Person:
Mateos-Aparicio Morales, Gregoria

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First Name
Gregoria
Last Name
Mateos-Aparicio Morales
URI
https://hdl.handle.net/20.500.14352/81473
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Económicas y Empresariales
Department
Estadística e Investigación Operativa
Area
Estadística e Investigación Operativa
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Start date: 2010 × Subject: 612.017 ×

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    Evaluation of Polysaccharide Typhim Vi Antibody Response as a predictor of Humoral Immunodeficiency in Haematological Malignancies
    (Clinical Immunology, 2020) Ochoa-Grullón, J. et al.; S. Sánchez-Ramón; Benavente Cuesta, Celina; Pérez López, César; Peña Cortijo, Ascensión; Mateos-Aparicio Morales, Gregoria; Williams, J.L. ; Fernández Arquero, Miguel; Recio Hoyas, María José
    An increasing healthcare challenge in the management of haematological malignancy (HM) is secondary immunodeficiency. From January 2019, the EMA included the evaluation of specific antibody (Ab) responses to better select patients for immunoglobulin replacement therapy (IgRT). We evaluated Ab responses to pneumococcal and Salmonella typhi pure polysaccharide immunization in a cohort of 42 HM patients and 24 healthy-controls. Pre-post specific Ab concentrations were measured by ELISA at 4 weeks. Globally, significantly lower Typhim Vi (TV) seroprevalence (9%) compared to 23-valent pneumococcal polysaccharide vaccine (PPV) (76%) (p <0.001) was observed. TV non responders (88%) were higher than PPV non responders (62%) (p <0.0001) and correlated better to infectious history. By ROC analysis, pre-post 5-fold TV increase was the best cut-off to discriminate HM with recurrent infections and controls (sensitivity 91%, specificity 100%). Despite the small sample cohort, our results suggest that specific anti-S typhi Ab response is a useful complementary assay in the diagnosis and management decision of SID to HM.