Person:
Pérez Sancho, Marta

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First Name
Marta
Last Name
Pérez Sancho
URI
https://hdl.handle.net/20.500.14352/80416
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Sanidad Animal
Area
Sanidad Animal
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Author: Domínguez Rodríguez, Lucas José × Subject: 579.62 ×

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    New insights into the pathogenesis and transmission of Brucella pinnipedialis: systemic infection in two bottlenose dolphins (Tursiops truncatus)
    (Microbiology Spectrum, 2023) Vargas Castro, Ignacio; Crespo Picazo, José Luis; Fayos, Manena; Jiménez Martínez, María De Los Ángeles; Torre Fuentes, Laura; Álvarez Sánchez, Julio; Moura, André E.; Hernández, Marta; Buendía Andrés, Aranzazu; Barroso Arévalo, Sandra; García-Seco Romero, María Teresa; Pérez Sancho, Marta; De Miguel, María Jesús; Andrés Barranco, Sara; Marco Cabedo, Vicente; Peñín Villahoz, Gaizka; Muñoz, Pilar María; Domínguez Rodríguez, Lucas José; García Párraga, Daniel; Sánchez-Vizcaíno Rodríguez, José Manuel
    The emergence of Brucella infections in marine mammals is a growing concern. The present study reports two cases of systemic Brucella pinnipedialis infection detected in bottlenose dolphins (Tursiops truncatus) pair stranded together in the Cantabrian coast of Spain. Both animals showed systemic lesions associated with the Brucella infection, more severe in the younger dolphin, considered the likely offspring of the other individual. Real-time PCR, bacterial culture, and whole-genome sequencing were used to detect and characterize the Brucella strains involved in both dolphins. The phylogenetic analysis performed on the Brucella genomes retrieved revealed that the species involved was B. pinnipedialis (ST25). Both animals resulted seropositive in a commercial multispecies blocking ELISA but tested negative in the standard Rose Bengal test. To the best of our knowledge, this is the first report of a systemic infection resulting in various lesions associated with Brucella pinnipedialis (ST25) in two bottlenose dolphins. It is also the initial isolation of Brucella in the milk of a non-pregnant or non-aborting female cetacean likely stranded with its offspring. These findings provide new insights into the epidemiology and clinical impact of B. pinnipedialis infection in cetaceans and underscore the importance of continued diagnostic surveillance to gain better understanding of brucellosis effects and transmission in marine mammal populations.