Person: Cazorla Luna, Raúl
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First Name
Raúl
Last Name
Cazorla Luna
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Farmacia Galénica y Tecnología Alimentaria
Area
Farmacia y Tecnología Farmaceútica
Identifiers
5 results
Search Results
Now showing 1 - 5 of 5
Item Formulaciones sólidas mucoadhesivas vaginales basadas en polímeros naturales para liberación sostenida de microbicidas destinadas a la prevención de la transmisón sexual del VIH(2021) Cazorla Luna, Raúl; Veiga Ochoa, María Dolores; Ruiz Caro, RobertoEn ausencia de una vacuna eficaz frente al virus de la inmunodeficiencia humana (VIH), el Programa Conjunto de las Naciones Unidas sobre el VIH/SIDA (ONUSIDA) recomienda el desarrollo productos estables, seguros, efectivos y aceptables que puedan reducir con éxito la transmisión sexual de este virus. La profilaxis preexposición mediante formulaciones de administración vaginal puede ser útil para este objetivo, ya que aporta a las mujeres una opción de autoprotección sin necesidad del consentimiento de la pareja sexual. Sin embargo, ensayos clínicos con microbicidas de administración vaginal han fallado en su propósito debido a una baja adherencia al tratamiento al ser necesaria una administración diaria. En el presente trabajo de tesis se propone el desarrollo y la evaluación de formulaciones vaginales basadas en polímeros naturales para la liberación sostenida de fármacos antirretrovirales...Item Mucoadhesive Vaginal Discs based on Cyclodextrin and Surfactants for the Controlled Release of Antiretroviral Drugs to Prevent the Sexual Transmission of HIV(Pharmaceutics, 2020) Notario Pérez, Fernando; Martín Illana, Araceli; Cazorla Luna, Raúl; Ruiz Caro, Roberto; Tamayo, Aitana; Rubio, Juan; Veiga Ochoa, María DoloresThe strategies for developing vaginal microbicides to protect women against human immunodeficiency virus (HIV) sexual transmission are constantly changing. Although the initial dosage forms required daily administration to offer effective protection, the trend then moved towards sustained-release dosage forms that require less frequency of administration in order to improve women’s compliance with the treatment. Nevertheless, another possible strategy is to design on-demand products that can be used in a coitally-dependent manner and only need to be administered immediately before intercourse to offer protection. Vaginal discs based on freeze-dried hydroxypropylmethyl cellulose gels have been developed for this purpose, containing two surfactants, i.e., sodium dodecyl sulphate and polysorbate 60, alone or in combination with 2-hydroxypropyl-β cyclodextrin, to achieve a formulation capable of incorporating both hydrophilic and lipophilic drugs. Several studies have been carried out to evaluate how the inclusion of these substances modifies the structure of gels (viscosity and consistency studies) and the porosimetry of the freeze-dried discs (scanning electron microscopy micrographs, mechanical properties, swelling behaviour). The drug release and mucoadhesive properties of the discs have also been evaluated with a view to their clinical application. The systems combining sodium dodecyl sulphate and 2-hydroxypropyl-β-cyclodextrin were found to be adequate for the vaginal administration of both Tenofovir and Dapivirine and also offer excellent mucoadhesion to vaginal tissue; these discs could therefore be an interesting option for a coitally-dependent administration to protect women against HIV transmission.- Project number: 372
Item Resiliencia y adaptabilidad en Farmacia: Aprovechamiento de la experiencia de enseñanza-aprendizaje en tiempos de pandemia por CoVid19 aplicando B-Learning y learning analytics(2022) Notario Pérez, Fernando; Ruiz Caro, Roberto; Veiga Ochoa, María Dolores; Molina Martínez, Irene Teresa; Herrero Vanrell, María del Rocío; Bravo Osuna, Irene; Vicario de la Torre, Marta; Martin Erdocia, Izaskun; Cazorla Luna, Raúl; García Herranz, David; López Cano, José Javier; Martín Illana, Araceli; Gil Alegre, María Esther; Andrés Guerrero, Vanessa; Aragon Navas, Alba Item Bigels as drug delivery systems: From their components to their applications(Drug Discovery Today, 2021) Martín Illana, Araceli; Notario Pérez, Fernando; Cazorla Luna, Raúl; Ruiz Caro, Roberto; Bonferoni, Maria C.; Tamayo, Aitana; Veiga Ochoa, María DoloresBigels are systems that usually result from mixing a hydrogel and an organogel: the aqueous phase is commonly formed by a hydrophilic biopolymer, whereas the organic phase comprises a gelled vegetable oil because of the presence of an organogelator. The proportion of the corresponding gelling agent in each phase, the organogel/hydrogel ratio, and the mixing temperature and speed all need to be taken into consideration for bigel manufacturing. Bigels, which are particularly useful drug delivery systems, have already been formulated for transdermal, buccal, and vaginal routes. Mechanical assessments and microscopy are the most reported characterization techniques. As we review here, their composition and unique structure confer promising drug delivery attributes, such as mucoadhesion, the ability to control drug release, and the possibility of including both hydrophilic and lipophilic drugs in the same system.Item Vaginal Polyelectrolyte Layer-by-Layer Films Based on Chitosan Derivatives and Eudragit® S100 for pH Responsive Release of Tenofovir(Marine Drugs, 2020) Cazorla Luna, Raúl; Martín Illana, Araceli; Notario Pérez, Fernando; Bedoya del Olmo, Luis Miguel; Tamayo, Aitana; Ruiz-Caro, Roberto; Rubio, Juan; Veiga Ochoa, María DoloresWomen are still at high risk of contracting the human immunodeficiency virus (HIV) virus due to the lack of protection methods under their control, especially in sub-Saharan countries. Polyelectrolyte multilayer smart vaginal films based on chitosan derivatives (chitosan lactate, chitosan tartate, and chitosan citrate) and Eudragit® S100 were developed for the pH-sensitive release of Tenofovir. Films were characterized through texture analysis and scanning electron microscopy (SEM). Swelling and drug release studies were carried out in simulated vaginal fluid and a mixture of simulated vaginal and seminal fluids. Ex vivo mucoadhesion was evaluated in bovine vaginal mucosa. SEM micrographs revealed the formation of multilayer films. According to texture analysis, chitosan citrate was the most flexible compared to chitosan tartrate and lactate. The swelling studies showed a moderate water uptake (<300% in all cases), leading to the sustained release of Tenofovir in simulated vaginal fluid (up to 120 h), which was accelerated in the simulated fluid mixture (4–6 h). The films had high mucoadhesion in bovine vaginal mucosa. The multilayer films formed by a mixture of chitosan citrate and Eudragit® S100 proved to be the most promising, with zero toxicity, excellent mechanical properties, moderate swelling (<100%), high mucoadhesion capacity, and Tenofovir release of 120 h and 4 h in vaginal fluid and the simulated fluid mixture respectively.