Person:
Collado Yurrita, Luis Rodolfo

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First Name
Luis Rodolfo
Last Name
Collado Yurrita
URI
https://hdl.handle.net/20.500.14352/79399
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Medicina
Area
Medicina
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2018 - 20194
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Author: San Mauro Martín, Ismael ×

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Now showing 1 - 4 of 4
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    Project number: 243
    Proyecto EVALUCA para el Fomento de la evaluacion de los sistemas de Calidad Universitarios
    (2018) Collado Yurrita, Luis Rodolfo; Ciudad Cabañas, María José; Benito León, Julián; Hernández Gallego, Jesús; Gómez-Lus Centelles, María Luisa; Alou Cervera, Luis; Sevillano Fernández, David; Cuadrado Cenzual, María Ángeles; Roiz Sastron, María del Carmen; Verdejo Bravo, Carlos; Madrigal Martínez-Pereda, Cristina María; O´Connor de la Oliva, Ana; Llama Palacios, María Arantxazu; Sánchez Beltrán, María Del Carmen; Menchén Viso, Luis Alberto; Baca González, Laura; Serrano Sánchez, Victor; Vaello Checa, Iris; Marín Viecho, Julia; Córdoba Manzanares, María de los Ángeles; Conty de la Campa, Raquel; Ribeiro Vidal, Honorato José; San Mauro Martín, Ismael
    El Proyecto Evaluca (Evaluación de la Calidad) tiene como objetivo el desarrollo de herramientas que contribuyan al Fomento de la participacion de la Comunidad Universitaria (PDI, PAS, Estudiantes y Egresados) en la evaluación de la calidad.
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    Gene Influence in the Effectiveness of Plant Sterols Treatment in Children: Pilot Interventional Study
    (Nutrients, 2019) San Mauro Martín, Ismael; Garicano Vilar, Elena; Sanz Rojo, Sara; Collado Yurrita, Luis Rodolfo; Pérez Arruche, Eva; Arce Delgado, Esperanza; Blumenfeld Olivares, Javier Andrés
    Cardiovascular disease is linked to high serum low density lipoprotein (LDL)-cholesterol levels. Cardiovascular risk may be indirectly influenced by genetic load. Serum LDL-cholesterol levels may be reduced by the consumption of food enriched with plant sterols (PS). The aim was to test a plant sterol treatment on cholesterol levels according to different genetic polymorphisms. A pilot interventional trial was performed in 26 children (n = 16 girls, n = 10 boys). Seven hundred milliliters/day of commercial skimmed milk with added plant sterols delivering 2.2 g plant sterols were ingested for three weeks. Blood draws were performed at the baseline and end of the study. Significant modifications of non-high density lipoprotein (HDL)-cholesterol (p = 0.010; p = 0.013) and LDL-cholesterol (p = 0.004; p = 0.013) levels appeared in the genes LIPC C-514T and PPAR-α L162V carriers. No statistically significant differences were observed for other genes. LIPC C-514T and PPAR-alpha L162V carriers could benefit from a plant sterol supplement to ameliorate hypercholesterolemia.
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    Project number: 204
    Curso de formación de profesorado en estructura departamental
    (2019) Collado Yurrita, Luis Rodolfo; Ciudad Cabañas, María José; Hernández Gallego, Jesús; Gómez-Lus Centelles, María Luisa; Tejedor Jorge, Alberto; Madrigal Martínez-Pereda, Cristina María; Alou Cervera, Luis; Sevillano Fernández, David; Benito León, Julián; Cuenca Caraballo, Maigualida; García Chacón, Marta; O´Connor de la Oliva, Anna; Marín Cuenda, María José; Roiz Sastrón, María del Carmen; San Mauro Martín, Ismael; Marín Viecho, Julia; Muñoz Lucas, María Angeles; Nieto Barbero, María Asunción; Callol Sánchez, Luis Miguel; Sanz Esporrín, Javier; García Torrent, María Jesús; Cuadrado Cenzual, María Ángeles
    El Proyecto propuesto es un Programa Formacion del Profesorado en Dirección y Gestión de Departamentos Universitarios dirigido al PDI, con apoyo del PAS, con la finalidad de obtener un cierto grado de profesionalización en Dirección Departamental.
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    Genomic Influence in the Prevention of Cardiovascular Diseases with a Sterol-Based Treatment
    (Diseases, 2018) San Mauro Martín, Ismael; Blumenfeld Olivares, Javier; Pérez Arruche, Eva; Arce Delgado, Esperanza; Ciudad Cabañas, María José; Garicano Vilar, Elena; Collado Yurrita, Luis Rodolfo
    Raised serum cholesterol concentration is a well-established risk factor in cardiovascular disease. In addition, genetic load may have an indirect influence on cardiovascular risk. Plant-based sterol-supplemented foods are recommended to help reduce the serum low-density lipoprotein cholesterol level. The objective was to analyse the influence of different polymorphisms in hypercholesterolemia patients following a dietary treatment with plant sterols. A randomised double-blind cross-over controlled clinical trial was carried out in 45 people (25 women). Commercial milk, containing 2.24 g of sterols, was ingested daily during a 3-week period, and then the same amount of skim milk, without sterols, was consumed daily during the 3-week placebo phase. Both phases were separated by a washout period of 2 weeks. At the beginning and end of each phase, blood draws were performed. Genes LIPC C-514T and APOA5 C56G are Ser19Trp carriers and greatly benefit from sterol intake in the diet. LIPC C-514T TT homozygous carriers had lower low-density lipoprotein cholesterol (LDL-c) levels than CC homozygote and CT heterozygote carriers after the ingestion of plant sterols (p = 0.001). These two genes also showed statistically significant changes in total cholesterol levels (p = 0.025; p = 0.005), and no significant changes in high-density lipoprotein (HDL) cholesterol levels (p = 0.032; p = 0.003), respectively. No statistically significant differences were observed for other genes. Further studies are needed to establish which genotype combinations would be the most protective against hypercholesterolemia.