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Gómez Gómez, Beatriz

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Beatriz
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Gómez Gómez
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https://hdl.handle.net/20.500.14352/82513
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Universidad Complutense de Madrid
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Author: Vicente Zurdo, David × Has files: true ×

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    Project number: 202
    ODS con mucha ciencia: Hacia una enseñanza STEM y más allá
    (2022) Gracia Lor, Emma; Blanco Asenjo, Miriam; Espada Bernabé, Elena; Fernández Bautista, Tamara; Gómez Castro, Emilio; Gómez Mejía, Esther; Gómez Gómez, Beatriz; Lorente Arévalo, Álvaro; Moreno Martín, Gustavo; Muñoz Olivas, María Riansares; Muñoz San Martín, Cristina; Oro Carretero, Paloma de; Pérez Corona, María Teresa; Romero Sánchez, Iván; Sacristán Navarro, Iván; Vicente Zurdo, David
    Memoria del proyecto de innovación titulado "ODS con mucha ciencia: Hacia una enseñanza STEM y más allá" de la convocatoria 2021-2022. El proyecto se ha centrado en fomentar el interés de los estudiantes de ESO y Bachillerato por la ciencia, proporcionándoles herramientas para que desarrollen competencias STEM a través de charlas de divulgación, talleres experimentales y sesiones de mentoría.
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    Cytotoxicity, uptake and accumulation of selenium nanoparticles and other selenium species in neuroblastoma cell lines related to Alzheimer’s disease by using cytotoxicity assays, TEM and single cell-ICP-MS
    (Analytica Chimica Acta, 2023) Vicente Zurdo, David; Gómez Gómez, Beatriz; Romero Sánchez, Iván; Rosales Conrado, Noelia; León González, María Eugenia De; Madrid Albarrán, María Yolanda; Elsevier B.V.
    Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease, representing 80% of the total dementia cases. The “amyloid cascade hypothesis” stablishes that the aggregation of the beta-amyloid protein (Aβ42) is the first event that subsequently triggers AD development. Selenium nanoparticles stabilized with chitosan (Ch-SeNPs) have demonstrated excellent anti-amyloidogenic properties in previous works, leading to an improvement of AD aetiology. Here, the in vitro effect of selenium species in AD model cell line has been study to obtain a better assessment of their effects in AD treatment. For this purpose, mouse neuroblastoma (Neuro-2a) and human neuroblastoma (SH-SY5Y) cell lines were used. Cytotoxicity of selenium species, such as selenomethionine (SeMet), Se-methylselenocysteine (MeSeCys) and Ch-SeNPs, has been determined by 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry methods. Intracellular localisation of Ch-SeNPs, and their pathway through SH-SY5Y cell line, have been evaluated by transmission electron microscopy (TEM). The uptake and accumulation of selenium species by both neuroblastoma cell lines have been quantified at single cell level by single cell- Inductively Coupled Plasma with Mass Spectrometry detection (SCICP-MS), with a previous optimisation of transport efficiency using gold nanoparticles (AuNPs) ((69 ± 3) %) and 2.5 mm calibration beads ((92 ± 8) %). Results showed that Ch-SeNPs would be more readily accumulated by both cell lines than organic species being accumulation ranges between 1.2 and 89.5 fg Se cell􀀀 1 for Neuro-2a and 3.1–129.8 fg Se cell1 for SH-SY5Y exposed to 250 μM Ch-SeNPs. Data obtained were statistically using chemometric tools. These results provide an important insight into the interaction of Ch-SeNPs with neuronal cells, which could support their potential use in AD treatment.
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    Aprendizaje-Servicio para trasladar los resultados desarrollo sostenible: del laboratorio a la sociedad
    (2021) Gracia Lor, Emma; Gómez Mejía, Esther; Moreno Martín, Gustavo; Gómez Gómez, Beatriz; Vicente Zurdo, David; Pérez Corona, María Teresa; Muñoz Olivas, María Riansares; Gómez Castro, Emilio
    El objetivo general planteado en este proyecto ha sido comunicar y concienciar a los estudiantes de secundaria y bachillerato sobre la necesidad de un desarrollo sostenible, con el fin de que sean capaces de comprender e identificar las problemáticas asociadas a los objetivos planteados en la Agenda 2030 y asociarlas con actividades propias de la vida cotidiana. De esta manera, los alumnos podrán adquirir herramientas de gran utilidad para el desarrollo de su futura vida personal y profesional. Para lograr dichos objetivos se han llevado a cabo una serie de actividades (charlas de divulgación científica, debates, uso de la aplicación Kahoot) en diferentes centros educativos no universitarios, en concreto, en tres institutos de educación secundaria y bachillerato (IES) y en un centro de educación de personas adultas (CEPA). Los temas tratados se encuadran dentro de los Objetivos de Desarrollo Sostenible (ODS) de la Agenda 2030, concretamente los ODS 2, 3 y 12.
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    Project number: 283
    La divulgación científica como herramienta para promover el desarrollo sostenible: de la universidad a la sociedad
    (2021) Gracia Lor, Emma; Muñoz Olivas, María Riansares; Pérez Corona, María Teresa; Gómez Castro, Emilio; Gómez Mejía, Esther; Moreno Martín, Gustavo; Vicente Zurdo, David; Gómez Gómez, Beatriz
    Memoria del proyecto de innovación titulado "La divulgación científica como herramienta para promover el desarrollo sostenible: de la universidad a la sociedad" de la convocatoria 2020-2021. El proyecto se ha centrado en promover una educación de calidad mediante la transferencia de conocimientos científicos relacionados con los Objetivos de Desarrollo Sostenible 2, 3 y 12 de la Agenda 2030 y el desarrollo de pensamiento crítico científico-divulgativo tanto del alumnado procedente de centros educativos de secundaria y bachillerato como de los estudiantes de universidad.
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    Impact of fish growing conditions and cooking methods on selenium species in swordfish and salmon fillets
    (Journal of Food Composition and Analysis, 2019) Vicente Zurdo, David; Gómez Gómez, Beatriz; Pérez Corona, María Teresa; Madrid Albarrán, María Yolanda
    This study evaluates the effect of fish growing conditions (captured fisheries or aquaculture) and cooking methods (fried, oven-baked and smoked) on selenium species distribution in fish fillets (salmon and swordfish). Fillets from 10 individual fishes for each fish species were analyzed. Selenium speciation was examined using HPLC–ICP–MS. Selenium in fillet samples was mainly present as organic selenium (around 93% of selenium content). Selenomethionine (SeMet) and selenocystine (SeCys2) were the main species found in salmon, regardless of its growing conditions (farmed or wild). However, SeCys2 was found at a higher concentration in wild salmon fillets. Concerning swordfish, SeMet, SeCys2 and selenomethylselenocysteine (SeMetSeCys) were detected and quantified. New selenium species were not produced when fillets were cooked. However, differences in selenium species distribution were observed for some fishes and/or treatments. Baking led to a notable increase of SeMetSeCys in swordfish (68% of the total selenium), in comparison with the amount of SeMetSeCys found in raw fish (17% of total selenium), whereas a notable decrease of SeCys2 occurred when salmon was submitted to the different cooking techniques. In contrast, smoked salmon provided a selenium species distribution similar to that of raw farmed salmon.