Person:
Mazariegos Martínez-Peñalver, María

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First Name
María
Last Name
Mazariegos Martínez-Peñalver
Affiliation
Universidad Complutense de Madrid
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Now showing 1 - 3 of 3
  • Publication
    Gene expression profile suggests that pigs (Sus scrofa) are susceptible to Anaplasma phagocytophilum but control infection
    (BioMedCentral, 2012-08-30) Galindo, Ruth C; Ayllón, Nieves; Smrdel, Katja Strašek; Boadella, Mariana; Beltrán-Beck, Beatriz; Mazariegos Martínez-Peñalver, María; García Benzaquén, Nerea; de la Lastra, José M Pérez; Avsic-Zupanc, Tatjana; Kocan, Katherine M; Gortazar, Christian; de la Fuente, José
    BACKGROUND Anaplasma phagocytophilum infects a wide variety of hosts and causes granulocytic anaplasmosis in humans, horses and dogs and tick-borne fever in ruminants. Infection with A. phagocytophilum results in the modification of host gene expression and immune response. The objective of this research was to characterize gene expression in pigs (Sus scrofa) naturally and experimentally infected with A. phagocytophilum trying to identify mechanisms that help to explain low infection prevalence in this species. RESULTS For gene expression analysis in naturally infected pigs, microarray hybridization was used. The expression of differentially expressed immune response genes was analyzed by real-time RT-PCR in naturally and experimentally infected pigs. Results suggested that A. phagocytophilum infection affected cytoskeleton rearrangement and increased both innate and adaptive immune responses by up regulation of interleukin 1 receptor accessory protein-like 1 (IL1RAPL1), T-cell receptor alpha chain (TCR-alpha), thrombospondin 4 (TSP-4) and Gap junction protein alpha 1 (GJA1) genes. Higher serum levels of IL-1 beta, IL-8 and TNF-alpha in infected pigs when compared to controls supported data obtained at the mRNA level. CONCLUSIONS These results suggested that pigs are susceptible to A. phagocytophilum but control infection, particularly through activation of innate immune responses, phagocytosis and autophagy. This fact may account for the low infection prevalence detected in pigs in some regions and thus their low or no impact as a reservoir host for this pathogen. These results advanced our understanding of the molecular mechanisms at the host-pathogen interface and suggested a role for newly reported genes in the protection of pigs against A. phagocytophilum.
  • Publication
    BIOSLab 2.0: la bioseguridad más allá del laboratorio
    (2021-12-29) Pérez Sancho, Marta; Álvarez Sánchez, Julio; Bezos Garrido, Javier; Domínguez Rodríguez, Lucas José; García Benzaquén, Nerea; García-Seco Romero, María Teresa; González Domínguez, Sergio; de Juan Ferré, Lucía; Mazariegos Martínez-Peñalver, María
    Complementación y actualización de la plataforma BIOSLab de formación on line en bioseguridad con material didáctico básico para la comunidad universitaria en el actual escenario de pandemia, y especializado para alumnos y profesionales de la salud.
  • Publication
    Infequus: plataforma de enfermedades infecciosas equinas
    (2019-04-12) de Juan Ferré, Lucía; Briones Dieste, Víctor; Bezos Garrido, Javier; Forés Jackson, Paloma; Camino Gutiérrez, Eliazar; Buendía Andrés, Aranzazu; Dorrego Rodríguez, Abel; Cruz López, Fatima; González Domínguez, Sergio; Romero Martínez, Beatriz; García Benzaquén, Nerea; Bárcena Asensio, Carmen; Mazariegos Martínez-Peñalver, María; Ancochea Nodal, Carlos; Hernández Carrillo, Javier; Pérez Sancho, Marta; Pérez Sancho, Marta
    Desarrollo de la herramienta de formación online Infequus, que ofrecerá a los alumnos y profesionales información actualizada sobre el diagnóstico y control de las enfermedades infecciosas en la especie equina.