Person:
Benito León, Julián

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First Name
Julián
Last Name
Benito León
URI
https://hdl.handle.net/20.500.14352/80941
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Medicina
Area
Medicina
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End date: 2019 × Start date: 2019 ×

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    Graph theory analysis of resting‐state functional magnetic resonance imaging in essential tremor
    (Human Brain Mapping, 2019) Benito León, Julián; Sanz‐Morales, Emilio; Melero Carrasco, Helena; Louis, Elan D.; Romero, Juan P.; Rocon, Eduardo; Malpica, Norberto
    Essential tremor (ET) is a neurological disease with both motor and nonmotor manifestations; however, little is known about its underlying brain basis. Furthermore, the overall organization of the brain network in ET remains largely unexplored. We investigated the topological properties of brain functional network, derived from resting‐state functional magnetic resonance imaging (MRI) data, in 23 ET patients versus 23 healthy controls. Graph theory analysis was used to assess the functional network organization. At the global level, the functional network of ET patients was characterized by lower small‐worldness values than healthy controls—less clustered functionality of the brain. At the regional level, compared with the healthy controls, ET patients showed significantly higher values of global efficiency, cost and degree, and a shorter average path length in the left inferior frontal gyrus (pars opercularis), right inferior temporal gyrus (posterior division and temporo‐occipital part), right inferior lateral occipital cortex, left paracingulate, bilateral precuneus bilaterally, left lingual gyrus, right hippocampus, left amygdala, nucleus accumbens bilaterally, and left middle temporal gyrus (posterior part). In addition, ET patients showed significant higher local efficiency and clustering coefficient values in frontal medial cortex bilaterally, subcallosal cortex, posterior cingulate cortex, parahippocampal gyri bilaterally (posterior division), right lingual gyrus, right cerebellar flocculus, right postcentral gyrus, right inferior semilunar lobule of cerebellum and culmen of vermis. Finally, the right intracalcarine cortex and the left orbitofrontal cortex showed a shorter average path length in ET patients, while the left frontal operculum and the right planum polare showed a higher betweenness centrality in ET patients. In conclusion, the efficiency of the overall brain functional network in ET is disrupted. Further, our results support the concept that ET is a disorder that disrupts widespread brain regions, including those outside of the brain regions responsible for tremor.
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    Project number: 204
    Curso de formación de profesorado en estructura departamental
    (2019) Collado Yurrita, Luis Rodolfo; Ciudad Cabañas, María José; Hernández Gallego, Jesús; Gomez-Lus Centelles, Maria Luisa; Tejedor Jorge, Alberto; Madrigal Martínez-Pereda, Cristina María; Alou Cervera, Luis; Sevillano Fernández, David; Benito León, Julián; Cuenca Caraballo, Maigualida; García Chacón, Marta; Oconnor de la Oliva, Anna; Marín Cuenda, María José; Roiz Sastrón, María del Carmen; San Mauro Martín, Ismael; Marín Viecho, Julia; Muñoz Lucas, María Angeles; Nieto Barbero, Maria Asunción; Callol Sánchez, Luis Miguel; Sanz Esporrín, Javier; García Torrent, María Jesús; Cuadrado Cenzual, María Ángeles
    El Proyecto propuesto es un Programa Formacion del Profesorado en Dirección y Gestión de Departamentos Universitarios dirigido al PDI, con apoyo del PAS, con la finalidad de obtener un cierto grado de profesionalización en Dirección Departamental.