Person: Illescas Martínez, Beatriz María
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First Name
Beatriz María
Last Name
Illescas Martínez
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Ciencias Químicas
Department
Química Orgánica
Area
Química Orgánica
Identifiers
9 results
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Now showing 1 - 9 of 9
Item Enhanced Thermoelectricity in Metal–[60]Fullerene–Graphene Molecular Junctions(Nano Letters, 2023) Simon A. Svatek; Valentina Sacchetti; Rodríguez Pérez, Laura; Illescas Martínez, Beatriz María; Laura Rincón-García; Gabino Rubio-Bollinger; M. Teresa González; Steven Bailey; Colin J. Lambert; Martín León, Nazario; Nicolás AgraïtThe thermoelectric properties of molecular junctions consisting of a metal Pt electrode contacting [60]fullerene derivatives covalently bound to a graphene electrode have been studied by using a conducting-probe atomic force microscope (c-AFM). The [60]fullerene derivatives are covalently linked to the graphene via two meta-connected phenyl rings, two para-connected phenyl rings, or a single phenyl ring.We find that the magnitude of the Seebeck coefficient is up to nine times larger than that of Au−C60−Pt molecular junctions.Moreover,the sign of the thermopower can be either positiveor negative depending on the details of the binding geometry and on the local value of the Fermi energy. Our results demonstrate the potential of using graphene electrodes for controlling and enhancing the thermoelectric properties of molecular junctions and confirm the outstanding performance of [60]fullerene derivatives.Item Electron transfer through exTTF bridges in electron donor–acceptor conjugates(ChemComm, 2009) Martín, Nazario; Guldi, Dirk M.; Illescas Martínez, Beatriz María; Santos Barahona, Jose Manuel; Wielopolski, Mateusz; Atienza Castellanos, Carmen MaríaRigid and soluble electron donor–acceptor conjugates combining exTTF and/or TTF as donors and C60 as acceptor have been synthesized; fluorescence and transient absorption measurements confirm the generation of charge-separated radical-ion pairs with lifetimes in the ls timescale.Item Hexakis-adducts of [60]fullerene as molecular scaffolds of polynuclear spin-crossover molecules(Chemical Science, 2021) Palacios-Corella, Mario; Ramos-Soriano, Javier; Souto, Manuel; Ananias, Duarte; Calbo, Joaquín; Ortí, Enrique; Illescas Martínez, Beatriz María; Clemente-León, Miguel; Martín León, Nazario; Coronado, EugenioA family of hexakis-substituted [60]fullerene adducts endowed with the well-known tridentate 2,6- bis(pyrazol-1-yl)pyridine (bpp) ligand for spin-crossover (SCO) systems has been designed and synthesized. It has been experimentally and theoretically demonstrated that these molecular scaffolds are able to form polynuclear SCO complexes in solution. UV-vis and fluorescence spectroscopy studies have allowed monitoring of the formation of up to six Fe(II)–bpp SCO complexes. In addition, DFT calculations have been performed to model the different complexation environments and simulate their electronic properties. The complexes retain SCO properties in the solid state exhibiting both thermaland photoinduced spin transitions, as confirmed by temperature-dependent magnetic susceptibility and Raman spectroscopy measurements. The synthesis of these complexes demonstrates that [60]fullerene hexakis-adducts are excellent and versatile platforms to develop polynuclear SCO systems in which a fullerene core is surrounded by a SCO molecular shell.Item A 3D Peptide/[60]Fullerene hybrid for multivalent recognition(Angewandte Chemie International Edition, 2022) Cabrera González, Justo Enrique; Illescas Martínez, Beatriz María; Martín León, Nazario; Gallego, Iván; Ramos‐Soriano, Javier; Méndez‐Ardoy, Alejandro; Irene Lostalé‐Seijo; Jose J. Reina; Javier MontenegroFully substituted peptide/[60]fullerene hexakis‐adducts offer an excellent opportunity for multivalent protein recognition. In contrast to monofunctionalized fullerene hybrids, peptide/[60]fullerene hexakis‐adducts display multiple copies of a peptide in close spatial proximity and in the three dimensions of space. High affinity peptide binders for almost any target can be currently identified by in vitro evolution techniques, often providing synthetically simpler alternatives to natural ligands. However, despite the potential of peptide/[60]fullerene hexakis‐adducts, these promising conjugates have not been reported to date. Here we present a synthetic strategy for the construction of 3D multivalent hybrids that are able to bind with high affinity the E‐selectin. The here synthesized fully substituted peptide/[60]fullerene hybrids and their multivalent recognition of natural receptors constitute a proof of principle for their future application as functional biocompatible materials.Item C60-based Multivalent Glycoporphyrins Inhibit SARS-CoV-2 Specific Interaction with the DC-SIGN Transmembrane Receptor(Small, 2023) Rafael Delgado; Cabrera González, Justo Enrique; Illescas Martínez, Beatriz María; Martín León, Nazario; Canales Mayordomo, María Ángeles; López Montero, Iván; Delgado Vázquez, RafaelSince WHO has declared the COVID-19 outbreak a global pandemic, nearly seven million deaths have been reported. This efficient spread of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is facilitated by the ability of the spike glycoprotein to bind multiple cell membrane receptors. Although ACE2 is identified as the main receptor for SARS-CoV-2, other receptors could play a role in viral entry. Among others, C-type lectins such as DC-SIGN are identified as efficient trans-receptor for SARS-CoV-2 infection, so the use of glycomimetics to inhibit the infection through the DC-SIGN blockade is an encouraging approach. In this regard, multivalent nanostructures based on glycosylated [60]fullerenes linked to a central porphyrin scaffold have been designed and tested against DC-SIGN-mediated SARS-CoV-2 infection. First results show an outstanding inhibition of the trans-infection up to 90%. In addition, a deeper understanding of nanostructure-receptor binding is achieved through microscopy techniques, high-resolution NMR experiments, Quartz Crystal Microbalance experiments, and molecular dynamic simulations.Item Multivalent cationic dendrofullerenes for gene transfer: synthesis and DNA complexation(Journal of Materials Chemistry B, 2020) Illescas Martínez, Beatriz María; Pérez Sánchez, Alfonso; Mallo, Araceli; Martín Doménech, Ángel; Rodríguez Crespo, José Ignacio; Martín León, NazarioNon-viral nucleic acid vectors able to display high transfection efficiencies with low toxicity and overcoming the multiple biological barriers are needed to further develop the clinical applications of gene therapy. The synthesis of hexakis-adducts of [60]fullerene endowed with 12, 24 and 36 positive ammonium groups and a tridecafullerene appended with 120 positive charges has been performed. The delivery of a plasmid containing the green fluorescent protein (EGFP) gene into HEK293 (Human Embryonic Kidney) cells resulting in effective gene expression has demonstrated the efficacy of these compounds to form polyplexes with DNA. Particularly, giant tridecafullerene macromolecules have shown higher efficiency in the complexation and transfection of DNA. Thus, they can be considered as promising non-viral vectors for transfection purposes.Item Nanocarbon-Based Glycoconjugates as Multivalent Inhibitors of Ebola Virus Infection(Journal of the American Chemical Society, 2018) Rodríguez Pérez, Laura; Ramos-Soriano, Javier; Pérez Sánchez, Alfonso; Illescas Martínez, Beatriz María; Muñoz, Antonio; Luczkowiak, Joanna; Lasala, Fátima; Rojo, Javier; Delgado Vázquez, Rafael; Martín León, NazarioSWCNTs, MWCNTs, and SWCNHs have been employed as virus-mimicking nanocarbon platforms for the multivalent presentation of carbohydrates in an artificial Ebola virus infection model assay. These carbon nanoforms have been chemically modified by the covalent attachment of glycodendrons and glycofullerenes using the CuAAC “click chemistry” approach. This modification dramatically increases the water solubility of these structurally different nanocarbons. Their efficiency in blocking DC-SIGN-mediated viral infection by an artificial Ebola virus has been tested in a cellular experimental assay, finding that glycoconjugates based on MWCNTs functionalized with glycofullerenes are potent inhibitors of viral infection.Item Synthesis of Highly Efficient Multivalent Disaccharide/[60]Fullerene Nanoballs for Emergent Viruses(Journal of the American Chemical Society, 2019) Ramos-Soriano, Javier; Reina, José ; Illescas Martínez, Beatriz María; de la Cruz, Noelia; Rodríguez Pérez, Laura; Lasala, Fátima; Rojo, Javier; Delgado, Rafael; Martín León, NazarioAfter the last epidemic of the Zika virus (ZIKV) in Brazil that peaked in 2016, growing evidence has been demonstrated of the link between this teratogenic flavivirus and microcephaly cases. However, no vaccine or antiviral drug has been approved yet. ZIKV and Dengue viruses (DENV) entry to the host cell takes place through several receptors, including dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN), so that the blockade of this receptor through multivalent glycoconjugates supposes a promising biological target to inhibit the infection process. In order to get enhanced multivalency in biocompatible systems, tridecafullerenes appended with up to 360 1,2-mannobiosides have been synthesized using a strain-promoted cycloaddition of azides to alkynes (SPAAC) strategy. These systems have been tested against ZIKV and DENV infection, showing an outstanding activity in the picomolar range.- Project number: 316
Item Laboratorio virtual de Química Orgánica básica (Grado en Química, Doble Grado en Química y Bioquímica, Grado en Ingeniería Química)(2024) Illescas Martínez, Beatriz María; Martínez Ruiz, Mª Paloma; Vazquez Villa, Henar; Luna Costales, Amparo; Lora Maroto, Beatriz; Gómez Aspe, Rafael; Rodríguez Yunta, Mª Josefa; Descalzo López, Ana Belén; Alonso Gómez, José Miguel; Nieto Ortiz, Gema; Patino Alonso, Jennifer; Serrano Buitrago, Sergio; Fernández Cabellos, Daniel; González Jiménez, Marta; Sánchez Merino, Anabel; Reviejo Martínez, Eva; Bravo Muñoz, Ester; Calderón Saturio, Delia; García Matesanz, Diego; Illescas Martínez, Beatriz María