Person:
Crooke Álvarez, Almudena

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First Name
Almudena
Last Name
Crooke Álvarez
URI
https://hdl.handle.net/20.500.14352/79888
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Óptica y Optometría
Department
Bioquímica y Biología Molecular
Area
Bioquímica y Biología Molecular
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UCM identifierORCIDScopus Author IDDialnet IDGoogle Scholar ID

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20211
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Author: Ruiz Alcocer, Javier × Subject: 612.112.91: 616-074 ×

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    Neutrophils and neutrophil extracellular trap components: Emergingbiomarkers and therapeutic targets for age-related eye diseases
    (Ageing Research Reviews, 2021) Martínez Alberquilla, Irene; Gasull, Xavier; Pérez Luna, Patricia; Seco Mera, Rubén; Ruiz Alcocer, Javier; Crooke Álvarez, Almudena
    Age-related eye diseases, including dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy, represent a major global health issue based on their increasing prevalence and disabling action. Unraveling the molecular mechanisms underlying these diseases will provide novel opportunities to reduce the burden of age-related eye diseases and improve eye health, contributing to sustainable development goals achievement. The impairment of neutrophil extracellular traps formation/degradation processes seems to be one of these mechanisms. These traps formed by a meshwork of DNA and neutrophil cytosolic granule proteins may exacerbate the inflammatory response promoting chronic inflammation, a pivotal cause of age-related diseases.In this review, we describe current findings that suggest the role of neutrophils and their traps in the pathogenesis of the above-mentioned age-related eye diseases. Furthermore, we discuss why these cells and their constituents could be biomarkers and therapeutic targets for dry eye, glaucoma, age-related macular degeneration, and diabetic retinopathy. We also examine the therapeutic potential of some neutrophil function modulators and provide several recommendations for future research in age-related eye diseases