Corticospinal upper motor neurons, methods and compositions for differentiating neural stem cells by modulating CB1 cannabinoid receptor signaling and use thereof
| dc.contributor.author | Galve Roperh, Ismael | |
| dc.contributor.author | Guzmán Pastor, Manuel | |
| dc.contributor.author | Díaz Alonso, Javier | |
| dc.contributor.author | Aguado Sánchez, Tania | |
| dc.contributor.patent | Universidad Complutense de Madrid | |
| dc.contributor.patent | Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas | |
| dc.date.accessioned | 2023-12-21T16:55:46Z | |
| dc.date.available | 2023-12-21T16:55:46Z | |
| dc.date.issued | 2012 | |
| dc.description | Representante: ABG Patentes, S.L. | |
| dc.description.abstract | The present invention relates to compositions and methods for obtaining a corticospinal upper motor neuron from a neural stem cell comprising the use of a CB1 cannabinoid receptor agonist, or the use of an inhibitor of an endocannabinoid-degrading enzyme, or the modification of a neural stem cell to decrease the expression of an endocannabinoid-degrading enzyme under basal levels or to increase the expression of the CB1 cannabinoid receptor above basal levels. The invention also relates to the corticospinal upper motor neurons obtained and uses thereof. | |
| dc.description.department | Depto. de Bioquímica y Biología Molecular | |
| dc.description.faculty | Fac. de Ciencias Biológicas | |
| dc.description.status | pub | |
| dc.identifier.officialurl | https://patents.google.com/patent/EP2733205A1/en | |
| dc.identifier.patent | EP2733205A1 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14352/91733 | |
| dc.language.iso | eng | |
| dc.page.total | 43 | |
| dc.rights.accessRights | open access | |
| dc.subject.cdu | 616.8 | |
| dc.subject.cdu | 577.1 | |
| dc.subject.ucm | Bioquímica (Biología) | |
| dc.subject.ucm | Neurociencias (Biológicas) | |
| dc.subject.unesco | 2490 Neurociencias | |
| dc.subject.unesco | 2403 Bioquímica | |
| dc.title | Corticospinal upper motor neurons, methods and compositions for differentiating neural stem cells by modulating CB1 cannabinoid receptor signaling and use thereof | |
| dc.title.alternative | Obere Pyramidenmotoneuronen, Verfahren und Zusammensetzungen zur Unterscheidung neuraler Stammzellen durch Modulation der CB1-Cannabinoidrezeptor-Signalisierung und Verwendungen davon | |
| dc.title.alternative | Neurones moteurs supérieurs cortico-spinaux, procédés et compositions permettant de différencier des cellules souches neurales par modulation de la signalisation des récepteurs cannabinoïdes CB1 et leurs utilisations | |
| dc.type | patent | |
| dc.type.hasVersion | VoR | |
| dspace.entity.type | Publication | |
| relation.isAuthorOfPublication | 8c2a1d13-f2a3-4355-8b66-73e0f97c0cea | |
| relation.isAuthorOfPublication | db8f53b8-3d54-4c2f-a483-c307151c09df | |
| relation.isAuthorOfPublication | bde4a39d-9dc8-42b0-9f07-fb332f13c2d6 | |
| relation.isAuthorOfPublication.latestForDiscovery | bde4a39d-9dc8-42b0-9f07-fb332f13c2d6 |
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