Person:
Sanz Ruiz, Pablo

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First Name
Pablo
Last Name
Sanz Ruiz
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Cirugía
Area
Traumatología y Ortopedia
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2013 - 201912020 - 20221
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    Publication
    The tale of microencapsulated rifampicin: is it useful for the treatment of periprosthetic joint infection?
    (Springer, 2022-01-06) López Torres, Irene Isabel; Vaquero Martín, Javier; Torres Suárez, Ana Isabel; Navarro García, Federico; Fraguas Sánchez, Ana Isabel; León Román, Víctor Estuardo; Sanz Ruiz, Pablo
    Purpose Microencapsulation techniques have allowed the addition of rifampicin to bone cement, but its in vivo efficacy has not been proven. The aim of our study is to determine the superiority of cement containing gentamicin and rifampicin microcapsules in the treatment of PJI versus cement exclusively containing gentamicin. Methods An S. aureus PJI was induced in 15 NZW rabbits. A week after inoculation, the first stage of replacement was carried out, and the animals were divided into two groups: group R received a spacer containing gentamicin and rifampicin microcapsules, and group C received a spacer containing gentamicin. Intra-articular release curve of rifampicin and infection and toxicity markers were monitored for four weeks post-operatively, when microbiological analysis was performed. Results The microbiological cultures showed a significantly lower growth of S. aureus in soft tissue (2.3·104 vs 0; p = 0.01) and bone (5.7·102 vs 0; p = 0.03) in the group with rifampicin microcapsules. No differences were found in systemic toxicity markers. Rifampicin release from the cement spacer showed higher concentrations than the staphylococcal MIC throughout the analysis. Conclusion The in vivo analyses demonstrated the superiority of cement containing gentamicin and rifampicin microcapsules versus the isolated use of gentamicin in the treatment of PJI in the rabbit model without serious side effects due to the systemic absorption of rifampicin. Given the increasing incidence of staphylococci-related PJI, the development of new strategies for intra-articular administration of rifampicin for its treatment has a high clinical impact.
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    Publication
    Estudio experimental de la influencia de la adición de distintos antibióticos sobre las características mecánicas del cemento óseo (polimetil-metacrílato)
    (Universidad Complutense de Madrid, 2013-02-08) Sanz Ruiz, Pablo; Vaquero Martín, Javier; Forriol Campos, Francisco