometría y Visión
Area
Optica
Identifiers
9 results
Search Results
Now showing 1 - 9 of 9
Item Macular Inner Retinal Layer Thickness in Relation to Photopic and Mesopic Contrast Sensitivity in Healthy Young and Older Subjects(Investigative Ophthalmology & Vision Science, 2018) Puell Marín, María Cinta; Palomo Álvarez, Catalina; Pérez Carrasco, María JesúsPurpose: To examine relationships between the thicknesses of ganglion cell (GC)-related macular layers and central photopic or mesopic contrast sensitivity (CS) in healthy eyes. Methods: Measurements were made in 38 young and 38 older healthy individuals. Total, inner, and outer retinal layer (IRL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT) across three subfields, or rings, centered at the fovea: central foveal, pericentral, and peripheral. Ganglion cell complex and circumpapillary retinal nerve fiber layer thicknesses were also measured. Low-spatial-frequency CS for gratings presented at the central 10° visual field were measured through computerized psychophysical tests under photopic and mesopic conditions. Relationships were examined by uni- and multivariate regression analysis. Results: Peripheral IRL thickness emerged as the only independent predictor of photopic CS (P = 0.001) in the young group and of photopic (P = 0.026) and mesopic CS (P = 0.001) in the older group. The slopes of regression lines used to predict CS from peripheral IRL thickness were significantly different for pair-wise comparisons of both photopic CS and age group (P = 0.0001) and mesopic CS (P = 0.0001) and age group. These models explained 37% of the variability in photopic CS and 36% of the variability in mesopic CS. Conclusions: Macular IRL thinning likely due to GC loss was related to reduced photopic and mesopic CS in older healthy eyes. In contrast, in the young eyes, a thicker macular IRL, possibly indicating transient gliosis, was associated with reduced CS.- Project number: 163
Item Atlas electrónico de registros retinográficos y tomográficos: cribado, derivación, diagnóstico diferencial y seguimiento de afecciones retinianas Parte IV: Retinopatía del Prematuro(2018) Sánchez Ramos, Celia; Pérez Carrasco, María Jesús; Bonnin Arias, Cristina Natalia; Panetsos Petrova, Fivos; Blanco Torcal, Barbara Prisca; Navarro Blanco, Carolina; Blázquez Sánchez, VanesaEl objetivo de este proyecto es continuar con el Atlas retinográfico iniciado en las convocatorias anteriores con imágenes obtenidas con los principales y novedosos instrumentos utilizados en la actualidad para el diagnóstico de patologías retinianas. El Atlas presenta, además de las imágenes, una detallada descripción de los criterios cribado. Esta cuarta parte se centra en el diagnóstico por imagen de la retinopatía del prematuro, que se define como una vitreorretinopatía fibro y vasoproliferativa periférica que acontece en los recién nacidos inmaduros, generalmente sometidos a oxigenoterapia. El Atlas está constituido por una extensa relación de retinografías (fotografías del fondo de ojo–retina) y tomografías de coherencia óptica (imágenes de cortes histológicos de la retina en vivo), exponiendo casos reales de patologías comunes y poco comunes. Constituye una herramienta con triple función: por un lado, será un elemento didáctico para el aprendizaje de patologías retinianas y el método de diagnóstico por imagen; en segundo lugar, puede utilizarse para realizar autoevaluaciones y, en tercer lugar, constituye una completa base de datos de casos clínicos. En definitiva, se trata de una herramienta muy económica y de gran utilidad para un amplio grupo de profesionales sanitarios expertos y especialistas en sistema visual. - Project number: 231
Item Atlas electrónico de registros retinográficos y tomográficos: cribado, derivación, diagnóstico diferencial y seguimiento de afecciones retinianas. Parte V: Distrofias retinianas(2019) Sánchez Ramos, Celia; Pérez Carrasco, María Jesús; Bonnin Arias, Cristina Natalia; Blázquez Sánchez, Vanesa; Jiménez De Las Heras, José Antonio; Jimeno Aranda, Ricardo; Cuiña Sardiña, Ricardo; Navarro Blanco, Carolina; Blanco Torcal, Bárbara PriscaEl objetivo de este proyecto es continuar con el Atlas retinográfico iniciado en las convocatorias anteriores con imágenes obtenidas con los principales y novedosos instrumentos utilizados en la actualidad para el diagnóstico de patologías retinianas. El Atlas presenta, además de las imágenes, una detallada descripción de los criterios cribado. Esta quinta parte se centra en el diagnóstico por imagen de distrofias retinianas, que son un grupo heterogéneo de enfermedades hereditarias de la retina, por lo general bilaterales y progresivas, que conducen a la pérdida de visión funcional hasta la ceguera. El Atlas está constituido por una extensa relación de retinografías (fotografías del fondo de ojo–retina) y tomografías de coherencia óptica (imágenes de cortes histológicos de la retina en vivo), exponiendo casos reales de patologías comunes y poco comunes. Constituye una herramienta con triple función: por un lado, será un elemento didáctico para el aprendizaje de patologías retinianas y el método de diagnóstico por imagen; en segundo lugar, puede utilizarse para realizar autoevaluaciones y, en tercer lugar, constituye una completa base de datos de casos clínicos. En definitiva, se trata de una herramienta muy económica y de gran utilidad para un amplio grupo de profesionales sanitarios expertos y especialistas en sistema visual. Item Retinal protection from LED-backlit screen lights by short wavelength absorption filters(Cells, 2021) Sánchez Ramos, Celia; Bonnin Arias, Cristina Natalia; Blázquez Sánchez, Vanesa; Aguirre Vilacoro, Victoria; Cobo Díaz, Teresa; García Suárez, Olivia; Pérez Carrasco, María Jesús; Álvarez Peregrina, Cristina; Vega Álvarez, José AntonioBackground: Ocular exposure to intense light or long-time exposure to low-intensity short-wavelength lights may cause eye injury. Excessive levels of blue light induce photochemical damage to the retinal pigment and degeneration of photoreceptors of the outer segments. Currently, people spend a lot of time watching LED screens that emit high proportions of blue light. This study aims to assess the effects of light emitted by LED tablet screens on pigmented rat retinas with and without optical filters. Methods: Commercially available tablets were used for exposure experiments on three groups of rats. One was exposed to tablet screens, the other was exposed to the tablet screens with a selective filter and the other was a control group. Structure, gene expression (including life/death, extracellular matrix degradation, growth factors, and oxidative stress related genes), and immunohistochemistry in the retina were compared among groups. Results: There was a reduction of the thickness of the external nuclear layer and changes in the genes involved in cell survival and death, extracellular matrix turnover, growth factors, inflammation, and oxidative stress, leading decrease in cell density and retinal damage in the first group. Modulation of gene changes was observed when the LED light of screens was modified with an optical filter. Conclusions: The use of short-wavelength selective filters on the screens contribute to reduce LED light-induced damage in the rat retina.Item Association between central retinal thickness and low luminance visual acuity in early age-related macular degeneration(European Journal of Ophthalmology, 2020) Puell Marín, María Cinta; Hurtado Ceña, Francisco Javier; Pérez Carrasco, María Jesús; Contreras Martín, InésPurpose/Aim: To examine whether central retinal thickness (CRT) is related to mesopic visual acuity (VA) and low luminance deficit (LLD, difference between photopic and mesopic VA) in eyes with early and intermediate age-related macular degeneration (AMD). Materials and Methods: In a cross-sectional study, 50 pseudophakic subjects older than 63 years were divided into three groups (no AMD, early AMD and intermediate AMD). Spectral domain optical coherence tomography (SD-OCT) was used to measure CRT in the 1 mm-central-area. Best-corrected distance VA was measured under photopic or mesopic luminance conditions and LLD calculated. Subjects were stratified by VA impairment to compare CRTs across these groups. Relationships were examined by stepwise multiple linear regression. Results: No significant differences in mean CRT, photopic and mesopic VA or LLD were detected between the groups no AMD, early AMD and intermediate AMD. However, mean CRTs were 20 microns and 18 microns thicker in the eyes with impaired mesopic VA (> 0.3 logMAR) and impaired LLD (⩾ 0.3 logMAR) compared to the eyes with non-impaired VA or LLD respectively (both p < 0.01). CRT and mesopic pupil size were independent predictors of mesopic VA (p = 0.001). CRT emerged as the only independent predictor of LLD (p = 0.004). Conclusions: Increased CRT was linked to worse retinal function when measured under mesopic conditions in eyes without AMD and eyes with early to intermediate AMD. SD-OCT imaging combined with VA measurements under low luminance conditions could be a useful tool to detect early AMD.Item Relationship Between Flicker Modulation Sensitivity and Retinal Ganglion Cell Related Layer Thicknesses(Translational vision science & technology, 2021) Pérez Carrasco, María Jesús; Carballo Álvarez, Jesús; Barbur, John L.; Puell Marín, María CintaPurpose: Early detection of structural changes in retinal ganglion cells (RGCs) and corresponding changes in visual function is important in early degenerative diseases of the retina, but the sensitivity of both measurements is limited by the inherent variability in healthy subjects. This study investigates the relationships between RGC-related layer thicknesses and foveal and parafoveal flicker modulation sensitivity (FMS) across photopic and mesopic light levels in healthy subjects. Methods: Photopic and mesopic FMS was measured in 56 young adults, at the point of fixation and at an eccentricity of 5 degrees, in each of the four quadrants. Spectraldomain optical coherence tomography (SD-OCT) was used to measure retinal thicknesses. Relationships between foveal and parafoveal FMS and the retinal thickness in the corresponding region were examined after adjusting for confounding variables. Results: Total macular and inner retinal layer (IRL) thicknesses in the parafoveal ring were significant predictors of photopic (P = 0.034) and mesopic (P = 0.034) parafoveal FMS, respectively. The superior peripapillary retinal nerve fiber layer (pRNFL) thickness was a contributing factor to the inferior parafoveal FMS (photopic: P = 0.006 and mesopic: P = 0.021) and the inferior pRNFL thickness was also a contributing factor to the superior parafoveal FMS (photopic: P < 0.001 and mesopic: P = 0.015). Conclusions: The pRNFL thicknesses predict parafoveal FMS for both mesopic and photopic conditions in healthy eyes. Translational Relevance: Themeasurement of rapid flicker sensitivity in the parafoveal retina together with the pRNFL thickness profiles measured before the onset of disease, may provide a more sensitive biomarker for detecting loss of sensitivity caused by the earliest neurodegenerative changes in the eyes.Item Macular Thickness and Mesopic Visual Acuity in Healthy Older Subjects(Current Eye Research, 2018) Puell Marín, María Cinta; Pérez Carrasco, María Jesús; Palomo Álvarez, CatalinaPurpose/Aim: Impaired mesopic visual acuity (VA) is a risk factor for incident early age-related macular degeneration (AMD) This study examines relationships between macular thickness measurements and photopic or mesopic VA in healthy eyes. Materials and Methods: In 38 young and 39 older healthy individuals, total, inner, and outer retinal layer (IRL and ORL) thicknesses were measured in the macula region through spectral-domain optical coherence tomography (SD-OCT). Measurements were made across three subfields centered at the fovea: central foveal, pericentral, and peripheral. Best-corrected distance high-contrast (HC) and low-contrast (LC) VA were measured using Bailey-Lovie logMAR letter charts under photopic and mesopic luminance conditions. In addition, the low luminance deficit in VA (LLD, difference between photopic and mesopic VA) was calculated. Relationships were examined through Spearman correlation in each age group and through multiple linear regressions across all eyes. Results: No significant correlations were detected between photopic VA (HC-VA and LC-VA) and macular thickness measurements in each age group. In mesopic conditions, age and pupil size were independent predictors of HC-VA (p = 0.001) and age and pericentral ORL thickness predictors of LC-VA (p = 0.001). Central foveal thickness emerged as the unique independent predictor of LLD (HC-VA, p = 0.013 and LC-VA, p = 0.005). Only in the older age group, was central foveal thicknesses correlated with LLD (HC-VA, r = + 0.45; p = 0.004 and LC-VA, r = + 0.33, p = 0.038). Conclusions: Greater macular thicknesses were related to worse mesopic VA and low luminance deficit in healthy subjects.Item Symptomatology associated by use of computers in university students.(2019) Gutiérrez Jorrín, Sara; Rodríguez Alonso, Xabier; Bonnin Arias, Cristina Natalia; Pérez Carrasco, María Jesús; Panetsos Petrova, Fivos; Sánchez Ramos, CeliaThe use of computers and electronic devices (tablets and smartphones) is essential in many aspects of current academic, professional and social life, as the number of people who uses this devices has increased exponentially in recent years. In fact, a recent report suggests that adults can spend, on average, approximately 8.5 hours per day watching electronic screens. Studies suggest that between 64 and 90% of device users experience visual symptoms. These symptoms include eyestrain, headaches, eye discomfort, dry eye, diplopia, and blurred vision, either in far or near visionItem IT workers and Computer Vision Syndrome.(2019) Rodríguez Alonso, Xabier; Gutiérrez Jorrín, Sara.; Bonnin Arias, Cristina Natalia; Pérez Carrasco, María Jesús; Panetsos Petrova, Fivos; Sánchez Ramos, CeliaIn today's world, the visualization of digital screens has become a large part of daily life at home, at work, during free time and in movement. The use of data visualization terminals (desktop, laptops, tablets and smartphones) has become a universal activity. In fact, a recent report suggests that adults can pass, in average, approximately 8.5 hours per day watching digital screens. Studies suggest that between 64 and 90% of device users experience visual symptoms. These symptoms include visual fatigue, headache, eye discomfort, dry eye, diplopia and blurred vision, either in far or near vision. In this study, the risks of the use of LED screens are evaluated in working age adult population who spend large amounts of time working in front of LED screens.