Person: Peña Melián, Ángel
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First Name
Ángel
Last Name
Peña Melián
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Area
Anatomía y Embriología Humana
Identifiers
5 results
Search Results
Now showing 1 - 5 of 5
Item Grapheme-color synesthetes show peculiarities in their emotional brain: cortical and subcortical evidence from VBM analysis of 3D-T1 and DTI data(Experimental Brain Research, 2013) Ríos-Lago, M.; Pajares, G.; Hernández-Tamames, J. A.; Álvarez-Linera, J.; Melero Carrasco, Helena; Peña Melián, ÁngelGrapheme-color synesthesia is a neurological phenomenon in which viewing achromatic letters/numbers leads to automatic and involuntary color experiences. In this study, voxel-based morphometry analyses were performed on T1 images and fractional anisotropy measures to examine the whole brain in associator grapheme-color synesthetes. These analyses provide new evidence of variations in emotional areas (both at the cortical and subcortical levels), findings that help understand the emotional component as a relevant aspect of the synesthetic experience. Additionally, this study replicates previous findings in the left intraparietal sulcus and, for the first time, reports the existence of anatomical differences in subcortical gray nuclei of developmental grapheme-color synesthetes, providing a link between acquired and developmental synesthesia. This empirical evidence, which goes beyond modality-specific areas, could lead to a better understanding of grapheme-color synesthesia as well as of other modalities of the phenomenon.Item Achromatic synesthesias - A functional magnetic resonance imaging study(NeuroImage, 2014) Melero Carrasco, Helena; Ríos-Lago, M.; Peña Melián, Ángel; Álvarez-Linera, J.Grapheme–color synesthetes experience consistent, automatic and idiosyncratic colors associated with specific letters and numbers. Frequently, these specific associations exhibit achromatic synesthetic qualities (e.g. white, black or gray). In this study, we have investigated for the first time the neural basis of achromatic synesthesias, their relationship to chromatic synesthesias and the achromatic congruency effect in order to understand not only synesthetic color but also other components of the synesthetic experience. To achieve this aim, functional magnetic resonance imaging experiments were performed in a group of associator grapheme–color synesthetes and matched controls who were stimulated with real chromatic and achromatic stimuli (Mondrians), and with letters and numbers that elicited different types of grapheme–color synesthesias (i.e. chromatic and achromatic inducers which elicited chromatic but also achromatic synesthesias, as well as congruent and incongruent ones). The information derived from the analysis of Mondrians and chromatic/achromatic synesthesias suggests that real and synesthetic colors/achromaticity do not fully share neural mechanisms. The whole-brain analysis of BOLD signals in response to the complete set of synesthetic inducers revealed that the functional peculiarities of the synesthetic brain are distributed, and reflect different components of the synesthetic experience: a perceptual component, an (attentional) feature binding component, and an emotional component. Additionally, the inclusion of achromatic experiences has provided new evidence in favor of the emotional binding theory, a line of interpretation which constitutes a bridge between grapheme–color synesthesia and other developmental modalities of the phenomenon.- Project number: 102
Item Anatomía Comparada del Aparato Genital Masculino de Mamíferos Domésticos. Herramienta de Aprendizaje Virtual para Veterinarios, Biólogos y Médicos(2018) Santos Álvarez, Inmaculada; Blánquez Layunta, María José; Pérez Lloret, Pilar; Martínez Sainz, María Del Pilar; Peña Melián, Ángel; Mateos Sanz, María Aránzazu; Hernández de Miguel, José MaríaEsta aplicación es una herramienta útil para estudiantes y profesores de diferentes campos. Permitirá conocer y estudiar el aparato genital masculino, señalando gráficamente la estructura a memorizar, ver su contenido teórico y autoevaluarse. - Project number: 19
Item Anatomía comparada del aparato urinario de mamíferos domésticos. Herramienta de aprendizaje virtual para veterinarios, biólogos y médicos.(2017) Santos Álvarez, Inmaculada; Blánquez Layunta, María José; Pérez Lloret, Pilar; Marín García, María Del Pilar; Peña Melián, Ángel; Arenas Jiménez, María Isabel; Viejo Jiménez, Óscar; Mateos Sanz, María AránzazuEsta aplicación es una herramienta útil para estudiantes, profesores y profesionales de diferentes campos. Permitirá conocer y estudiar el aparato urinario, señalando gráficamente la estructura a memorizar, ver su contenido teórico y autoevaluarse. Item Low and high dietary folic acid levels perturb postnatal cerebellar morphology in growing rats(British journal of nutrition, 2016) Partearroyo Cediel, Teresa; Pérez Miguelsanz, Juliana; Peña Melián, Ángel; Maestro De Las Casas, María Del Carmen; Úbeda Martín, Natalia; Valera Moreiras, GregorioThe brain is particularly sensitive to folate metabolic disturbances, because methyl groups are critical for brain functions. This study aimed to investigate the effects of different dietary levels of folic acid (FA) on postnatal cerebellar morphology, including the architecture and organisation of the various layers. A total of forty male OFA rats (a Sprague–Dawley strain), 5 weeks old, were classified into the following four dietary groups: FA deficient (0 mg/kg FA); FA supplemented (8 mg/kg FA); FA supra-supplemented (40 mg/kg FA); and control (2 mg/kg FA) (all n 10 per group). Rats were fed ad libitum for 30 d. The cerebellum was quickly removed and processed for histological and immunohistochemical analysis. Slides were immunostained for glial fibrillary acidic protein (to label Bergmann glia), calbindin (to label Purkinje cells) and NeuN (to label post-mitotic neurons). Microscopic analysis revealed two types of defect: partial disappearance of fissures and/or neuronal ectopia, primarily in supra-supplemented animals (incidence of 80 %, P≤0·01), but also in deficient and supplemented groups (incidence of 40 %, P≤0·05), compared with control animals. The primary fissure was predominantly affected, sometimes accompanied by defects in the secondary fissure. Our findings show that growing rats fed an FA-modified diet, including both deficient and supplemented diets, have an increased risk of disturbances in cerebellar corticogenesis. Defects caused by these diets may have functional consequences in later life. The present study is the first to demonstrate that cerebellar morphological defects can arise from deficient, as well as high, FA levels in the diet.