Person:
Moreno Guzmán, María

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First Name
María
Last Name
Moreno Guzmán
URI
https://hdl.handle.net/20.500.14352/77485
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Química en Ciencias Farmacéuticas
Area
Química Analítica
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Author: García-Carmona, Laura × Subject: 576.3 ×

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    Class enzyme-based motors for “on the fly” enantiomer analysis of amino acids
    (Biosensors and Bioelectronics, 2017) García-Carmona, Laura; Moreno Guzmán, María; González, María Cristina; Escarpa, Alberto
    Here, two class-enzyme motors are properly designed allowing the rapid dispersion of the class-enzyme D-amino acid oxidase (DAO) and L-amino acid oxidase (LAO) for selective “on the fly” biodetection of D and L-amino acids (AAs), respectively. The efficient movement together with the continuous release of fresh class-enzyme leads to a greatly accelerated enzymatic reaction processes without the need of external stirring or chemical and physical attachment of the enzyme. Ultra-fast detection (<2 min) and accurate quantifications of L-phenylalanine (L-Phe) in plasma and whole-blood newborns samples diagnosed with Phenylketonuria and total D-AAs in Vibrio cholera cultures are pioneer illustrated as relevant examples of each enantiomer determination. These results opens clearly novel avenues in biosensing for fast screening diagnostics, decentralized monitoring and design of future points of care.