Person:
Vivas Balcones, Luis David

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First Name
Luis David
Last Name
Vivas Balcones
URI
https://hdl.handle.net/20.500.14352/80857
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Medicina
Area
Medicina
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2008 - 200912010 - 20141
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Author: García Rubira, Juan Carlos × Subject: 616.379-008.64 ×

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    Efecto del tratamiento optimizado con insulina en la reactividad plaquetaria tras el alta de pacientes hiperglucémicos con síndrome coronario agudo
    (Revista Española de Cardiología, 2014) Vivas Balcones, Luis David; García Rubira, Juan Carlos; Bernardo, Esther; Angiolillo, Dominick J; Martín, Patricia; Calle Pascual, Alfonso Luis; Núñez Gil, Iván; Macaya Miguel, Carlos; Fernández Ortiz, Antonio
    Introduction and objectives: Intensive glucose control with insulin in patients with an acute coronary syndrome reduces platelet reactivity during hospitalization, compared to conventional control. However, the effect of strict, long-term glucose control on platelet reactivity in these patients remains uncertain. Methods: This is a prospective, randomized trial evaluating the effects of optimized glucose control (target glucose, 80-120mg/dL) with insulin, compared with conventional control (target glucose, <180 mg/dL), on platelet reactivity after hospital discharge in patients with an acute coronary syndrome and hyperglycemia. The primary endpoint was assessment of platelet aggregation after stimulation with adenosine diphosphate 20 μM at 12-month follow-up. Results: One hundred four patients were randomized to optimized management (n=53) or conventional management (n=51). There were no differences between groups in baseline characteristics or platelet function. After 12 months of follow-up, blood glucose levels were significantly lower in the optimized treatment group (104 vs 119 mg/dL; P<.001). However, platelet aggregation following adenosine diphosphate 20 μM stimulation showed no differences between the groups (54.2% [14.3%] vs 55.1% [18.3%] respectively; P=.81). There were no significant differences for other platelet function tests. Conclusions: Long-term optimized glucose control with insulin in patients with an acute coronary syndrome did not result in a reduction in platelet reactivity compared to conventional control.
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    Prognostic value of first fasting glucose measurement compared with admission glucose level in patients with acute coronary syndrome
    (Revista Española de Cardiología, 2008) Vivas Balcones, Luis David; García Rubira, Juan Carlos; González Ferrer, Juan José; Núñez Gil, Ivan Javier; Del Prado, Nayade; Fernández Ortiz, Antonio; Macaya, Carlos
    Estudio observacional unicéntrico que analizó 547 pacientes consecutivos ingresados por un síndrome coronario agudo. Se evaluaron los niveles de glucemia en varios puntos como fueron durante el ingreso y la primera glucemia en ayunas. El estudio concluyó que es la primera glucemia en ayunas y no al ingreso el parámetro que se relaciona con un factor de riesgo independiente de eventos cardiovasculares (muerte o reinfarto) durante la hospitalización.