Person: Sanz Esporrín, Javier
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First Name
Javier
Last Name
Sanz Esporrín
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Odontología
Department
Especialidades Clínicas Odontológicas
Area
Estomatología
Identifiers
5 results
Search Results
Now showing 1 - 5 of 5
Item Cell Therapy Based on Gingiva-Derived Mesenchymal Stem Cells Seeded in a Xenogeneic Collagen Matrix for Root Coverage of RT1 Gingival Lesions: An In Vivo Experimental Study(International Journal of Molecular Sciences, 2022) Sanchez, Nerea; Vignoletti, Fabio; Sanz Martín, Ignacio; Coca, Alejandro; Núñez, Javier; Maldonado Bautista, Estela; Sanz Esporrín, Javier; Hernando Pradíes, Irene; Santamaría, Silvia; Herrera González, David; Garcia Sanz, Jose A.; Sanz Alonso, Mariano(1) Background: To investigate the effect of a xenogeneic collagen matrix (CMX) seeded with autologous gingiva-derived mesenchymal cells (GMSCs) when combined with a coronally advanced flap (CAF) in the treatment of localized gingival recession type 1 (RT1). (2) Methods: Dehiscence-type defects were created in seven dogs. GMSCs were isolated, transfected with a vector carrying green fluorescent protein (GFP) and expanded. Once chronified, the defects were randomly treated with (1) CAF plus the combination of CMX and GFP+ GMSCs, (2) CAF plus CMX with autologous fibroblasts, (3) CAF plus CMX and (4) CAF alone. Histological and clinical outcomes at 2- and 6-week healing periods were analyzed and compared among groups. (3) Results: Histologically, the addition of autologous cells to the CMX resulted in reduced inflammation and a variable degree of new cementum/bone formation. CMX plus GMSCs resulted in greater mean recession reduction (1.42; SD = 1.88 mm) and percentage of teeth with recession reduction of ≥2 mm (57%) when compared to the other groups, although these differences were not statistically significant. (4) Conclusions: The histometric and clinical results indicated a positive trend favouring the combination of CMX and GMSCs with the CAF when compared to the groups without cells, although these differences were not statistically significant.Item In vitro effect of different implant decontamination methods in three intraosseous defect configurations(Clinical Oral Implants Research, 2022) Luengo Mas, Fernando; Sanz Esporrín, Javier; Noguerol, Fernando; Sanz Martín, Ignacio; Sanz Sánchez, Ignacio; Sanz Alonso, MarianoObjectives This in vitro investigation was aimed to evaluate the cleaning ability of four mechanical devices designed for decontaminating implant surfaces. Material and methods Ninety-six implants were coated with permanent ink and inserted into 3D-printed resin blocks simulating three different intraosseous defect configurations (types Ib, Ic, and Ie). The four tested mechanical decontamination devices (air-polishing with glycine powder, rotating titanium brush, polyetheretherketone [PEEK]-coated ultrasonic tip, and stainless steel ultrasonic tip) were randomly applied onto the 5 mm exposed implant surface. Standardized photographs were taken from a frontal perspective and with a 30° angle coronally and apically to the implant axis. The area with remnant ink on the implant surface was calculated. Results Although none of the groups achieved complete ink removal, air-polishing with glycine and titanium brushes demonstrated a higher cleaning ability when compared with ultrasonic devices either with standard or PEEK tips for all three defect configurations. For the three tested models, the best cleaning ability in all groups was shown on implant surfaces without facing an intraosseous wall. Titanium brush was the most effective when the intraosseous walls existed. Cleaning effectiveness diminished in the threads located in the apical third, especially when using air-polishing and ultrasonic devices. Conclusions Titanium brushes and air-polishing devices were more effective in removing artificial biofilm using this in vitro model, although their effectiveness was influenced by the presence of the intrabony component.Item Immunohistochemical, histomorphometric, and gingival crevicular fluid analysis of residual and shallow periodontal pockets in patients with periodontitis Stages III and IV(Journal of Periodontology, 2019) Martínez Villa, Sergio; Sanz Martín, Ignacio; Maldonado Bautista, Estela; Virto Ruiz, Leire; Sanz Esporrín, Javier; Sanz Alonso, MarianoBackground: To study the differences between shallow and residual periodontal pockets in patients with periodontitis (Stages III and IV) after non-surgical periodontal treatment. Methods: Twenty patients diagnosed of periodontitis who were scheduled for periodontal surgery were included. In each patient, a palatal shallow site (≤3 mm) and a residual site (≥5 mm) were selected and GCF samples were processed by Luminex® analysis to determine the concentrations of interleukins (IL-1β, IL-6, IL-10, and IL-17a). During the periodontal surgery gingival biopsies were collected and processed for histo-morphometric and immunohistochemical evaluation to determine the extent of connective tissue inflammatory infiltrate (CTII) using the following markers (CD4, CD5, CD8, CD14, CD19, Elastase, and Syndecan). Mean differences between shallow and residual pockets samples, as well as correlations between GCF cytokine concentrations, area of CTII, and cellularity of the CTII were calculated. Results: A total of 15 patients were finally included, with analysis of 30 histological specimens and 30 GCF samples. Residual pockets presented significantly higher mean GCF volume, higher mean area of CTII and higher concentrations of IL-1β and IL-6 in GCF than shallow pockets. A significant correlation was detected between IL-10 levels and the CTII area, IL-10 and the percentage of Syndecan, and the area of CTII and the percentages of CD14 and Syndecan. Conclusions: The concentration of GCF cytokines did not correlate with the area of CTII measured histologically. A residual CTII and elevated concentrations of proinflammatory cytokines and cells were present in all sites 2 months after non-surgical treatment. The lack of healthy controls does not allow to establish differences between both groups.Item Periimplantitis experimental en implantes con conexión implante/pilar con cambio de plataforma(2014) Sanz Esporrín, Javier; Sanz Alonso, Mariano; Sanz Casado, José V.- Project number: 204
Item Curso de formación de profesorado en estructura departamental(2019) Collado Yurrita, Luis Rodolfo; Ciudad Cabañas, María José; Hernández Gallego, Jesús; Gomez-Lus Centelles, Maria Luisa; Tejedor Jorge, Alberto; Madrigal Martínez-Pereda, Cristina María; Alou Cervera, Luis; Sevillano Fernández, David; Benito León, Julián; Cuenca Caraballo, Maigualida; García Chacón, Marta; Oconnor de la Oliva, Anna; Marín Cuenda, María José; Roiz Sastrón, María del Carmen; San Mauro Martín, Ismael; Marín Viecho, Julia; Muñoz Lucas, María Angeles; Nieto Barbero, Maria Asunción; Callol Sánchez, Luis Miguel; Sanz Esporrín, Javier; García Torrent, María Jesús; Cuadrado Cenzual, María ÁngelesEl Proyecto propuesto es un Programa Formacion del Profesorado en Dirección y Gestión de Departamentos Universitarios dirigido al PDI, con apoyo del PAS, con la finalidad de obtener un cierto grado de profesionalización en Dirección Departamental.