Person:
Jiménez Meléndez, Alejandro

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First Name
Alejandro
Last Name
Jiménez Meléndez
URI
https://hdl.handle.net/20.500.14352/86851
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Sanidad Animal
Area
Sanidad Animal
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2016 - 201922020 - 20241
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Author: Ferré Pérez, Ignacio × Start date: 2016 ×

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Now showing 1 - 3 of 3
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    Project number: 290
    Parasitología Interactiva
    (2016) Gómez Bautista, Mercedes; Ortega Mora, Luis Miguel; Álvarez García, Gema; Ferré Pérez, Ignacio; Moreno Gonzalez, Javier; Gutierrez Expósito, Daniel; Arranz-Solís, David; Pastor Fernández, Iván; Rojo Montejo, Silvia; Sánchez Sánchez, Roberto; García Lunar, Paula; Jiménez Meléndez, Alejandro; Jimenez Pelayo, Laura; García Sánchez, Marta; Diezma Díaz, Carlos; Horcajo Iglesias, María Del Pilar; Regidor Cerrillo, Javier; Pérez Villalobos, Natividad; Collantes Fernández, Esther
    Desarrollo de una guía interactiva donde se muestran los ciclos biológicos,imágenes y dibujos de los estadios evolutivos de los principales géneros y especies de parásitos protozoos relevantes en al ámbito veterinario.
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    Project number: 262
    Parasitología interactiva: Protozoos y afines
    (2018) Collantes Fernández, Esther; Gómez Bautista, Mercedes; Ortega Mora, Luis Miguel; Álvarez García, Gema; Ferré Pérez, Ignacio; García Lunar, Paula; Sánchez Sánchez, Roberto; Jiménez Meléndez, Alejandro; García Sánchez, Marta; Jiménez Pelayo, Laura; Diezma Díaz, Carlos; Regidor Cerrillo, Javier; Moreno González, Javier; Horcajo Iglesias, María Del Pilar
    Desarrollo de una guía interactiva donde se muestran los ciclos biológicos, imágenes y dibujos de los estadios evolutivos de los principales géneros y especies de parásitos protozoos relevantes en al ámbito veterinario.
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    Transcriptomics of Besnoitia besnoiti-Infected Fibroblasts Reveals Hallmarks of Early Fibrosis and Cancer Progression
    (Microorganisms, 2024) Fernández Álvarez, María; Horcajo Iglesias, María Del Pilar; Jiménez Meléndez, Alejandro; Ferré Pérez, Ignacio; Ortega Mora, Luis Miguel; Álvarez García, Gema; Angulo Lara, Pablo; Huertas López, Ana; Huertas López, Francisco
    Endothelial injury, inflammatory infiltrate and fibrosis are the predominant lesions in the testis of bulls with besnoitiosis that may result in sterility. Moreover, fibroblasts, which are key players in fibrosis, are parasite target cells in a Besnoitia besnoiti chronic infection. This study aimed to decipher the molecular basis that underlies a drift toward fibrosis during the disease progression. Transcriptomic analysis was developed at two times post-infection (p.i.), representative of invasion (12 h p.i.) and intracellular proliferation (32 h p.i.), in primary bovine aorta fibroblasts infected with B. besnoiti tachyzoites. Once the enriched host pathways were identified, we studied the expression of selected differentially expressed genes (DEGs) in the scrotal skin of sterile infected bulls. Functional enrichment analyses of DEGs revealed shared hallmarks of cancer and early fibrosis. Biomarkers of inflammation, angiogenesis, cancer, and MAPK signaling stood out at 12 h p.i. At 32 h p.i., again MAPK and cancer pathways were enriched together with the PI3K–AKT pathway related to cell proliferation. Some DEGs were also regulated in the skin samples of naturally infected bulls (PLAUR, TGFβ1, FOSB). We have identified potential biomarkers and host pathways regulated during fibrosis that may hold prognostic significance and could emerge as potential therapeutic targets.