Person:
Herrero Vanrell, María Del Rocío

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First Name
María Del Rocío
Last Name
Herrero Vanrell
URI
https://hdl.handle.net/20.500.14352/77475
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Farmacia Galénica y Tecnología Alimentaria
Area
Farmacia y Tecnología Farmaceútica
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2010 - 20183
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Author: Arriola Villalobos, Pedro × Has files: true ×

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Now showing 1 - 3 of 3
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    Comparative Analysis of Carmellose 0.5% Versus Hyaluronate 0.15% in Dry Eye: A Flow Cytometric Study
    (Cornea, 2010) Sánchez Tena, Miguel Ángel; Torralbo Jiménez, Pilar ; Giron, Natalia ; De la Heras, Beatriz; Herrero Vanrell, María Del Rocío; Arriola Villalobos, Pedro; Díaz Valle, David; Álvarez Barrientos, Alberto ; Benítez Del Castillo Sánchez, José Manuel
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    Novel Nano-Liposome Formulation for Dry Eyes with Components Similar to the Preocular Tear Film
    (Polymers, 2018) Vicario De La Torre, Marta; Caballo González, María; Vico Ruiz, Eva; Morales Fernández, Laura; Arriola Villalobos, Pedro; Heras Polo, Beatriz De Las; Benítez Del Castillo Sánchez, José Manuel; Guzmán Navarro, Manuel; Millar, Thomas; Herrero Vanrell, María Del Rocío; Molina Martínez, Irene Teresa
    Dry eye is commonly treated with artificial tears; however, developing artificial tears similar to natural tears is difficult due to the complex nature of tears. We characterized and evaluated a novel artificial tear formulation with components similar to the lipid and aqueous constituents of natural tears. Nano-liposomes, composed in part of phosphatidylcholine, were dispersed in an aqueous solution of bioadhesive sodium hyaluronate. Liposome size, zeta potential, and physicochemical properties of the fresh and stored (4°C) liposomal formulation were analyzed. In vitro tolerance was tested using human corneal and conjunctival cell lines by exposures of 15 min to 4 h. The tolerance of the liposomal formulation was evaluated in animals (rabbits). The average liposome size was 186.3 +/- 7.0 nm, and the zeta potential was negative. The osmolarity of the formulation was 198.6 +/- 1.7 mOsm, with a surface tension of 36.5 +/- 0.4 mN/m and viscosity of 3.05 +/- 0.02 mPa·s. Viability values in the human corneal and conjunctival cell lines were always >80%, even after liposomal formulation storage for 8 weeks. Discomfort and clinical signs after instillation in rabbit eyes were absent. The new formulation, based on phosphatidylcholine-liposomes dispersed in sodium hyaluronate has suitable components and characteristics, including high in vitro cell viability and good in vivo tolerance, to serve as a tear substitute.
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    The effect of preservative-free HP-Guar on dry eye after phaco- emulsification: a flow cytometric study
    (2010) Sánchez Tena, Miguel Ángel; Torralbo Jiménez, P. ; Giron, N. ; De la Heras, B. ; Herrero Vanrell, María Del Rocío; Álvarez Barrientos. A. ; Benítez Del Castillo Sánchez, José Manuel; Arriola Villalobos, Pedro
    Purpose To assess the effect of hydroxypropyl (HP)-Guar added to regular post-phacoemulsification treatment in dry eye signs and symptoms, and its influence on the expression of various inflammatory markers by flow cytometry (FCM) in impression cytology specimens. Methods This prospective, interventional, single-centre study included 48 eyes of 48 patients with age-related cataract. After phacoemulsification, patients were randomised to the usual treatment group (UT), with 21 patients who received tobramycin and dexamethasone eye drops (Tobradex, Alcon Cusı´, Spain), and the HP-Guargroup, with 27 patients who received the UT plus preservative-free artificial tears (Systane UD, Alcon Cusı´, Spain). Corneal and conjunctival staining with fluorescein and lissamine green, tear film break-up time (TBUT), Schirmer’s I test with anaesthesia (Jones test), tear clearance, and ocular surface disease index (OSDI) were assessed preoperatively and 1 month after surgery. Besides, conjunctival impression cytology was performed in order to investigate inflammatory markers (CD3, CD11b, and HLA-DR) using FCM. Results HP-Guar group shows statistical better results compared with the UT group in TBUT (6.4±0.7 vs 9±2.5, P ¼ 0.0004), OSDI (11.5±8.2 vs 3.3±2.5, P ¼ 0.0002), ocular symptoms subscale (7.3±6.1 vs 1.7±1.8, P ¼ 0.0004), vision-related function subscale (2.2±1.8 vs 0.4±0.6, P ¼ 0.0002), CD3 (2.5±1.4 vs 1.1±1.1, P ¼ 0.011), and HLA-DR (6.8±4.5 vs 1.8±1.7, P ¼ 0.0002).