Person:
Ortega Aranegui, Ricardo

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First Name
Ricardo
Last Name
Ortega Aranegui
URI
https://hdl.handle.net/20.500.14352/79872
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Odontología
Department
Especialidades Clínicas Odontológicas
Area
Estomatología
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    Maxillary growth in a congenital cleft palate canine model for surgical research
    (Journal of Cranio-Maxillofacial Surgery, 2014) Paradas Lara, Irene; Casado Gómez, Inmaculada; Martín, Conchita; Martínez Sanz, Elena; López Gordillo, Yamila; González, Pablo; Rodríguez Bobada, Cruz; Chamorro, Manuel; Arias, Pablo; Maldonado Bautista, Estela; Ortega Aranegui, Ricardo; Berenguer, Beatriz; Martínez Álvarez, María Concepción
    We have recently presented the Old Spanish Pointer dog, with a 15-20% spontaneous congenital cleft palate rate, as a unique experimental model of this disease. This study aimed to describe the cleft palate of these dogs for surgical research purposes and to determine whether congenital cleft palate influences maxillofacial growth. Seven newborn Old Spanish Pointer dogs of both sexes, comprising a cleft palate group (n = 4) and a normal palate group (n = 3), were fed using the same technique. Macroscopic photographs and plaster casts from the palate, lateral radiographs and computer tomograms of the skull were taken sequentially over 41 weeks, starting at week 5. The cleft morphology, the size and the tissue characteristics in these dogs resembled the human cleft better than current available animal models. During growth, the cleft width varies. Most of the transverse and longitudinal measures of the palate were statistically lower in the cleft palate group. The cleft palate group showed hypoplasia of the naso-maxillary complex. This model of congenital cleft palate seems suitable for surgical research purposes. A reduced maxillofacial pre- and post-natal development is associated to the congenital cleft palate in the Old Spanish Pointer dog.