Person:
Martín Adrados, Beatriz

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First Name
Beatriz
Last Name
Martín Adrados
URI
https://hdl.handle.net/20.500.14352/86251
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Inmunología, Oftalmología y ORL
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End date: 2019 × Start date: 2018 ×

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    Monocyte-Derived Dendritic Cells Differentiated in the Presence of Lenalidomide Display a Semi-Mature Phenotype, Enhanced Phagocytic Capacity, and Th1 Polarization Capability
    (Frontiers in Immunology, 2018) López Relaño,Juan; Martín Adrados, Beatriz; Real Arévalo, Irene; Lozano Bartolomé, Javier; Abós, Beatriz; Sánchez Ramón, Silvia María; Alonso, Bárbara; Gómez Del Moral Martín-Consuegra, Manuel María; Martínez Naves, Eduardo
    Lenalidomide is an analog of thalidomide, with potent anticancer activity demonstrated in several hematological malignancies. It has immunomodulatory properties, being able to enhance the activation of different types of immune cells, which results in antitumor activities. Dendritic cells (DCs) are pivotal in the immune response, and different immunotherapeutic approaches targeting these cells are being developed. Since little is known about the effect of lenalidomide on DCs, the goal of the present work was to investigate the phenotype and function of human monocyte-derived DCs differentiated in the presence of lenalidomide (L-DCs). Our results showed that L-DCs display a unique phenotype, with increased cell surface expression of some maturation markers such as CD1d, CD83, CD86, and HLA-DR. This phenotype correlates with a lower expression of the E3 ubiquitin-ligase MARCH-I in L-DCs, upregulating the cell surface expression of CD86 and HLA-DR. In addition, immature L-DCs express higher amounts of DC-SIGN on the cell surface than control immature DCs. After LPS stimulation, production of IL-6 and TNF-α was severely decreased, whereas IL-12 and IL-10 secretion was dramatically upregulated in L-DCs, compared to that in the controls. Functionally, L-DCs are more effectively recognized by NKT cells in cytotoxicity experiments. Furthermore, L-DCs display higher opsonin-independent antigen uptake capability than control DCs. Mixed lymphocyte reaction experiments showed that L-DCs could stimulate naïve CD4 T-cells, polarizing them toward a predominant Th1 phenotype. In summary, DCs derived from monocytes in the presence of lenalidomide present a semi-mature phenotype, increased phagocytic capacity, reduced production of proinflammatory cytokines, and the ability to polarize T-cells toward predominant Th1-type responses; these are qualities that might be useful in the development of new immunotherapeutic treatments.
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    Project number: 252
    Competición de pósters científico/divulgativo como experiencia de inmersión al aprendizaje activo e integral por parte del alumnado de Ciencias de la Salud
    (2018) Redondo-Muñoz, Javier; Regueiro González-Barros, José Ramón; Monroy Muñoz, Francisco; Gómez del Moral Martín-Consuegra, Manuel María; Marín Marín, Ana Victoria; Medrano García, Sandra; Juárez Martín-Delgado, Ignacio; Briones Contreras, Alejandro; Martín Adrados, Beatriz; Lafuente Duarte, María Esther; Recio Hoyas, María José; Castro Sánchez, Patricia; Cárdenas Mastracusa, Paula; Martínez Quiles, Narcisa; Sánchez-Mateos Rubio, María Paloma
    Se implementará una actividad de desarrollo en grupos de alumnos de pósters científicos y divulgativos. Dicho aprendizaje facilitará la adquisición de competencias personales e interpersonales por parte del alumnado y fomentar futuras interacciones internacionales.