Person:
Manzano Figueroa, Sara

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First Name
Sara
Last Name
Manzano Figueroa
URI
https://hdl.handle.net/20.500.14352/86948
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Bioquímica y Biología Molecular
Area
Bioquímica y Biología Molecular
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Author: Manzano Figueroa, Sara ×

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    Papel de C3G en la diseminación, tumorigénesis y señalización celular del glioblastoma
    (2021) Manzano Figueroa, Sara; Porras Gallo, María Almudena; Gutiérrez-Uzquiza, Álvaro
    GBMs (glioblastomas), or grade IV astrocytomas/gliomas, are the most frequent and aggressive brain tumours, whose diagnosis and treatment is still inefficient. RTKs (receptor tyrosine-kinases), mainly EGFR, and their downstream pathways are altered in almost 90% GBMs. RTKs, are relevant for the regulation of GBM tumourigenesis and dissemination and for GSCs (GBM stem cells), a GBM subpopulation that display stem-like and GBM-initiating properties. Dissemination is also linked to GBM aggressiveness. EMT (epithelial-mesenchymal transition)-like processes would facilitate the acquisition of a more mesenchymal and invasive phenotype. Both, stemness and disseminative capacity have been associated to GBM recurrence and therapy resistance...