Person: Garcimartín Álvarez, Alba
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First Name
Alba
Last Name
Garcimartín Álvarez
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Farmacología, Farmacognosia y Botánica
Area
Farmacología
Identifiers
31 results
Search Results
Now showing 1 - 10 of 31
Item Effects of Fiber Purified Extract of Carob Fruit on Fat Digestion and Postprandial Lipemia in Healthy Rats(Journal of Agricultural and Food Chemistry, 2018) Macho González, Adrián; Garcimartín Álvarez, Alba; Naes, F.; López-Oliva Muñoz, María Elvira; Amores-Arrojo, A.; González Muñoz, M. J.; Bastida Codina, Sara; Benedí González, Juana María; Sánchez Muniz, Francisco JoséIncreased postprandial lipemia is a cardiovascular disease (CVD) risk factor. Carob fruit extract (CFE) contains condensed tannins, and their intake has been inversely related to CVD. The objective was to evaluate the in vitro pancreatic lipase activity in the presence of CFE and the in vivo effect of CFE on postprandial lipemia of healthy Wistar rats in acute and subchronic digestibility studies and to relate it with changes in fat digestion and absorption. CFE significantly reduced pancreatic lipase activity. A peak delay and a dose-dependent decrease in plasma triglyceride and cholesterol areas under the curve were observed, effects that increased after the subchronic treatment. The levels of nondigested, nonabsorbed triglycerides of the remaining intestinal lumen fat were significantly higher in the maximum dose of CFE administrated versus the control (P < 0.05). This study demonstrates for the first time the hypolipemic properties of CFE from the first administration, modifying postprandial lipemia by reducing the extents of fat digestion and absorption.Item Identificación de problemas relacionados con el medicamento y estrategias de mejora en personas mayores(2020) Fernández Alfonso, María Soledad; Cea Soriano, Trinidad Lucia; Astasio Arbiza, Paloma; Bedoya del Olmo, Luis Miguel; Garcia Broncano, Rosario; García Ferrera, Alicia; García García, Luis; Garcimartín Álvarez, Alba; Gómez Oliver, Francisca; González Burgos, Elena María; Guerra Guirao, Jose Antonio; Manouchehri, Marjan; Manzano Lista, Francisco Javier; Ortega Molina, Paloma; Pulido Manzanero, José; Sánchez Ortíz, Sara; Santos Sancho, Juana- Project number: 145
Item UCMspace-comunica)))), un espacio web como herramienta de aprendizaje de carácter multidisciplinar para la mejora de la comunicación científica(2017) Ortega Hernández-Agero, Teresa; Torres Muñoz, Margarita; Benedí González, Juana María; Raposo González, Rafaela; De las Heras Polo, Beatriz; Palomino Ruiz-Poveda, Olga; Martín Gómez, María Soledad; Pintado Valverde, Ana; Sánchez de Rojas Fernández-Cabrera, Ramón; Castilla Rodriguez, Carlos María; Garcimartín Álvarez, AlbaDiseño, ejecución y evaluación de un espacio web (UCMspace-comunica)))), que pueda ser utilizado como herramienta de aprendizaje eficaz, de carácter multidisciplinar, para la correcta comunicación de los contenidos específicos adquiridos por los alumnos en las diferentes materias que integran los grados universitarios, incluyendo el Trabajo Fin de Grado. Esta herramienta puede ser útil para optimizar la labor tutorial del profesor y el desarrollo profesional de los futuros farmacéuticos. - Project number: 116
Item Elaboración de un espacio virtual de auto aprendizaje, mediante trabajo colaborativo, para el desarrollo y aplicación de competencias de Atención Farmacéutica.(2016) Benedí González, Juana María; Iglesias Peinado, Irene; Raposo Simon, Carlos; García Diz, Luis; Romero Garrido, Jose A.; Garcimartín Álvarez, Alba Item Elevated Systemic L-Kynurenine/L-Tryptophan Ratio and Increased IL-1 Beta and Chemokine (CX3CL1, MCP-1) Proinflammatory Mediators in Patients with Long-Term Titanium Dental Implants(Journal of Clinical Medicine, 2019) Merino Martín, José Joaquín; Cabaña-Muñoz, María Eugenia; Toledano Gasca, Adolfo; Garcimartín Álvarez, Alba; Benedí González, Juana María; Camacho-Alonso, Fabio; Parmigiani-Izquierdo, José MaríaTitanium is the mean biocompatible metal found in dental titanium alloys (Ti-6Al-4V). The safety of certain dental biomaterial amalgams has been questioned in patients. The levels of several systemic cytokines (interleukin (IL)-1 beta, IL-4: pg/mL) and chemokines (monocyte chemoattractant protein-1 (MCP-1), soluble fractalkine (CX3CL1: pg/mL) were determined using ELISA and compared between these study groups. The study included 30 controls without dental materials (cont), 57 patients with long-term titanium dental implants plus amalgams (A + I group) as well as 55 patients with long-term dental amalgam alone (A group). All patients (except controls) have had dental titanium implants (Ti-6Al-4V) and/or amalgams for at least 10 years (average: 15 years). We evaluated whether systemic levels of cytokines/chemokines, kyn/L-trp ratio and aromatic amino acid levels (HPLC: mM/L, Phe, L-Trp, His, Treo) could be altered in patients with long-term dental titanium and/or amalgams. These systemic markers were evaluated in 142 patients. The A + I group had higher L-Kynurenine/L-Tryptophan ratios than patients with long-term dental amalgam fillings alone (A). In addition, levels of IL-1 Beta cytokine, CX3CL1 and MCP-1 chemokines were higher in the A + I group than in the A group (A). The increased L-kyn/L-trp ratio and MCP-1 and fractalkine receptor (CX3CR1) elevations could suggest enhanced chemotactic responses by these chemokines in the A + I group.- Project number: 277
Item Elaboración de casos clínicos como estrategia de conocimiento situado para alcanzar un aprendizaje profundo(2021) Garcimartín Álvarez, Alba; García Aguilar, Ana; Bocanegra De Juana, Aranzazu; González Burgos, Elena María; Gómez Oliver, Francisca; Guerra Guirao, José Antonio; Merino Martín, José Joaquín; Bedoya del Olmo, Luis Miguel; García García, Luis; Fernández Alfonso, María Soledad; Garcia Broncano, Rosario; Manzano Lista, Francisco Javier; Ureña Vacas, Isabel; Hernández Martín, MarinaLa elaboración de un caso clínico personalizado permite al estudiante vivenciar el conocimiento y la aplicación real e inmediata de la asignatura, aspecto crucial para reorientar su motivación y alcanzar un aprendizaje profundo. Item Carob fruit extract-enriched meat, as preventive and curative treatments, improves gut microbiota and colonic barrier integrity in a late-stage T2DM model(Food Research International, 2021) Macho González, Adrián; Garcimartín Álvarez, Alba; Redondo, Noemí; Cofrades, Susana; Bastida Codina, Sara; Nova, Esther; Benedí González, Juana María; Sánchez Muniz, Francisco José; Marcos, Ascensión; López-Oliva Muñoz, María ElviraEpidemiological and experimental studies have suggested that dietary fiber and proanthocyanidins play an important role on gut microbiota (GM), colonic integrity and body health. Type 2 Diabetes Mellitus (T2DM) is a prevalent disease in which the modifications in the GM and colonic markers stand out. This manuscript hypothesizes the consumption of functional meat enriched in carob fruit extract [CFE; CFE-restructured meat (RM)] ameliorates the dysbiosis and colonic barrier integrity loss in a late-stage T2DM rat model induced by the conjoint action of a high-saturated-fat/high-cholesterol diet (Chol-diet) and a low dose of streptozotocin (STZ) plus a nicotinamide (NAD) injection. Three groups of eight rats were used: (1) D group, a T2DM control group, fed the Chol-diet; (2) ED group, a T2DM preventive strategy group fed the CFE-Chol-diet since the beginning of the study; and (3) DE group, a T2DM curative treatment group, fed the CFE-Chol-diet once the diabetic state was confirmed. The study lasted 8 weeks. Amount and variety of GM, feces short-chain-fatty acids (SCFAs), colonic morphology [crypt depth and density, goblet cells, proliferating cell nuclear antigen (PCNA) and transferase dUTP nick end labelling (TUNEL) indexes] and tight junctions were evaluated. A global colonic index combining 17 markers (GCindex) was calculated. ED rats displayed higher levels of GM richness, SCFAs production, crypt depth, and goblet cells than the D group. DE group showed lower Enterobacteriaceae abundance and greater TUNEL index and occludin expression in the distal colon than D counterpart. GCindex differentiated the colonic health status of the experimental groups in the order (ED > DE > D; P < 0.001) as a 17–51 range-quotation, ED, DE, and D groups displayed the values 43, 32.5, and 27, respectively. Thus, CFE-RM used as a T2DM preventive therapy could induce higher GM richness, more adequate SCFAs production, and better colonic barrier integrity. Furthermore, CFE-RM used with curative purposes induced more modest changes and mainly at the distal colonic mucosa. Further studies are needed to confirm this study’s results, to ascertain the benefits of consuming proanthocyanidins-rich fiber during different T2DM stages.Item Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?(Nutrients, 2019) Macho González, Adrián; Garcimartín Álvarez, Alba; López-Oliva Muñoz, María Elvira; Ruiz-Roso, Baltasar; Martín de la Torre, Isabel; Bastida Codina, Sara; Benedí González, Juana María; Sánchez Muniz, Francisco JoséCarob fruit extract (CFE) has shown remarkable in vitro antioxidant properties and reduces postprandial hyperglycemia and hyperlipidemia in healthy animals. Development of functional meat products that contain bioactive components are presented as a great nutritional strategy. Until now, the effect of the consumption of restructured meat enriched with CFE in a murine model of diabetes has not been investigated. The objective of this study was to evaluate the effect on glycemia, lipemia, lipoprotein profile, Ldlr, arylesterase (AE), and very low density lipoproteins (VLDL) and liver oxidation in streptozotocin-nicotinamide (STZ-NAD) growing Wistar diabetic rats fed restructured meat in the frame of a high cholesterol/high saturated-fat diet. In the present study, three groups (D, ED and DE) were fed cholesterol-enriched (1.4% cholesterol and 0.2% cholic acid) and high saturated fat diets (50% of total energy from fats and 20.4% from saturated fatty acids). Rats were subjected to a STZ-NAD administration at the 3rd week. Group D did not receive CFE, while ED and DE rat groups received CFE before and after the diabetic induction, respectively. After eight weeks, D rats showed hyperglycemia and hypercholesterolemia, an increased amount cholesterol-enriched VLDL (β-VLDL), IDL and LDL particles and triglyceride-enriched HDL. ED and DE partially blocked the hypercholesterolemic induction with respect to D group (p < 0.001) and improved glycemia, cholesterol levels, lipoprotein profile, Ldlr, plasma AE activity and liver oxidation (p < 0.001). Fecal fat, moisture and excretion were higher while dietary digestibility was lower in ED and DE vs. D counterparts (p < 0.0014). In conclusion, CFE enriched meat shows, for the first time, hypoglycemic and hypolipidemic effects in STZ-NAD animals fed high cholesterol/high saturated-fat diets. Likewise, it manages to reverse possible diabetes lipoprotein alterations if CFE enriched meat is consumed before pathology development or improves said modifications if Type 2 Diabetes Mellitus is already established.Item The Nutritional Components of Beer and Its Relationship with Neurodegeneration and Alzheimer’s Disease(Nutrients, 2019) Sánchez Muniz, Francisco José; Macho González, Adrián; Garcimartín Álvarez, Alba; Santos López, Jorge Arturo; Benedí González, Juana María; Bastida Codina, Sara; González-Muñoz, María JoséThe prevalence of degenerative diseases has risen in western countries. Growing evidence suggests that demenia and other cognition affectations are associated with ambient factors including specific nutrients, food ingredients or specific dietary patterns. Mediterranean diet adherence has been associated with various health benefits and decreased risk of many diseases, including neurodegenerative disorders. Beer, as part of this protective diet, contains compounds such as silicon and hops that could play a major role in preventing brain disorders. In this review, different topics regarding Mediterranean diet, beer and the consumption of their main compounds and their relation to neurological health have been addressed. Taking into account published results from our group and other studies, the hypothesis linking aluminum intoxication with dementia and/or Alzheimer’s disease and the potential role of regular beer has also been considered. Beer, in spite of its alcohol content, may have some health benefits; nonetheless, its consumption is not adequate for all subjects. Thus, this review analyzed some promising results of non-alcoholic beer on several mechanisms engaged in neurodegeneration such as inflammation, oxidation, and cholinesterase activity, and their contribution to the behavioral modifications induced by aluminum intoxication. The review ends by giving conclusions and suggesting future topics of research related to moderate beer consumption and/or the consumption of its major compounds as a potential instrument for protecting against neurodegenerative disease progression and the need to develop nutrigenetic and nutrigenomic studies in aged people and animal models.Item Whole Alga, Algal Extracts, and Compounds as Ingredients of Functional Foods: Composition and Action Mechanism Relationships in the Prevention and Treatment of Type-2 Diabetes Mellitus(International Journal of Molecular Sciences, 2021) Bocanegra De Juana, Aranzazu; Macho González, Adrián; Garcimartín Álvarez, Alba; Benedí González, Juana María; Sánchez Muniz, Francisco JoséType-2 diabetes mellitus (T2DM) is a major systemic disease which involves impaired pancreatic function and currently affects half a billion people worldwide. Diet is considered the cornerstone to reduce incidence and prevalence of this disease. Algae contains fiber, polyphenols, ω-3 PUFAs, and bioactive molecules with potential antidiabetic activity. This review delves into the applications of algae and their components in T2DM, as well as to ascertain the mechanism involved (e.g., glucose absorption, lipids metabolism, antioxidant properties, etc.). PubMed, and Google Scholar databases were used. Papers in which whole alga, algal extracts, or their isolated compounds were studied in in vitro conditions, T2DM experimental models, and humans were selected and discussed. This review also focuses on meat matrices or protein concentrate-based products in which different types of alga were included, aimed to modulate carbohydrate digestion and absorption, blood glucose, gastrointestinal neurohormones secretion, glycosylation products, and insulin resistance. As microbiota dysbiosis in T2DM and metabolic alterations in different organs are related, the review also delves on the effects of several bioactive algal compounds on the colon/microbiota-liver-pancreas-brain axis. As the responses to therapeutic diets vary dramatically among individuals due to genetic components, it seems a priority to identify major gene polymorphisms affecting potential positive effects of algal compounds on T2DM treatment.