Person:
Casals Carro, María Cristina

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First Name
María Cristina
Last Name
Casals Carro
URI
https://hdl.handle.net/20.500.14352/76127
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Bioquímica y Biología Molecular
Area
Bioquímica y Biología Molecular
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Author: Allen, Judith ×

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    Local amplifiers of IL-4Rα–mediated macrophage activation promote repair in lung and liver
    (Science, 2017) Minutti, Carlos; Jackson-Jones, Lucy; García-Fojeda García-Valdecasas, María Belén; Knipper, Johanna ; Sutherland, Tara; Logan, Nicola; Ringqvist, Emma; Guillamat-Prats, Raquel; Ferenbach, David; Artigas, Antonio; Stamme, Cordula ; Chroneos, Zissis ; Zaiss, Dietmar ; Casals Carro, María Cristina; Allen, Judith
    The type 2 immune response controls helminth infection and maintains tissue homeostasis but can lead to allergy and fibrosis if not adequately regulated. We have discovered local tissue-specific amplifiers of type 2-mediated macrophage activation. In the lung, surfactant protein A (SP-A) enhanced interleukin-4 (IL-4)-dependent macrophage proliferation and activation, accelerating parasite clearance and reducing pulmonary injury after infection with a lung-migrating helminth. In the peritoneal cavity and liver, C1q enhancement of type 2 macrophage activation was required for liver repair after bacterial infection, but resulted in fibrosis after peritoneal dialysis. IL-4 drives production of these structurally related defense collagens, SP-A and C1q, and the expression of their receptor, myosin 18A. These findings reveal the existence within different tissues of an amplification system needed for local type 2 responses.