Person:
Moreno Jiménez, Florencio

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First Name
Florencio
Last Name
Moreno Jiménez
URI
https://hdl.handle.net/20.500.14352/79918
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Óptica y Optometría
Department
Química Orgánica
Area
Química Orgánica
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End date: 2009 × Start date: 2000 ×

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Now showing 1 - 6 of 6
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    Enantiospecific synthesis of substituted 1-norbornanesulfonic acids and 1-norbornanesulfenic and sulfonic acid derivatives
    (Tetrahedron: Asymmetry, 2000) Garcı́a Martı́nez, Antonio; Teso Vilar, Enrique; Moreno Jiménez, Florencio; Garcı́a Amo, María
    New homochiral 1-norbornanesulfenic and sulfonic acid derivatives 2–7, as well as the sulfonic acids 8, are easily synthesised starting from 2-methylene-1-norbornylthiotriflates 1. This new class of homochiral bridgehead thiosulfonates was prepared by us from naturally occurring (+)-camphor and (−)-fenchone. Nucleophilic substitution at the sulfenyl sulfur atom is the key step for this synthetic strategy
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    Nuevas metodologías en la cociclación en síntesis de pirimidinas
    (2002) Moreno Jiménez, Florencio; García Martínez, Antonio; Herrera Fernández, Antonio
    En esta tesis doctoral se demuestra que el mecanismo de las cetonas enolizables con anhidrido trifluormetanosulfonico (tf2o) transcurre a través de la formación de un catión trifiiloxicarbenio como intermedio. A partir de este punto se abordan distintos aspectos mecanísticos de la reactividad de cetonas y aldehidos con tf2o en presencia de nitrilos. De forma paralela se desarrollan las aplicaciones sintéticas derivadas de esta reactividad, presentando nuevos métodos de síntesis de alquil y aril-pirimidinas, 2,4-diiodopirimidinas, isoureas, guanidinas y 2,4-bis(metiltio)-pirimidinas empleadas posteriormente para la obtención de 2,4-bis(metilsulfonil)pirimidinas, uracilos, 4-amino-2-metilsulfonil-pirimidinas y 2,4-diaminopirimidinas.
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    A novel and simple procedure for the enantiospecific synthesis of bridgehead norbornane thioethers and thiocyanates
    (Tetrahedron: Asymmetry, 2002) Garcı́a Martı́nez, Antonio; Teso Vilar, Enrique; Moreno Jiménez, Florencio; Álvarez García, Ana María; Pinilla Rodríguez, Patricia
    An easy three-step route for the enantiospecific synthesis of novel 1-norbornyl thioethers and thiocyanates from readily available natural fenchone and camphor is described. The key step of the synthetic route is the nucleophilic substitution over the sulfenyl sulfur atom of the intermediate thiotriflates by the corresponding C-nucleophiles.
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    A novel modification of the Ritter reaction: stereoselective synthesis of bridgehead-fused Δ2-norbornanethiazolines from thiocamphor and thiofenchone
    (Tetrahedron: Asymmetry, 2006) García Martínez, Antonio; Teso Vilar, Enrique; Moreno Jiménez, Florencio; Álvarez García, Ana María
    An easy two-step route for the stereoselective synthesis of novel bridgehead-fused norbornanethiazolines from readily available natural camphor and fenchone is described. The key step of the synthetic route is the highly stereoselective trapping of 1-(trifluoromethylsulfonylthio)-2-norbornyl cations by nitriles followed by intramolecular cyclization, which constitutes a new modification of the Ritter reaction
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    A short and convenient procedure for the stereoselective synthesis of 2-hydroxy-1-norbornanesulfonamides
    (Tetrahedron: Asymmetry, 2004) Garcı́a Martı́nez, Antonio; Teso Vilar, Enrique; Moreno Jiménez, Florencio; Álvarez Garcı́a, Ana Mª
    A short and convenient procedure for the stereoselective synthesis of novel optically active 2-hydroxy-1-norbornanesulfonamides starting from commercially available natural camphor and fenchone is reported. The synthetic route involves a nucleophilic substitution at the sulfenyl sulfur atom of 2-methylene-1-norbornylthiotriflates followed by oxidation of the intermediate sulfenamides and highly diastereoselective reduction of the carbonyl group of the parent 2-oxo-1-norbornanesulfonamides.
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    Determination of the oxygen permeability (Dk) of contact lenses with a fiber-optic luminescent sensor system
    (Sensors and Actuators B - Chemical, 2007) Pérez Ortíz, Noelia; Navarro Villoslada, Fernando; Orellana Moraleda, Guillermo; Moreno Jiménez, Florencio
    An optical sensing system, alternative to current electrochemical techniques, has been developed for determining the oxygen permeability (Dk) of rigid gas-permeable contact lenses. The novel sensor is based on kinetic measurements of the oxygen partial pressure inside a chamber sealed by the sample contact lens, where a thin luminescent O2-sensitive film is placed. The standard equation for calculating the Dk value of the lens material has been adapted to the optical technique and a fitting procedure of the sensor response has been developed to achieve the maximum accuracy and precision. Unlike the electrochemical techniques, the optical sensor is unaffected by the contact lens thickness and the lens edge and boundary effects. Therefore, the latter does not require lengthy measuring procedures for extracting the actual Dk values. The optical sensor system has been applied to oxygen permeability determinations of commercial contact lenses of nominal Dk values equal to 17 and 36 ANSI units of 10−11 cm3 cm/s cm2 mmHg.