Person:
Martínez Rodrigo, Abel

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First Name
Abel
Last Name
Martínez Rodrigo
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Sanidad Animal
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2019 - 201912020 - 20223
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Now showing 1 - 4 of 4
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    Jornadas sobre la carrera investigadora: Módulo I, primera sesión: Etapas de la carrera Investigadora (predoctoral y postdoctoral).
    (2020-01-14) Martínez Rodrigo, Abel; Salazar Roa, María; Valdés Mora, Fátima; García Linares, Sara; Arias Álvarez, María; Briones Dieste, Víctor; San Andrés Moya, Margarita; Varela Nieto, Isabel; Serres Dalmau, Consuelo; Gascón Inchausti, Fernando
    La Facultad de Veterinaria y la Sociedad Española de Bioquímica y Biología Molecular (SEBBM) organizan de manera conjunta unas I Jornadas sobre la carrera investigadora que comenzarán en Enero de 2021. En la organización se ha colaborado de manera conjunta con otras Facultades de la UCM con similitud en sus programas de doctorado como son la Facultad de CC. Biológicas, la Facultad de CC. Químicas, la Facultad de Medicina y la Facultad de Farmacia. Las jornadas están encuadradas dentro de las Actividades Formativas de la Escuela de Doctorado de la UCM y están orientadas principalmente a Estudiantes de Doctorado, pero también a Investigadores en distintas etapas de su carrera investigadora, en el área de Ciencias de la Salud y Experimentales principalmente. Asimismo, hay sesiones que pueden resultar de interés para otras disciplinas debido a su carácter transversal.
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    Diseño y evaluación de estrategias vacunales frente a la leishmaniosis visceral y cutánea: optimización del candidato poliantigénico HisAK70
    (Universidad Complutense de Madrid, 2021-04-14) Martínez Rodrigo, Abel; Domínguez Bernal, Gustavo Ramón; Carrión Herrero, Francisco Javier
    La leishmaniosis es una enfermedad parasitaria causada por diferentes especies de protozoos incluidos en el género Leishmania. Está catalogada como una enfermedad tropical desatendida, presentándose en distintas regiones de la Cuenca Mediterránea y Oriente Medio, así como en países que se encuentran en áreas tropicales y subtropicales. En los seres humanos existen diferentes cuadros clínicos, dependiendo de la especie de Leishmania implicada. Su sintomatología varía desde la aparición de lesiones locales, leishmaniosis cutánea (CL) y mucocutánea (MCL), hasta la afectación sistémica, leishmaniosis visceral (VL), e incluso la muerte del paciente en ausencia de un tratamiento adecuado. Cabe destacar que el perro es el principal reservorio de L. infantum, organismo causante de la VL zoonótica humana, lo que lo convierte en un importante agente epidemiológico...
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    Transcriptomic Profile of Canine DH82 Macrophages Infected by Leishmania infantum Promastigotes with Different Virulence Behavior
    (MPDI, 2022-01-27) Mas, Alicia; Martínez Rodrigo, Abel; Carrión, Javier; Orden, José Antonio; Alzate, Juan F.; Domínguez Bernal, Gustavo Ramón; Horcajo, Pilar
    Zoonotic visceral leishmaniosis caused by Leishmania infantum is an endemic disease in the Mediterranean Basin affecting mainly humans and dogs, the main reservoir. The leishmaniosis outbreak declared in the Community of Madrid (Spain) led to a significant increase in human disease incidence without enhancing canine leishmaniosis prevalence, suggesting a better adaptation of the outbreak’s isolates by other host species. One of the isolates obtained in the focus, IPER/ES/2012/BOS1FL1 (BOS1FL1), has previously demonstrated a different phenotype than the reference strain MCAN/ES/1996/BCN150 (BCN150), characterized by a lower infectivity when interacting with canine macrophages. Nevertheless, not enough changes in the cell defensive response were found to support their different behavior. Thus, we decided to investigate the molecular mechanisms involved in the interaction of both parasites with DH82 canine macrophages by studying their transcriptomic profiles developed after infection using RNA sequencing. The results showed a common regulation induced by both parasites in the phosphoinositide-3-kinase–protein kinase B/Akt and NOD-like receptor signaling pathways. However, other pathways, such as phagocytosis and signal transduction, including tumor necrosis factor, mitogen-activated kinases and nuclear factor-κB, were only regulated after infection with BOS1FL1. These differences could contribute to the reduced infection ability of the outbreak isolates in canine cells. Our results open a new avenue to investigate the true role of adaptation of L. infantum isolates in their interaction with their different hosts.
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    Immunization with the HisAK70 DNA Vaccine Induces Resistance against Leishmania Amazonensis Infection in BALB/c Mice
    (MDPI, 2019-11-14) Martínez Rodrigo, Abel; S. Dias, Daniel; Ribeiro, Patrícia A. F.; Roatt, Bruno M.; Mas Zubiri, Alicia; Carrión Herrero, Francisco Javier; Coelho, Eduardo A. F.; Domínguez Bernal, Gustavo Ramón
    Leishmania amazonensis is the aetiological agent of a broad spectrum of leishmaniosis in South America. It can cause not only numerous cases of cutaneous leishmaniosis but also diffuse cutaneous leishmaniosis. Considering the diversity of parasite species causing different forms of the disease that coexist in the same region, it is desirable to develop a vaccine capable of eliciting cross-protection. We have previously described the use of HisAK70 DNA vaccine for immunization of mice to assess the induction of a resistant phenotype against Leishmania major and infantum infections. In this study, we extended its application in the murine model of infection by using L. amazonensis promastigotes. Our data revealed that 14 weeks post-infection, HisAK70-vaccinated mice showed key biomarkers of protection, such as higher iNOS/arginase activity, IFN-γ/IL-10, IFN-γ/IL-4, and GM-CSF/IL-10 ratios, in addition to an IgG2a-type response when compared to the control group. These findings correlated with the presentation of lower footpad swelling and parasite burdens in the immunized compared to the control mice. Overall, this study suggests that immunization with HisAK70 may be considered a suitable tool to combat leishmaniosis as it is able to induce a potent cellular immune response, which allows to control the infection caused by L. amazonensis.