Person:
Lorenzo González, Pedro Luis

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First Name
Pedro Luis
Last Name
Lorenzo González
URI
https://hdl.handle.net/20.500.14352/80485
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Fisiología
Area
Fisiología
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End date: 2024 × Subject: 61 ×

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    The effects of sildenafil citrate on feto–placental development and haemodynamics in a rabbit model of intrauterine growth restriction
    (Reproduction, Fertility and Development, 2017) López-Tello, Jorge; Arias Álvarez, María; Jiménez Martínez, María De Los Ángeles; Barbero-Fernández, Alicia; García García, Rosa María; María Rodríguez; Lorenzo González, Pedro Luis; Torres-Rovira, Laura; Astiz, Susana; González-Bulnes, Antonio; Rebollar, Pilar G.
    The present study evaluated the effectiveness of sildenafil citrate (SC) to improve placental and fetal growth in a diet-induced rabbit model of intrauterine growth restriction (IUGR). Pregnant rabbits were fed either ad libitum (Group C) or restricted to 50% of dietary requirements (Group R) or restricted and treated with SC (Group SC). The treatment with SC improved placental development by increasing vascularity and vessel hypertrophy in the decidua. The assessment of feto-placental haemodynamics showed higher resistance and pulsatility indices at the middle cerebral artery (MCA) in fetuses treated with SC when compared with Group R, which had increased systolic peak and time-averaged mean velocities at the MCA. Furthermore, fetuses in the SC group had significantly higher biparietal and thoracic diameters and longer crown-rump lengths than fetuses in Group R. Hence, the SC group had a reduced IUGR rate and a higher kit size at birth compared with Group R. In conclusion, SC may provide potential benefits in pregnancies with placental insufficiency and IUGR, partially counteracting the negative effects of food restriction on placental development and fetal growth. However, the present study also found evidence of a possible blood overflow in the brain that warrants further investigation.