Person:
García Ortega, Lucía

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First Name
Lucía
Last Name
García Ortega
URI
https://hdl.handle.net/20.500.14352/76211
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Bioquímica y Biología Molecular
Area
Bioquímica y Biología Molecular
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Author: Pérez Gil, Jesús × Subject: 616.2 ×

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    Pulmonary surfactant-derived antiviral actions at the respiratory surface
    (Current Opinion in Colloid & Interface Science, 2023) Isasi Campillo, Miriam; Losada Oliva, Paula; Pérez Gil, Jesús; Olmeda Lozano, Bárbara; García Ortega, Lucía
    Lung surfactant (LS) is a membrane-based lipid-protein complex that lines the alveoli, reducing the surface tension at the air-liquid interface and thus minimizing the work of breathing. Besides this function, LS is also the first physical barrier between the outside air and the systemic circulation, therefore playing a key role in the defense against harmful particles and microorganisms. Viral respiratory tract infections (RTIs), and especially acute lower RTIs, are one of the leading causes of morbidity and mortality worldwide. LS participates in the network of interactions between viruses and the immune system to prevent or lessen the effects of the infection, but it is also altered by these pathogens, which can potentially impair its function. The aim of this review is to provide an integrated multidisciplinary overview toward understanding the interplay between respiratory viruses and LS and its health impact on the respiratory system. The review is centered on the antiviral mechanisms of both LS proteins and lipids, and their different interactions that lead to varying outcomes. Finally, a summary of the clinical application of surfactant in the scene of lung viral infection is disclosed, including state-of-the-art approaches of the therapeutic use of surfactant components.