Person: Hernández Verdejo, José Luis
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First Name
José Luis
Last Name
Hernández Verdejo
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Óptica y Optometría
Department
Optometría y Visión
Area
Optica
Identifiers
41 results
Search Results
Now showing 1 - 10 of 41
Item Evaluation of the Ultrastructural and In Vitro Flow Properties of the PRESERFLO MicroShunt(Translational vision science & technology, 2021) Ibarz Barberá, Marta; Hernández Verdejo, José Luis; Bragard, Jean; Burguete, Javier; Morales Fernández, Laura; Tañá Rivero, Pedro; Gómez de Liaño, Rosario; Teus Guezala, Miguel ÁngelPurpose: To measure the in vitro flow properties of the PRESERFLO implant for comparison with the theoretical resistance to flow. Methods: The PRESERFLO was designed to control the flow of aqueous humor according to the Hagen-Poiseuille (HP) equation. Scanning electron microscopy (SEM) was performed to analyze the ultrastructure, and flowmeasurementswere carried out using a gravity-flow setup. Results: SEM images of the PRESERFLO showed luminal diameters of 67.73 × 65.95 μm and 63.66 × 70.54 μm. The total diameter was 337.2 μm, and the wall was 154 μm wide. The theoretical calculation of the resistance to flow(R) for an aqueous humor (AH) viscosity of 0.7185 centipoises (cP) was 1.3 mm Hg/(μL/min). Hence, assuming a constant AH flow of 2 μL/min, the pressure differential across the device (�P) was estimated to be 2.6 mm Hg. The gravity-flow experiment allowed us to measure the experimental resistance to flow, which was RE =1.301mmHg/(μL/min), in agreement with the theoretical resistance to flow R given by the HP equation. Conclusions: The experimental and theoretical flow testing showed that the pressure drop across this device would not be large enough to avoid hypotony unless the resistance to outflowof the sub-Tenon space was sufficient to control the intraocular pressure in the early postoperative period. Translational Relevance: The fluid properties of glaucoma subconjunctival drainage devices determine their specific bleb-forming capacity and ability to avoid hypotony and therefore their safety and efficacy profile.Item The role of clinical diagnosis criteria on the frequency of accommodative insufficiency(International journal of ophthalmology, 2019) García Montero, María; Antona Peñalba, Beatriz; Barrio de Santos, Ana Rosa; Nieto Zayas, Carmen; Martínez Alberquilla, Irene; Hernández Verdejo, José LuisAIM: To estimate and compare the frequency of accommodative insufficiency (AI) within the same clinical population sample depending on the type of clinical criteria used for diagnosis. Comparing the frequency within the same population would help to minimize bias due to sampling or methodological variability. METHODS: Retrospective study of 205 medical records of symptomatic subjects free of any organic cause and symptoms persisting despite optical compensation evaluated. Based on the most commonly clinical diagnostics criteria found in the literature, four diagnostics criteria were established for AI (I, II, III and IV) based on subjective accommodative tests: monocular accommodative amplitude two or more diopters below Hofstetter’s minimum value [15-(0.25×age)] (I, II, III, IV); failing monocular accommodative facility with minus lens, establishing the cut-off in 0 cycles per minute (cpm) (I) and in 6 cpm (II, III); failing binocular accommodative facility with minus lens, establishing the cut-off in 0 cpm (I) and in 3 cpm (II). RESULTS: The proportion of AI (95%CI) for criteria I, II, III and IV were 1.95% (0.04%-3.86%), 2.93% (0.31%-4.57%), 6.34% (1.90%-7.85%) and 41.95% (35.14%-48.76%) respectively, with a statistically significant difference shown between these values (χ2=226.7, P<0.001). A pairwise multiple comparison revealed that the proportion of AI detected for criterion IV was significantly greater than the proportion for the rest of the criteria (P-adjusted<0.05 in all cases). CONCLUSION: The prevalence of cases of AI within the same clinical population varies with the clinical diagnostic criteria selected. The variation is statistically significant when considering the monocular accommodative amplitude as the only clinical diagnostic sign.Item Historia y prehistoria de los optotipos: de Alcor y Mizar al optotipo ETDRS(Archivos de la Sociedad Española de Oftalmología, 2016) González Martín-Moro, Julio; Hernández Verdejo, José Luis; Azurza Rivas, G.Item Long-Term Impacts of Orthokeratology Treatment on Sub-Basal Nerve Plexus and Corneal Sensitivity Responses and Their Reversibility(Eye & Contact Lens: Science & Clinical Practice, 2017) Nombela Palomo, María; Felipe Márquez, Gema; Teus, Miguel Ángel; Hernández Verdejo, José Luis; Nieto Bona, AmeliaPurpose: To examine the effects of one year of overnight orthokeratology (OK) treatment on the sub-basal nerve plexus (SBNP) and corneal sensitivity and to assess the reversibility of these effects one month after treatment interruption. Methods: Thirty-two subjects with low-moderate myopia underwent OK treatment for one year. Fifteen non-contact lens wearers served as controls. At the time points baseline, one year of treatment, and one month after removing the OK lenses, two tests were conducted: corneal sensitivity (Cochet-Bonnet esthesiometer) and SBNP imaging by in vivo confocal microscopy. Results: In participants wearing OK lenses, significant reductions over the year were produced in SBNP nerve density (P=0.001 and P=0.006) and number of nerves (P<0.001 and P=0.001) in the central and mid-peripheral cornea, respectively. Differences over the year were also detected in central objective tortuosity (P=0.002). After lens removal, baseline values of nerve density (P=0.024 and P=0.001) and number of nerves (P=0.021 and P<0.001) for the central and mid-peripheral cornea, respectively, were not recovered. At one month post-treatment, a difference was observed from one-year values in central corneal sensitivity (P=0.045) and mid-peripheral Langerhans cell density (P=0.033), and from baseline in mid-peripheral objective tortuosity (P=0.049). Direct correlation was detected at one year between nerve density and tortuosity both in the central (P<0.01; r=0.69) and mid-peripheral cornea (P<0.01; r=0.76). Conclusions: Long-term OK treatment led to reduced SBNP nerve density and this was directly correlated with corneal tortuosity. After one month of treatment interruption, nerve density was still reduced.Item Changes in the Choroidal Thickness of Children Wearing MiSight to Control Myopia(Journal of Clinical Medicine, 2022) Prieto Garrido, Francisco Luis; Villa Collar, César; Hernández Verdejo, José Luis; Álvarez Peregrina, Cristina; Ruiz Pomeda, AliciaBackground: Due to the importance of choroidal thickness in the development of myopia, this study examined the effect of MiSight contact lenses (CLs) on the choroidal thickness of myopic children and the differences between responders and non-responders to the treatment with these CLs. Methods: A total of 41 myopic children were fitted with MiSight CLs and 33 with single-vision spectacles. They were followed up for two years. Subfoveal choroidal thickness and choroidal thickness 1 and 3 mm temporal and nasal to the fovea were measured by OCT at baseline and one and two years after the treatment. Differences in all the choroidal thickness parameters were assessed in each group over time. Patients from the MiSight group were classified based on a specific range of changes in axial length at the end of the second year of treatment as “responders” (AL change < 0.22 mm/per year) and “non-responders”, and the choroidal thickness of both groups was analyzed. Results: The subfoveal choroidal thickness of the MiSight and single-vision spectacle groups did not show any changes over time. Wearing MiSight CLs induced relative choroidal thickening in the responder group in the first year of treatment. Conclusion: Choroidal thickness might work as a predictor of the effectiveness of MiSight in myopia treatment.Item Randomized crossover trial of silicone hydrogel contact lenses(Contact Lens and Anterior Eye, 2018) García Montero, María; Rico del Viejo, Laura; Llorens Quintana, Clara; Lorente Velázquez, Amalia; Hernández Verdejo, José Luis; Madrid Costa, DavidPurpose: The aim of the current study is to assess, using new technologies, the interaction of four monthly silicone hydrogel contact lenses on the ocular surface and the comfort over 15 days of use. Methods: Prospective cross-over, randomized and double-masked study including four materials (lotrafilcon-B, samfilcon-A , comfilcon-A and filcom-V3). Clinical examination was performed in the following order: tear meniscus height, first break-up of the tear film, the average time of all tear film breakup incidents, bulbar redness, limbal redness (Keratograph 5M ,Oculus, Germany); central corneal thickness (Pentacam, Oculus, Germany), thermography values (FLIR A325; FLIR Systems Inc., USA), and slit-lamp evaluations, including ocular surface staining. Finally, subjective comfort was obtained from Contact Lens Dry Eye Questionnaire-8. Results: The impact of contact lens wear on the ocular surface didn’t show statistically significant changes over time except for corneal and conjunctival staining grades on day 15 compared to day 1 for the comfilcon A group (P = .003 and P = .01, respectively). Contact lens stability and impact on the ocular surface during contact lens wear didn’t show statistically significant changes over time except in the case of the comfilcon A material with respect to the irritation item (P = .01). Conclusions: These results suggest that the impact of monthly silicone hydrogel contact lens materials on the ocular surface after and during contact lens wear, contact lens stability over time, and subjective comfort did not reveal any significant changes over 15 days of use for any of the materials.Item Predicting factors for progression of the myopia in the MiSight assessment study Spain (MASS)(Journal of Optometry, 2021) Prieto Garrido, Francisco Luis; Hernández Verdejo, José Luis; Villa Collar, César; Ruiz Pomeda, AliciaPurpose: To investigate which baseline factors are predictive for success in controlling myopia progression in a group of children wearing MiSight Contact Lens (CLs). Methods: Myopic patients (n = 41) fitted with MiSight CLs and followed up two years were included in this study. Bivariate analysis, a logistic regression analysis (LG) and a decision tree (DT) approach were used to screen for the factors influencing the success of the treatment. To assess the response, axial length (AL) changes were considered as main variable. Patients were classified based on a specific range of change of axial length at the end of each year of treatment as ‘‘responders’’ (R) (AL change <0.11 mm/per year) and ‘‘non-responders’’ (NR) (AL change ≥0.11 mm/per year). Results: Of a total of forty-one Caucasian patients treated with MiSight CLs, 21 and 16 were considered responders in the first and the second year of follow-up, respectively. LG analysis showed that the only factor associated with smaller axial length growth was more time spent outdoors (p = 0.0079) in the first year of treatment. The decision tree analysis showed that in the responding group spending more than 3 and 4 h outdoors per week was associated with the best response in the first year and in the second year of treatment respectively. Conclusions: The LR and the DT approach of this pilot study identifies time spent outdoors as a main factor in controlling axial eye growth in children treated with MiSight CLs.Item Effects of Blink Rate on Tear Film Optical Quality Dynamics with Different Soft Contact Lenses(Journal of Ophthalmology, 2019) García Montero, María; Rico del Viejo, Laura; Martínez Alberquilla, Irene; Hernández Verdejo, José Luis; Lorente Velázquez, Amalia; Madrid Costa, DavidObjective. The aim of this study was to investigate tear film optical quality dynamics for four types of silicone hydrogel contact lenses (SHCLs) for daily wear over a 15-day period and for different blink rate (BR) patterns. Methods. A prospective randomized, double-blind, cross-over pilot study including four SHCLs (A: lotrafilcon B (Air Optix plus HydraGlyde, Alcon Laboratories); B: samfilcon A (Ultra, Bausch & Lomb); C: comfilcon A (Biofinity, CooperVision); and D: filcom V3 (Blu:gen, Mark’Ennovy)). Serial measurements of Objective Scatter Index (OSI) using the HD Analyzer (Visiometrics S.L., Terrassa, Spain) were taken at different blinking patterns: blinking every 2.5 seconds (high BRs) and every 9 seconds (low BRs). They were performed during the first visit before CL insertion (baseline), after 20 minutes of CL wear (Day 1), and during the last visit after 8 hours of CL wear on day 15 of use (Day 15). Results. Normal young healthy subjects were recruited and fitted with the four lenses. For low BRs, the mean OSI value increased over time for all CLs and the slope of the curve also increased for all CLs, except for CL D. However, for high BRs, the mean OSI value increased only for CLs B and C and the slope of the curve did not change over time for any of them. Conclusions. These results suggest that the tear film optical quality dynamics after wearing SCHLs for 15 days seems to undergo a slight deterioration only for lowest BR.Item Impact of femtosecond laser-assisted in situ keratomileusis on retinal ganglion cell function(European Journal of Ophthalmology, 2021) Lauzirika, Gorka; Arranz Márquez, Esther; García González, Montserrat; Hernández Verdejo, José Luis; Teus Guezala, Miguel ÁngelPurpose: To analyse the effect of femtosecond laser-assisted in situ keratomileusis (FS-LASIK) on the electrical response of retinal ganglion cells using pattern electroretinography (pERG). Methods: This was a longitudinal, prospective, observational pilot study. We included consecutive myopic patients who underwent FS-LASIK to correct up to 6dioptres of myopia and up to 2dioptres of astigmatism. Patients with excessive blinking or tearing and those with Snellen uncorrected visual acuity less than 0.9 dec on postop day 1 were excluded. Diopsys NOVA® (Diopsys Inc., NJ) pERG records, using high- and low-contrast patterns, were obtained 16 h and 1month after FS-LASIK was performed. Magnitude (μV), Magnitude D (μV), Magnitude D/Magnitude ratio and signal-to-noise ratio (dB) were analysed. Wilcoxon test for nonparametric paired data was employed. Results: pERG data from 24 eyes were analysed from 24 patients who underwent FS-LASIK. Mean age was 35.79±9.86 years. Mean preoperative refraction was −2.69±7.6D (spherical) and −0.38±0.40D (cylinder). Mean surgical time was 56.88±7.6s. No statistically significant differences were obtained for any of the studied parameters when comparing 16h with 1month after FS-LASIK, with the exception of Magnitude with low contrast, which increased from 1.21±0.2 to 1.39±0.29µV at 16 h and 1month postoperatively, respectively (p=0.03). Conclusions: FS-LASIK seems to induce a mild and transitory defect in retinal ganglion cell function. Only a mild decrease was detected in the magnitude value for low-contrast stimuli when pERG was performed 16h postoperatively, and it returned to normal 1 month after surgery.Item Impact of contact lens material and design on the ocular surface(Clinical and Experimental Optometry, 2017) Ruiz Alcocer, Javier; Monsálvez Romín, Daniel; García Lázaro, Santiago; Albarrán Diego, Cesar Antonio; Hernández Verdejo, José Luis; Madrid Costa, DavidBackground: To evaluate the impact on the ocular surface of a daily disposable hydrogel contact lens with high water content compared with two silicone hydrogel daily disposable lenses of lower water content. Methods: The hydrogel lens assessed was made from nesofilcon A and the silicone hydrogel lenses were made of delefilcon A and stenfilcon A. Contact lens thickness was measured to assess material stability during daily wear, and ocular surface parameters such as tear film osmolarity, tear meniscus area and central corneal thickness were also assessed. Optical quality was analysed for all cases by means of wavefront aberrometry. Results: The nesofilcon A was shown to be the thinnest lens (p<0.001), while no differences in lens thickness were found between the two silicone hydrogel lenses (p=0.495). No significant differences were found in tear film osmolarity, tear meniscus area, central corneal thickness or corneal aberrations, either as a function of the lens measured or time of use (p>0.05). Conclusion: In spite of having the thinnest lens and the highest water content, the hydrogel does not significantly impact on tear film and corneal swelling after one day of use in first-time wearers.