Person:
Madrid Albarrán, María Yolanda

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First Name
María Yolanda
Last Name
Madrid Albarrán
URI
https://hdl.handle.net/20.500.14352/76072
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Analítica
Area
Química Analítica
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Start date: 2017 × Subject: 544 ×

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    (Bio)analytical approaches for investigating the role of selenium in preventing neurological disorders and neurotoxicity induced by environmental neurotoxicants: As, Cd, and Hg
    (Trends in Analytical Chemistry, 2024) Gómez Gómez, Beatriz; Fernández Bautista, Tamara; Madrid Albarrán, María Yolanda
    There is increasing evidence that dysfunction of essential metal (Cu, Zn, Fe, Mn) homeostasis can lead to the appearance of several NDs. Other neurotoxic environmental metal/metalloids such as As, Cd and Hg contribute to neurological diseases by interacting with neurotransmitter receptors and protein binding sites of essential elements. Analytical chemists do not remain indifferent to the impact of neurological diseases. The development of analytical techniques to evaluate the role of endogenous and exogenous metals metals/metalloids in the development of neurogenerative diseases has increased in the last few years. This review summarizes the state of the art of the (bio)analytical techniques most applied together with in vitro models to evaluate the role of elements associated with neurological disorders with special emphasis on the role of selenium in neurodegeneration and in preventing the neurotoxic effects produced by environmental neurotoxins, in particular Cd, Hg and As.