Garcimartín Álvarez, Alba

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First Name
Last Name
Garcimartín Álvarez
Universidad Complutense de Madrid
Faculty / Institute
Farmacología, Farmacognosia y Botánica
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Now showing 1 - 10 of 20
  • Publication
    Can Carob-Fruit-Extract-Enriched Meat Improve the Lipoprotein Profile, VLDL-Oxidation, and LDL Receptor Levels Induced by an Atherogenic Diet in STZ-NAD-Diabetic Rats?
    (MDPI, 2019-02-03) Macho González, Adrián; Garcimartín Álvarez, Alba; López-Oliva Muñoz, María Elvira; Ruiz-Roso, Baltasar; Martín de la Torre, Isabel; Bastida Codina, Sara; Benedí González, Juana María; Sánchez Muniz, Francisco José
    Carob fruit extract (CFE) has shown remarkable in vitro antioxidant properties and reduces postprandial hyperglycemia and hyperlipidemia in healthy animals. Development of functional meat products that contain bioactive components are presented as a great nutritional strategy. Until now, the effect of the consumption of restructured meat enriched with CFE in a murine model of diabetes has not been investigated. The objective of this study was to evaluate the effect on glycemia, lipemia, lipoprotein profile, Ldlr, arylesterase (AE), and very low density lipoproteins (VLDL) and liver oxidation in streptozotocin-nicotinamide (STZ-NAD) growing Wistar diabetic rats fed restructured meat in the frame of a high cholesterol/high saturated-fat diet. In the present study, three groups (D, ED and DE) were fed cholesterol-enriched (1.4% cholesterol and 0.2% cholic acid) and high saturated fat diets (50% of total energy from fats and 20.4% from saturated fatty acids). Rats were subjected to a STZ-NAD administration at the 3rd week. Group D did not receive CFE, while ED and DE rat groups received CFE before and after the diabetic induction, respectively. After eight weeks, D rats showed hyperglycemia and hypercholesterolemia, an increased amount cholesterol-enriched VLDL (β-VLDL), IDL and LDL particles and triglyceride-enriched HDL. ED and DE partially blocked the hypercholesterolemic induction with respect to D group (p < 0.001) and improved glycemia, cholesterol levels, lipoprotein profile, Ldlr, plasma AE activity and liver oxidation (p < 0.001). Fecal fat, moisture and excretion were higher while dietary digestibility was lower in ED and DE vs. D counterparts (p < 0.0014). In conclusion, CFE enriched meat shows, for the first time, hypoglycemic and hypolipidemic effects in STZ-NAD animals fed high cholesterol/high saturated-fat diets. Likewise, it manages to reverse possible diabetes lipoprotein alterations if CFE enriched meat is consumed before pathology development or improves said modifications if Type 2 Diabetes Mellitus is already established.
  • Publication
    Elaboración de casos clínicos como estrategia de conocimiento situado para alcanzar un aprendizaje profundo
    (2021-09-06) Garcimartín Álvarez, Alba; García Aguilar, Ana; Bocanegra De Juana, Aránzazu; González Burgos, Elena; Gómez Oliver, Francisca; Guerra Guirao, José Antonio; Merino Martín, José Joaquín; Bedoya del Olmo, Luis Miguel; García García, Luis; Fernández Alfonso, María Soledad; Garcia Broncano, Rosario; Manzano Lista, Francisco Javier; Ureña Vacas, Isabel; Hernández Martín, Marina
    La elaboración de un caso clínico personalizado permite al estudiante vivenciar el conocimiento y la aplicación real e inmediata de la asignatura, aspecto crucial para reorientar su motivación y alcanzar un aprendizaje profundo.
  • Publication
    The Impact of CXCR4 Blockade on the Survival of Rat Brain Cortical Neurons
    (MDPI, 2016-11-30) Merino Martín, José Joaquín; Garcimartín Álvarez, Alba; López-Oliva Muñoz, María Elvira; Benedí González, Juana María; González Burgos, Elena
    Background: Chemokine receptor type 4 (CXCR4) plays a role in neuronal survival/cell repair and also contributes to the progression of cancer and neurodegenerative diseases. Chemokine ligand 12 (CXCL12) binds to CXCR4. In this study, we have investigated whether CXCR4 blockade by AMD3100 (a CXCR4 antagonist, member of bicyclam family) may affect neuronal survival in the absence of insult. Thus, we have measured the mitochondrial membrane potential (MMP), Bax and Bcl-2 protein translocation, and cytochrome c release in AMD3100-treated brain cortical neurons at 7 DIV (days in vitro). Methods: For this aim, AMD3100 (200 nM) was added to cortical neurons for 24 h, and several biomarkers like cell viability, reactive oxygen species (ROS) generation, lactate dehydrogenase (LDH) release, caspase-3/9 activity, proteins Bax and Bcl-2 translocation, and cytochrome c release were analyzed by immunoblot. Results: CXCR4 blockade by AMD3100 (200 nM, 24 h) induces mitochondrial hyperpolarization and increases caspase-3/9 hyperpolarization without affecting LDH release as compared to untreated controls. AMD3100 also increases cytochrome c release and promotes Bax translocation to the mitochondria, whereas it raises cytosolic Bcl-2 levels in brain cortical neurons. Conclusion: CXCR4 blockade induces cellular death via intrinsic apoptosis in rat brain cortical neurons in absence of insult.
  • Publication
    Creación de un canal de Youtube con vídeos cortos de Farmacología para favorecer el aprendizaje activo y la transferencia del conocimiento
    (2022-06-29) García Aguilar, Ana; Garcimartín Álvarez, Alba; Bocanegra De Juana, Aránzazu; González Burgos, Elena; Merino Martín, José Joaquín; García García, Luis; Fernández Alfonso, María Soledad; Garcia Broncano, Rosario; Manzano Lista, Francisco Javier; Ureña Vacas, Isabel; Hernández Martín, Marina; Redondo Castillejo, Rocío; Garrido Garrido, Gabino; Valdés González, Marisela
    La elaboración de vídeos cortos de farmacología y la creación de un repositorio virtual para visualizarlos permitirá al alumnado adquirir los conocimientos y relacionarlos para alcanzar un aprendizaje activo individual y colectivo y favorecer la transferencia del conocimiento
  • Publication
    Could Duodenal Molecular Mechanisms be Involved in the Hypocholesterolemic Effect of Silicon Used as Functional Ingredient in Late‐Stage Type 2 Diabetes Mellitus?
    (Wiley, 2022-10-10) Hernández Martín, Marina; Bocanegra De Juana, Aránzazu; Redondo Castillejo, Rocío; Macho González, Adrián; Sánchez Muniz, Francisco José; Benedí González, Juana María; Bastida Codina, Sara; García Fernández, Rosa Ana; Garcimartín Álvarez, Alba; López Oliva, M. Elvira
    Scope: Hypercholesterolemia increases the risk of mortality in type 2 diabetesmellitus (T2DM), especially in the late-stage. Consumption of bioactivecompounds as functional ingredients would help achieve therapeutic goals forcholesterolemia. Silicon has demonstrated a hypocholesterolemic effect andthe ability to reduce fat digestion. However, it is unclear whether silicon exertssuch effect in late-stage T2DM (LD) and the intestinal mechanisms involved.Methods and results: Three groups of eight rats were included: early-stageT2DM control (ED), LD, and the LD group treated with silicon (LD-Si) oncethe rats were diabetic. Morphological alterations of the duodenal mucosa, andlevels of markers involve in cholesterol absorption and excretion, besidecholesterolemia, and fecal excretion were assayed. Silicon included as afunctional ingredient significantly reduces cholesterolemia in part due to: 1)reducing cholesterol intestinal absorption by decreasing the absorptive areaand Acetyl-Coenzyme A acetyltransferase-2 (ACAT2) levels; and 2) increasingcholesterol excretion to the lumen by induction of the liver X receptor (LXR)and consequent increase of adenosine triphosphate-binding cassettetransporter (ABCG5/8).Conclusions: These results provide insight into the intestinal molecularmechanisms by which silicon reduces cholesterolemia and highlights theefficacy of the consumption of silicon-enriched functional foods in late-stageT2DM.
  • Publication
    Casos clínicos como recursos educativos abiertos para fomentar el aprendizaje significativo de la Farmacología General
    González Burgos, Elena; Fernández Alonso, Soledad; Gómez Oliver, Francisca; García García, Luis; Garcimartín Álvarez, Alba; Bocanegra De Juana, Aránzazu; García Aguilar, Ana; Ureña Vacas, Isabel; Manzano Lista, Francisco Javier; Redondo Castillejo, Rocío; Garcia Broncano, Rosario
  • Publication
    Elevated Systemic L-Kynurenine/L-Tryptophan Ratio and Increased IL-1 Beta and Chemokine (CX3CL1, MCP-1) Proinflammatory Mediators in Patients with Long-Term Titanium Dental Implants
    (MDPI, 2019-09-02) Merino Martín, José Joaquín; Cabaña-Muñoz, María Eugenia; Toledano Gasca, Adolfo; Garcimartín Álvarez, Alba; Benedí González, Juana María; Camacho-Alonso, Fabio; Parmigiani-Izquierdo, José María
    Titanium is the mean biocompatible metal found in dental titanium alloys (Ti-6Al-4V). The safety of certain dental biomaterial amalgams has been questioned in patients. The levels of several systemic cytokines (interleukin (IL)-1 beta, IL-4: pg/mL) and chemokines (monocyte chemoattractant protein-1 (MCP-1), soluble fractalkine (CX3CL1: pg/mL) were determined using ELISA and compared between these study groups. The study included 30 controls without dental materials (cont), 57 patients with long-term titanium dental implants plus amalgams (A + I group) as well as 55 patients with long-term dental amalgam alone (A group). All patients (except controls) have had dental titanium implants (Ti-6Al-4V) and/or amalgams for at least 10 years (average: 15 years). We evaluated whether systemic levels of cytokines/chemokines, kyn/L-trp ratio and aromatic amino acid levels (HPLC: mM/L, Phe, L-Trp, His, Treo) could be altered in patients with long-term dental titanium and/or amalgams. These systemic markers were evaluated in 142 patients. The A + I group had higher L-Kynurenine/L-Tryptophan ratios than patients with long-term dental amalgam fillings alone (A). In addition, levels of IL-1 Beta cytokine, CX3CL1 and MCP-1 chemokines were higher in the A + I group than in the A group (A). The increased L-kyn/L-trp ratio and MCP-1 and fractalkine receptor (CX3CR1) elevations could suggest enhanced chemotactic responses by these chemokines in the A + I group.
  • Publication
    Implementación del aprendizaje-servicio en “Farmacología General” como estrategia para fomentar el conocimiento significativo.
    (2020-10-05) Fernández Alfonso, María Soledad; Garcimartín Álvarez, Alba; González Burgos, Elena; García García, Luis; Bedoya del Olmo, Luis Miguel; Gómez Oliver, Francisca; Guerra Guirao, José Antonio; Manouchehri, Marjan; Manzano Lista, Francisco Javier; Ureña Vacas, Isabel
  • Publication
    Dinamización del aprendizaje de Farmacología y Farmacoterapia mediante evaluación continua en entorno virtual
    (2019-06-29) Martín-Aragón Alvarez, Sagrario; Bermejo Bescós, María de la Paloma; Slowing Barillas, Karla Verónica; Garcimartín Álvarez, Alba; Benedí González, Juana María; Pérez Uz, María Blanca; Romero Garrido, José Antonio; Santos López, Jorge Arturo; Sánchez-Prieto Mateos, Alicia
    La Evaluación constituye un elemento clave de la tarea docente para incentivar el trabajo de los estudiantes, constatar sus progresos e introducir mejoras en la planificación y acción educativa. Un número considerable de estudiantes universitarios admite que sus conductas de estudio están bastante determinadas por su percepción del sistema de evaluación. Y así es; los docentes estamos observando que los estudiantes calculan cada vez más el uso del tiempo y de sus energías, influidos por las demandas percibidas del sistema de evaluación. Por tanto, el sistema de evaluación condicionará no sólo la consecución real de las competencias sino la forma de estudiar y el tiempo dedicado al aprendizaje. En este contexto, los estudiantes que participan en la evaluación continua tienen mayores garantías de superar una asignatura que el resto porque: a) asimilan de forma gradual los contenidos más importantes de la materia; b) desarrollan de forma gradual las competencias de la asignatura; c) conocen la forma de evaluar del profesor; y d) reciben información sobre su propio ritmo de aprendizaje, pudiendo así reorientarlo. Y, en último lugar, la evaluación continua prepara a los estudiantes para la prueba final de evaluación, ya que, por coherencia, el examen final debería poseer la misma o similar estructura que las actividades propuestas a lo largo del curso. Los entornos virtuales se presentan como una herramienta realmente útil para abordar el reto de la evaluación continua. La plataforma Moodle cuenta con diversos módulos y actividades que pueden ser evaluadas por el profesor, y que sirven para otorgar una calificación al estudiante. Entre estos se encuentra el módulo de «cuestionarios» que permite al profesor diseñar sus propios cuestionarios y aplicarlos a sus estudiantes de forma on-line. El presente proyecto propone la elaboración y aplicación de cuestionarios en Moodle, utilizando los diferentes tipos de preguntas disponibles, como herramienta para la evaluación continua en la asignatura de «Farmacología y Farmacoterapia» de 4º curso de Grado en Farmacia.
  • Publication
    The Nutritional Components of Beer and Its Relationship with Neurodegeneration and Alzheimer’s Disease
    (MDPI, 2019-07-10) Sánchez Muniz, Francisco José; Macho González, Adrián; Garcimartín Álvarez, Alba; Santos López, Jorge Arturo; Benedí González, Juana María; Bastida Codina, Sara; González-Muñoz, María José
    The prevalence of degenerative diseases has risen in western countries. Growing evidence suggests that demenia and other cognition affectations are associated with ambient factors including specific nutrients, food ingredients or specific dietary patterns. Mediterranean diet adherence has been associated with various health benefits and decreased risk of many diseases, including neurodegenerative disorders. Beer, as part of this protective diet, contains compounds such as silicon and hops that could play a major role in preventing brain disorders. In this review, different topics regarding Mediterranean diet, beer and the consumption of their main compounds and their relation to neurological health have been addressed. Taking into account published results from our group and other studies, the hypothesis linking aluminum intoxication with dementia and/or Alzheimer’s disease and the potential role of regular beer has also been considered. Beer, in spite of its alcohol content, may have some health benefits; nonetheless, its consumption is not adequate for all subjects. Thus, this review analyzed some promising results of non-alcoholic beer on several mechanisms engaged in neurodegeneration such as inflammation, oxidation, and cholinesterase activity, and their contribution to the behavioral modifications induced by aluminum intoxication. The review ends by giving conclusions and suggesting future topics of research related to moderate beer consumption and/or the consumption of its major compounds as a potential instrument for protecting against neurodegenerative disease progression and the need to develop nutrigenetic and nutrigenomic studies in aged people and animal models.