Person:
Rubio Retama, Benito Jorge

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First Name
Benito Jorge
Last Name
Rubio Retama
URI
https://hdl.handle.net/20.500.14352/77471
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Química en Ciencias Farmacéuticas
Area
Química Física
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Author: Méndez González, Diego × Subject: 535.37 ×

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    Ion-induced bias in Ag2S luminescent nanothermometers
    (Nanoscale, 2023) París Ogayar, Marina; Méndez González, Diego; Zabala Gutiérrez, Irene; Artiga , Alvaro; Rubio Retama, Benito Jorge; Gómez Calderón, Óscar; Melle Hernández, Sonia; Alda Serrano, Javier; Espinosa, Ana; Jaque, Daniel; Marín Viadel, Ricardo
    Luminescence nanothermometry allows measuring temperature remotely and in a minimally invasive way by using the luminescence signal provided by nanosized materials. This technology has allowed, for example, the determination of intracellular temperature and in vivo monitoring of thermal processes in animal models. However, in the biomedical context, this sensing technology is crippled by the presence of bias (cross-sensitivity) that reduces the reliability of the thermal readout. Bias occurs when the impact of environmental conditions different from temperature also modifies the luminescence of the nanothermometers. Several sources that cause loss of reliability have been identified, mostly related to spectral distortions due to interaction between photons and biological tissues. In this work, we unveil an unexpected source of bias induced by metal ions. Specifically, we demonstrate that the reliability of Ag2S nanothermometers is compromised during the monitoring of photothermal processes produced by iron oxide nanoparticles. The observed bias occurs due to the heat-induced release of iron ions, which interact with the surface of the Ag2S nanothermometers, enhancing their emission. The results herein reported raise a warning to the community working on luminescence nanothermometry, since they reveal that the possible sources of bias in complex biological environments, rich in molecules and ions, are more numerous than previously expected.