Person: Torres Simón, Lucía
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First Name
Lucía
Last Name
Torres Simón
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Psicología
Department
Psicología Experimental, Procesos Cognitivos y Logopedia
Area
Identifiers
5 results
Search Results
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Item Episodic memory dysfunction and hypersynchrony in brain functional networks in cognitively intact subjects and MCI: a study of 379 individuals(Geroscience, 2022) Chino, Brenda; Cuesta Prieto, Pablo; Pacios García, Javier; De Frutos Lucas, Jaisalmer; Torres Simón, Lucía; Doval Moreno, Sandra; Marcos Dolado, Alberto; Bruña Fernández, Ricardo; Maestu Unturbe, FernandoDelayed recall (DR) impairment is one of the most significant predictive factors in defining the progression to Alzheimer’s disease (AD). Changes in brain functional connectivity (FC) could accompany this decline in the DR performance even in a resting state condition from the preclinical stages to the diagnosis of AD itself, so the characterization of the relationship between the two phenomena has attracted increasing interest. Another aspect to contemplate is the potential moderator role of the APOE genotype in this association, considering the evidence about their implication for the disease. 379 subjects (118 mild cognitive impairment (MCI) and 261 cognitively intact (CI) individuals) underwent an extensive evaluation, including MEG recording. Applying cluster-based permutation test, we identified a cluster of differences in FC and studied which connections drove such an effect in DR. The moderation effect of APOE genotype between FC results and delayed recall was evaluated too. Higher FC in beta band in the right occipital region is associated with lower DR scores in both groups. A significant anteroposterior link emerged in the seed-based analysis with higher values in MCI. Moreover, APOE genotype appeared as a moderator between beta FC and DR performance only in the CI group. An increased beta FC in the anteroposterior brain region appears to be associated with lower memory performance in MCI. This finding could help discriminate the pattern of the progression of healthy aging to MCI and the relation between resting state and memory performance.Item A systematic review of normative data for verbal fluency test in different languages(Neuropsychology Review, 2022) Torres Simón, Lucía; Pacios García, Javier; Paul Lapedriza, Nuria Ascensión; Del Río Grande, David Pedro; Villalobos Tornero, María DoloresVerbal fluency tests are easy and quick to use in neuropsychological assessments, so they have been counted among the most classical tools in this context. To date, several normative data for verbal fluency tests have been provided in different languages and countries. A systematic review was carried out with studies that provide normative data for verbal fluency tests. Studies were collected from Scopus, PubMed and Web of Science. 183 studies were retrieved from the database search, of which 73 finally met the inclusion criteria. An analysis of the risk of bias regarding samples selection/characterization and procedure/results reports is conducted for each article. Finally, a full description of the normative data characteristics, considering country and language, verbal fluency task characteristics (type of task) and sample characteristics (number of subjects, gender, age, education) is included. The current systematic review provides an overview and analysis of internationally published normative data that might help clinicians in their search for valid and useful norms on verbal fluency tasks, as well as updated information about qualitative aspects of the different options currently available.Item The effects of white matter hyperintensities on MEG power spectra in population with mild cognitive impairment(Frontiers in Human Neuroscience, 2023) Torres Simón, Lucía; Cuesta Prieto, Pablo; del Cerro León, Alberto; Chino, Brenda; Orozco, Lucia H.; Marsh, Elisabeth B.; Gil Gregorio, Pedro; Maestu Unturbe, FernandoCerebrovascular disease is responsible for up to 20% of cases of dementia worldwide, but also it is a major comorbid contributor to the progression of other neurodegenerative diseases, like Alzheimer’s disease. White matter hyperintensities (WMH) are the most prevalent imaging marker in cerebrovascular disease. The presence and progression of WMH in the brain have been associated with general cognitive impairment and the risk to develop all types of dementia. The aim of this piece of work is the assessment of brain functional differences in an MCI population based on the WMH volume. One-hundred and twenty-nine individuals with mild cognitive impairment (MCI) underwent a neuropsychological evaluation, MRI assessment (T1 and Flair), and MEG recordings (5 min of eyes closed resting state). Those participants were further classified into vascular MCI (vMCI; n = 61, mean age 75 ± 4 years, 35 females) or non-vascular MCI (nvMCI; n = 56, mean age 72 ± 5 years, 36 females) according to their WMH total volume, assessed with an automatic detection toolbox, LST (SPM12). We used a completely data-driven approach to evaluate the differences in the power spectra between the groups. Interestingly, three clusters emerged: One cluster with widespread larger theta power and two clusters located in both temporal regions with smaller beta power for vMCI compared to nvMCI. Those power signatures were also associated with cognitive performance and hippocampal volume. Early identification and classification of dementia pathogenesis is a crucially important goal for the search for more effective management approaches. These findings could help to understand and try to palliate the contribution of WMH to particular symptoms in mixed dementia progress.Item Understanding brain function in vascular cognitive impairment and dementia with EEG and MEG: A systematic review(Neuroimage: clinical, 2022) Torres Simón, Lucía; Doval Moreno, Sandra; Nebreda Pérez, Alberto; Llinas, Sophia J.; Marsh, Elisabeth B.; Maestú Unturbe, FernandoVascular Cognitive Impairment (VCI) is the second most prevalent dementia after Alzheimer’s Disease (AD), and cerebrovascular disease (CBVD) is a major comorbid contributor to the progression of most neurodegenerative diseases. Early differentiation of cognitive impairment is critical given both the high prevalence of CBVD, and that its risk factors are modifiable. The ability for electroencephalogram (EEG) and magnetoencephalogram (MEG) to detect changes in brain functioning for other dementias suggests that they may also be promising biomarkers for early VCI. The present systematic review aims to summarize the literature regarding electrophysiological patterns of mild and major VCI. Despite considerable heterogeneity in clinical definition and electrophysiological methodology, common patterns exist when comparing patients with VCI to healthy controls (HC) and patients with AD, though there is a low specificity when comparing between VCI subgroups. Similar to other dementias, slowed frequency patterns and disrupted inter- and intra-hemispheric connectivity are repeatedly reported for VCI patients, as well as longer latencies and smaller amplitudes in evoked responses. Further study is needed to fully establish MEG and EEG as clinically useful biomarkers, including a clear definition of VCI and standardized methodology, allowing for comparison across groups and consolidation of multicenter efforts.Item Caracterización del funcionamiento cerebral, su estructura y la cognición asociados al daño cerebrovascular en el envejecimiento(2024) Torres Simón, Lucía; Maestu Unturbe, Fernando; Cuesta Prieto, PabloEl deterioro cognitivo vascular (DCV), también denominado demencia vascular (DVa), es responsable de hasta el 20% de los casos de demencia a nivel mundial (Kalaria, 2018). Además, las enfermedades cerebrovasculares también son un factor crucial en la progresión de otras demencias (Wardlaw et al., 2019). Aunque el daño cerebrovascular, especialmente las hiperintensidades de la sustancia blanca (WMH, en inglés), es intrínseco al envejecimiento, la acumulación o gravedad de estas afecciones están asociadas al deterioro cognitivo (Zimmerman et al., 2021). No obstante, existen evidencias de que la progresión puede ralentizarse controlando los factores de riesgo vascular y tratando las patologías subyacentes (Zimmerman et al., 2021). En consecuencia, la detección precoz y la diferenciación del origen vascular del deterioro cognitivo se convierten en un objetivo científico y clínico crucial, y en el propósito último de esta tesis.Existe mucha evidencia del del uso de la electrofisiología para la detección precoz y el pronóstico de diferentes trastornos neurodegenerativos (López-Sanz et al., 2019). Las alteraciones bioquímicas que se producen en la DCV pueden modificar la polaridad de las membranas celulares, los potenciales de acción y la comunicación célula-célula, alterando por completo el funcionamiento electrofisiológico del cerebro. Por lo tanto, parece razonable buscar nuevos biomarcadores electrofisiológicos para la diferenciación precoz de la DCV. Tras una extensa revisión sistemática, pudimos constatar que aún no estaban preparados para su inclusión en los criterios diagnósticos porque los resultados no eran lo suficientemente robustos como para ser utilizados como biomarcadores clínicos. Es en este contexto surge la motivación y los objetivos esta tesis, tratando de ofrecer soluciones específicas a las limitaciones percibidas de la literatura previa y encaminándose hacia la búsqueda de biomarcadores electrofisiológicos útiles para el DCV...