Person:
Roda Navarro, Pedro

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First Name
Pedro
Last Name
Roda Navarro
URI
https://hdl.handle.net/20.500.14352/78990
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Inmunología, Oftalmología y ORL
Area
Inmunología
Identifiers
UCM identifierORCIDScopus Author IDWeb of Science ResearcherIDDialnet IDGoogle Scholar ID

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2017 - 201912020 - 20224
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    Project number: 238
    Presentación y discusión de trabajos científicos de respuesta inmune a la infección en congresos
    () García de Yébenes Mena, Virginia; Roda Navarro, Pedro; Iborra Martín, Salvador; Fernández Messina, Lola María; Fernandez Arquero, Miguel; Álvarez Corrales, Emigdio; Redondo Urzainqui, Ana; Hernández García, Elena; Aguilar Sopeña, Óscar; Carrasco Padilla, Carlos
    El proyecto ha tenido como objetivo proporcionar a los alumnos del máster de Investigación en Inmunología de la UCM una formación teórica y práctica para la presentación de trabajos científicos en congresos. Se ha desarrollado una reunión científica en la que los alumnos han presentado y discutido trabajos científicos relevantes relacionados con la asignatura “Interacción Patógeno Sistema Inmunitario (607653)” en los formatos de presentación oral y presentación en póster que se utilizan en las reuniones científicas
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    Project number: 415
    Hacia una estrategia de internalización común en la Facultad de Medicina en particular y en la UCM en general
    (2021) Cubero Palero, Francisco Javier; Nevzorova, Yulia; Sanz García, Carlos; Martinez Naves, Eduardo; Martín Adrados, Beatriz; Estevez Vázquez, Olga; Roda Navarro, Pedro; Aguilar Sopeña, Óscar
    Este proyecto se basa en diseñar una estrategia para la internalización de las asignaturas de grado y posgrado de la Facultad de Medicina, especialmente los impartidos por el Departamento de Inmunología, Oftalmología y ORL.
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    Effect of Pharmacological Inhibition of the Catalytic Activity of Phosphatases of Regenerating Liver in Early T Cell Receptor Signaling Dynamics and IL-2 Production
    (International Journal of Molecular Sciences, 2020) Aguilar Sopeña, Óscar; Hernández Pérez, Sara; Alegre Gómez, Sergio; Castro Sánchez, Patricia; Iglesias Ceacero, Alba; Lazo, John S.; Roda Navarro, Pedro
    We have previously shown the delivery of phosphatase of regenerating liver-1 (PRL-1) to the immunological synapse (IS) and proposed a regulatory role of the catalytic activity of PRLs (PRL-1, PRL-2 and PRL-3) in antigen-induced IL-2 production. Nonetheless, the expression in T cells and delivery to the IS of the highly homologous PRL-3, as well as the role of the catalytic activity of PRLs in antigen-induced early signaling, has not been investigated. Here, the expression of PRL-3 protein was detected in primary CD4 T cells and in the CD4 T cell line Jurkat (JK), in which an overexpressed GFP-PRL-3 fluorescent fusion protein trafficked through the endosomal recycling compartment and co-localized with PLCγ1 signaling sites at the IS. Pharmacological inhibition was used to compare the role of the catalytic activity of PRLs in antigen-induced early signaling and late IL-2 production. Although the phosphatase activity of PRLs was not critical for early signaling triggered by antigen, it seemed to regulate signaling dynamics and was necessary for proper IL-2 production. We propose that enzymatic activity of PRLs has a higher significance for cytokine production than for early signaling at the IS. However, further research will be necessary to deeply understand the regulatory role of PRLs during lymphocyte activation and effector function.
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    mRNA profilin identifies low levels of phosphatases dual-specific phosphatase-7 (DUSP7) and cell division cycle-25B (CDC25B) in patients with early arthritis
    (CLINICAL AND EXPERIMENTAL IMMUNOLOGY: The journal of translational immunology, 2017) Castro-Sánchez, P.; Ramírez Muñoz, Rocío; Lamana Domínguez, Amalia; Ortiz, A.; González-Álvaro, I.; Roda Navarro, Pedro; Oxford University Press
    Phosphotyrosine phosphatases (PTPs) control phosphorylation levels and, consequently, regulate the output of intracellular signalling networks in health and disease. Despite the high number of PTPs expressed in CD4 T cells and their involvement in autoimmunity, information about the expression profile of PTPs in these cells has not been obtained in patients diagnosed with autoimmune diseases. Here, we compare the expression profile of PTPs in CD4 T cells of healthy volunteers and patients submitted to an early arthritis clinic, due to suspicion of rheumatoid arthritis, an autoimmune disease mediated by CD4 T cells. We found lower transcript levels of the mitogen-activated protein kinase (MAPK) phosphatase dual-specific phosphatase-7 (DUSP7) and the cell division cycle-25B (CDC25B) in T cells of patients. While the low expression level of DUSP7 was restricted to patients with positive rheumatoid factor and anti-citrullinated protein antibodies, the altered expression of CDC25B correlated with the activity of the disease. Low levels of CDC25B might contribute to the progression of the autoimmune arthritis and/or might be consequence of the inflammatory environment in the active disease. The possible role of DUSP7 and CDC25B as biomarkers of the disease in clinical protocols is discussed.
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    Bispecific Antibody Format and the Organization of Immunological Synapses in T Cell-Redirecting Strategies for Cancer Immunotherapy
    (Pharmaceutics, 2022) Carrasco Padilla, Carlos; Hernaiz Esteban, Alicia; Álvarez Vallina, Luis; Aguilar Sopeña, Óscar; Roda Navarro, Pedro
    T cell-redirecting strategies have emerged as effective cancer immunotherapy approaches. Bispecific antibodies (bsAbs) are designed to specifically recruit T cells to the tumor microenvironment and induce the assembly of the immunological synapse (IS) between T cells and cancer cells or antigen-presenting cells. The way that the quality of the IS might predict the effectiveness of T cell-redirecting strategies, including those mediated by bsAbs or by chimeric antigen receptors (CAR)-T cells, is currently under discussion. Here we review the organization of the canonical IS assembled during natural antigenic stimulation through the T cell receptor (TCR) and to what extent different bsAbs induce T cell activation, canonical IS organization, and effector function. Then, we discuss how the biochemical parameters of different formats of bsAbs affect the effectivity of generating an antigen-induced canonical IS. Finally, the quality of the IS assembled by bsAbs and monoclonal antibodies or CAR-T cells are compared, and strategies to improve bsAb-mediated T cell-redirecting strategies are discussed.
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    Project number: 325
    Formación para la presentación y discusión de trabajos científicos en congresos
    (2022) García de Yébenes Mena, Virginia; Alegre Gómez, Sergio; Álvarez Corrales, Emigdio Arián; Fernández Boraita, Julia Belén; Guerra Pérez, Natalia; Roda Navarro, Pedro
    El proyecto tiene como objetivo proporcionar a los alumnos del máster de Investigación en Inmunología de la UCM una formación teórica y práctica para la presentación de trabajos científicos en congresos en formatos de presentación oral y en póster.