Person:
Peláez García, María Teresa

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First Name
María Teresa
Last Name
Peláez García
URI
https://hdl.handle.net/20.500.14352/83717
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Area
Microbiología
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2011 - 20152
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Start date: 2010 ×

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Now showing 1 - 2 of 2
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    Exercise during pregnancy improves maternal health perception: a randomized controlled trial
    (American Journal of Obstetrics and Gynecology, 2011) Barakat, Ruben; Peláez García, María Teresa; Montejo, Rocio; Luaces Méndez, María; Zakynthinaki, Maria
    Objective We have studied the effect of moderate physical activity that is performed by healthy women during their entire pregnancy on their perception of health status. Study Design Eighty sedentary women were assigned randomly to either an exercise group (n = 40) or a control group (n = 40). Maternal perception of health status and several pregnancy outcomes were recorded. Results Significant differences (P = .03) were found between study groups in the percentage of women who perceived their health status as “very good”; the values that corresponded to the exercise group (n = 18; 54.5%) were better than those of the control group (n = 9; 27.3%). In addition, the women of the exercise group gained less weight (11,885 ± 3146 g) than those of the control group (13,903 ± 2113; P = .03). Conclusion A moderate physical activity program that is performed over the first, second, and third trimester of pregnancy improves the maternal perception of health status.
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    Effect of Melatonin and Analogues on Corneal Wound Healing: Involvement of Mt2 Melatonin Receptor
    (Current Eye Research, 2015) Crooke Álvarez, Almudena; Guzmán Aránguez, Ana Isabel; Mediero Muñoz, Aránzazu; Alarma Estrany, Pilar; Carracedo Rodríguez, Juan Gonzalo; Peláez García, María Teresa; Peral Cerda, María Asunción; Pintor Just, Jesús Jerónimo
    Purpose: We have investigated the effect of melatonin and its analogues on rabbit corneal epithelial wound healing. Methods: New Zealand rabbits were anaesthetised and wounds were made by placing Whatman paper discs soaked in n-heptanol on the cornea. Melatonin and analogues (all 10 nmol) were instilled. Wound diameter was measured every 2 hours by means of fluorescein application with a Topcon SL-8Z slit lamp. Melatonin antagonists (all 10 nmol) were applied 2 hours before the application of the n-heptanol-soaked disc and then every 6 hours together with melatonin. To confirm the presence of MT2 receptors in corneal epithelial cells immunohistochemistry, Western blot and RT-PCR assays in native tissue and in rabbit corneal epithelial cells were performed. The tear components were extracted then processed by HPLC to quantify melatonin in tears. Results: Migration assays revealed that melatonin and particularly the treatment with the MT2 agonist IIK7, accelerated the rate of healing (p < 0.001). The application of the non-selective melatonin receptor antagonist luzindole and the MT2 antagonist DH97 (but not prazosin), prevented the effect of melatonin on wound healing (both p < 0.001). Immunohistochemistry, Western blot and RT-PCR assays showed the presence of MT2 melatonin receptor in corneal epithelial cells. In addition, we have identified melatonin in tears and determined its daily variations. Conclusions: These data suggest that MT2 receptors are implicated in the effect of melatonin on corneal wound healing regulating migration rate. This suggests the potential use of melatonin and its analogues to enhance epithelial wound healing in ocular surface disease.