Person:
Olmeda García, Ángeles Sonia

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First Name
Ángeles Sonia
Last Name
Olmeda García
URI
https://hdl.handle.net/20.500.14352/80371
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Sanidad Animal
Area
Sanidad Animal
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Start date: 2020 × Subject: 576.8 ×

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    Alpha-Gal, epitope responsible for allergy to red meat, in the Mediterranean tick Hyalomma lusitanicum
    (Medical and Veterinary Entomology, 2024) Valcárcel Olmeda, Ángela; Briones Montero, Andrea; Rodero Martínez, Marta; González Fernández, Juan; Olmeda García, Ángeles Sonia; Valcárcel, Félix; Cuéllar Del Hoyo, María Del Carmen
    Alpha-Gal/α-Gal is an oligosaccharide produced by non-primate mammals. Humans have developed an immune response mediated by anti-α-Gal antibodies that can trigger an allergic reaction and cause anaphylaxis. In recent years, cases of patients with delayed allergic reaction to mammalian meat have been reported worldwide. In Spain, these cases have been related to the species Ixodes ricinus L. (Ixodida: Ixodidae), whose distribution is located in the north of the country. In this work, the presence of α-Gal in water-soluble extracts from samples of salivary glands and digestive tracts of Hyalomma lusitanicum Koch (Ixodida: Ixodidae) both engorged and collected from vegetation were studied. The presence of that epitope was confirmed by the presence of reactive proteins of >250 kDa in both samples. The highest concentrations of α-Gal were detected in salivary glands. Neither sex nor diet influenced the concentration of α-Gal, which seems to indicate its endogenous production and its possible inoculation to the host during tick feeding.