Person:
Iborra Martín, Salvador

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First Name
Salvador
Last Name
Iborra Martín
URI
https://hdl.handle.net/20.500.14352/84509
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Inmunología, Oftalmología y ORL
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Author: Hernández García, Elena × Has files: true ×

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    Inoculation of the Leishmania infantum HSP70-II Null Mutant Induces Long-Term Protection against L. amazonensis Infection in BALB/c Mice
    (Microorganisms, 2021) Soto, Manuel; Ramírez, Laura; Solana, José Carlos; Cook, Emma C. L.; Hernández García, Elena; Requena, José María; Iborra Martín, Salvador
    Leishmania amazonensis parasites are etiological agents of cutaneous leishmaniasis in the New World. BALB/c mice are highly susceptible to L. amazonensis challenge due to their inability to mount parasite-dependent IFN-γ-mediated responses. Here, we analyzed the capacity of a single administration of the LiΔHSP70-II genetically-modified attenuated L. infantum line in preventing cutaneous leishmaniasis in mice challenged with L. amazonensis virulent parasites. In previous studies, this live attenuated vaccine has demonstrated to induce long-protection against murine leishmaniasis due to Old World Leishmania species. Vaccinated mice showed a reduction in the disease evolution due to L. amazonensis challenge, namely reduction in cutaneous lesions and parasite burdens. In contrast to control animals, after the challenge, protected mice showed anti-Leishmania IgG2a circulating antibodies accompanied to the induction of Leishmania-driven specific IFN-γ systemic response. An analysis performed in the lymph node draining the site of infection revealed an increase of the parasite-specific IFN-ϒ production by CD4+ and CD8+ T cells and a decrease in the secretion of IL-10 against leishmanial antigens. Since the immunity caused by the inoculation of this live vaccine generates protection against different forms of murine leishmaniasis, we postulate LiΔHSP70-II as a candidate for the development of human vaccines.
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    Project number: 238
    Presentación y discusión de trabajos científicos de respuesta inmune a la infección en congresos
    () García de Yébenes Mena, Virginia; Roda Navarro, Pedro; Iborra Martín, Salvador; Fernández Messina, Lola María; Fernandez Arquero, Miguel; Álvarez Corrales, Emigdio; Redondo Urzainqui, Ana; Hernández García, Elena; Aguilar Sopeña, Óscar; Carrasco Padilla, Carlos
    El proyecto ha tenido como objetivo proporcionar a los alumnos del máster de Investigación en Inmunología de la UCM una formación teórica y práctica para la presentación de trabajos científicos en congresos. Se ha desarrollado una reunión científica en la que los alumnos han presentado y discutido trabajos científicos relevantes relacionados con la asignatura “Interacción Patógeno Sistema Inmunitario (607653)” en los formatos de presentación oral y presentación en póster que se utilizan en las reuniones científicas