Person:
Guzmán Solís, Eduardo

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First Name
Eduardo
Last Name
Guzmán Solís
URI
https://hdl.handle.net/20.500.14352/76095
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Física
Area
Química Física
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Author: Maestro, Armando × Subject: 544 ×

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Now showing 1 - 3 of 3
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    Fluid interfaces as models for the study of lipid-based films with biophysical relevance
    (Coatings, 2023) Argudo, Pablo G.; Maestro, Armando; Guzmán Solís, Eduardo
    This comprehensive review aims to provide a deep insight into the fascinating field of biophysics in living organisms through the study of model fluid interfaces that mimic specific lipid-based structures with biophysical relevance. By delving into the study of these physiological fluid interfaces, we can unravel crucial aspects of their behavior, lateral organization, and functions. Through specific examples, we will uncover the intricate dynamics at play and shed light on potential pathogenic conditions that may result from alterations in these interfaces. A deeper understanding of these aspects can lead to the emergence of novel technologies and medical advances, potentially leading to the development of innovative treatments and diagnostic tools.
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    Unravelling the orientation of the inositol-biphosphate ring and its dependence on phosphatidylinositol 4,5-bisphosphate cluster formation in model membranes
    (Journal Colloid and Interface Science, 2023) Santamaria, Andreas; Javier Carrascosa-Tejedor; Guzmán Solís, Eduardo; Zaccai, Nathan R.; Maestro, Armando
    Hypothesis Inositol phospholipids are well known to form clusters in the cytoplasmic leaflet of the plasma membrane that are responsible for the interaction and recruitment of proteins involved in key biological processes like endocytosis, ion channel activation and secondary messenger production. Although their phosphorylated inositol ring headgroup plays an important role in protein binding, its orientation with respect to the plane of the membrane and its lateral packing density has not been previously described experimentally. Experiments Here, we study phosphatidylinositol 4,5-bisphosphate (PIP2) planar model membranes in the form of Langmuir monolayers by surface pressure-area isotherms, Brewster angle microscopy and neutron reflectometry to elucidate the relation between lateral (in-plane) and perpendicular (out-of-plane) molecular organization of PIP2. Findings Different surface areas were explored through monolayer compression, allowing us to correlate the formation of transient PIP2 clusters with the change in orientation of the inositol-biphosphate headgroup, which was experimentally determined by neutron reflectometry.
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    Probing the effect of the capping polyelectrolyte on the internal structure of Layer-by-Layer decorated nanoliposomes
    (Journal Colloid and Interface Science, 2023) Mateos-Maroto, Ana; Rubio, José ; Prévost, Sylvain; Maestro, Armando; González Rubio, Ramón; Ortega Gómez, Francisco; Guzmán Solís, Eduardo
    Hypothesis The internal organization of polyelectrolyte layers deposited on colloidal templates plays a very important role for the potential applications of these systems as capsules for drug delivery purposes. Experiments The mutual arrangement of oppositely charged polyelectrolyte layers upon their deposition on positively charged liposomes has been studied by combining up three different scattering techniques and Electronic Spin Resonance, which has provided information about the inter-layer interactions and their effect on the final structure of the capsules. Findings The sequential deposition of oppositely charged polyelectrolytes on the external leaflet of positively charged liposomes allows modulating the organization of the obtained supramolecular structures, impacting the packing and rigidity of the obtained capsules due to the change of the ionic cross-linking of the multi-layered film as a result of the specific charge of the last deposited layer. The possibility to modulate the properties of the LbL capsules by tuning the characteristics of the last deposited layers offers a very interesting route for the design of materials for encapsulation purposes with their properties controlled almost at will by changing the number of deposited layers and their chemistry.