Person:
Herrero Vanrell, María Del Rocío

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First Name
María Del Rocío
Last Name
Herrero Vanrell
URI
https://hdl.handle.net/20.500.14352/77475
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Farmacia Galénica y Tecnología Alimentaria
Area
Farmacia y Tecnología Farmaceútica
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Author: Sánchez Tena, Miguel Ángel × Has files: true ×

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    Comparative Analysis of Carmellose 0.5% Versus Hyaluronate 0.15% in Dry Eye: A Flow Cytometric Study
    (Cornea, 2010) Sánchez Tena, Miguel Ángel; Torralbo Jiménez, Pilar ; Giron, Natalia ; De la Heras, Beatriz; Herrero Vanrell, María Del Rocío; Arriola Villalobos, Pedro; Díaz Valle, David; Álvarez Barrientos, Alberto ; Benítez Del Castillo Sánchez, José Manuel
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    The effect of preservative-free HP-Guar on dry eye after phaco- emulsification: a flow cytometric study
    (2010) Sánchez Tena, Miguel Ángel; Torralbo Jiménez, P. ; Giron, N. ; De la Heras, B. ; Herrero Vanrell, María Del Rocío; Álvarez Barrientos. A. ; Benítez Del Castillo Sánchez, José Manuel; Arriola Villalobos, Pedro
    Purpose To assess the effect of hydroxypropyl (HP)-Guar added to regular post-phacoemulsification treatment in dry eye signs and symptoms, and its influence on the expression of various inflammatory markers by flow cytometry (FCM) in impression cytology specimens. Methods This prospective, interventional, single-centre study included 48 eyes of 48 patients with age-related cataract. After phacoemulsification, patients were randomised to the usual treatment group (UT), with 21 patients who received tobramycin and dexamethasone eye drops (Tobradex, Alcon Cusı´, Spain), and the HP-Guargroup, with 27 patients who received the UT plus preservative-free artificial tears (Systane UD, Alcon Cusı´, Spain). Corneal and conjunctival staining with fluorescein and lissamine green, tear film break-up time (TBUT), Schirmer’s I test with anaesthesia (Jones test), tear clearance, and ocular surface disease index (OSDI) were assessed preoperatively and 1 month after surgery. Besides, conjunctival impression cytology was performed in order to investigate inflammatory markers (CD3, CD11b, and HLA-DR) using FCM. Results HP-Guar group shows statistical better results compared with the UT group in TBUT (6.4±0.7 vs 9±2.5, P ¼ 0.0004), OSDI (11.5±8.2 vs 3.3±2.5, P ¼ 0.0002), ocular symptoms subscale (7.3±6.1 vs 1.7±1.8, P ¼ 0.0004), vision-related function subscale (2.2±1.8 vs 0.4±0.6, P ¼ 0.0002), CD3 (2.5±1.4 vs 1.1±1.1, P ¼ 0.011), and HLA-DR (6.8±4.5 vs 1.8±1.7, P ¼ 0.0002).