Person: Montero Solís, Eduardo
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First Name
Eduardo
Last Name
Montero Solís
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Odontología
Department
Especialidades Clínicas Odontológicas
Area
Estomatología
Identifiers
6 results
Search Results
Now showing 1 - 6 of 6
Item Surgical approach combining implantoplasty and reconstructivetherapy with locally delivered antibiotic in the treatment ofperi-implantitis: A prospective clinical case series(Clin Implant Dent Relat Res = Clinical Implant Dentistry and Related Research, 2021) González Regueiro, Iria; Martínez Rodriguez, Natalia; Barona Dorado, Cristina; Sanz Sánchez, Ignacio; Montero Solís, Eduardo; Ata-Ali, Javier; Duarte, Fernando; Martínez González, José MaríaBackground: Nonsurgical treatment, resective surgery, reconstructive surgery, or combined approaches have been proposed for the treatment of peri-implantitis, with variable results. Purpose: To evaluate the 1-year clinical and radiographic outcomes following combined resective and reconstructive surgical treatment with topical piperacillin/tazobactam antibiotic in the management of peri-implantitis. Material and methods: Forty-three patients diagnosed with peri-implantitis were included. Surgical treatment consisted of implantoplasty of the supra-crestal component of the defect, the application of a topical antibiotic solution over the implant surface, and subsequent reconstruction of the intra-osseous component of the peri-implant defect. The primary outcome was disease resolution, defined as the absence of bleeding on probing (BoP) and/or suppuration on probing (SoP), a peri-implant pocket probing depth (PPD) ≤5 mm, and no bone loss >0.5 mm 1 year after surgery. Secondary outcomes included changes in BoP, PPD, SoP, and peri-implant marginal bone levels. One implant per patient was included in the analysis. Results: The treatment success rate of the 43 dental implants included in the study was 86% at 1 year after surgery. Mean PPD and BoP decreased from 6.41 ± 2.11 mm and 100% at baseline to 3.19 ± 0.99 mm (p < 0.001) and 14% (p < 0.001) at 1 year, respectively. SoP was significantly reduced from 48.8% at baseline to 0% 1 year after surgery (p < 0.001). Radiographically, a mean defect fill of 2.64 ± 1.59 mm was recorded (p < 0.001). Conclusions: The combination of a resective and reconstructive surgical approach together with locally delivered antibiotic achieved a high disease resolution rate after 1 year of follow-up and constitutes a viable option for the management of peri-implantitis.Item Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial(Journal of clinical periodontology, 2012) Iniesta Albentosa, Margarita Isabel; Herrera González, David; Montero Solís, Eduardo; Zurbriggen, Milena; Matos, Ana ; Marín Cuenda, María José; Sánchez Beltrán, María Del Carmen; Llama Palacios, María Arantxazu; Sanz Alonso, MarianoObjective: To investigate the effects of an orally administered probiotic on the oral microbiota. Methods: A placebo-controlled, parallel study was conducted in 40 gingivitis subjects during 8 weeks. Treatment consisted on the administration of a daily tablet, either containing Lactobacillus reuteri or placebo. Unstimulated saliva and subgingival samples were collected and analysed by culture and PCR. Clinical and microbiological outcome variables were compared between and within groups. Results: There were no significant changes between and within the groups in the clinical variables. In saliva, total anaerobic counts after 4 weeks (p = 0.021) and counts of Prevotella intermedia after 8 weeks (p = 0.030), showed reductions in the test group. In subgingival samples, significant reductions in the changes baseline to 4 weeks were observed for P. gingivalis counts (p = 0.008). With PCR, L. reuteri ATCC-PTA-5289 was more frequently detected than L. reuteri DSM-17938. Conclusions: The effect of L. reuteri administered in tablets resulted in a reduction in the number of selected periodontal pathogens in the subgingival microbiota, without an associated clinical impact.Item Cardiometabolic risk factors and periodontitis: association and preventive and therapeutic implications(2021) Montero Solís, Eduardo; Herrera González, David; Sanz Alonso, MarianoPeriodontitis has been linked to several systemic diseases, most notably diabetes, for which a clear two-way association has been established. However, whether periodontitis is associated with other metabolic conditions, such as metabolic syndrome (MetS), or with other pre-diabetic hyperglycemic states, such as prediabetes, remains questionable. There is scarce evidence from intervention studies to elucidate if periodontal treatment could reduce the cardiovascular risk in patients with MetS. Furthermore, given the relationship between periodontitis and glycemic control, early detection of both conditions could have a positive impact on their prevention and management. Objectives: The general objective was to evaluate the association between periodontitis and DM and MetS, and in light of this association, to evaluate the positive global synergistic effects of preventive and/or therapeutic strategies aimed at their early diagnosis or management of these diseases. The specific objectives were: (i) to study the association between periodontitis, hyperglycemia (prediabetes and diabetes mellitus) and MetS in a representative sample of the Spanish employed population (Studies #1 and #2); (ii) to determine whether the treatment of periodontitis in patients with MetS could reduce their cardiometabolic risk (Study #3); to develop and validate a predictive model for moderate-to-severe periodontitis using a combination of cardio‐metabolic and socio‐demographic variables (Study #4); to evaluate the efficacy of different protocols for the detection of undiagnosed diabetes or prediabetes in a network of dental clinics (Study #5)...Item Periodontal diseases and depression: A pre‐clinical in vivo study(Journal of Clinical Periodontology, 2021) Martínez, María; Martín‐Hernández, David; Virto Ruiz, Leire; Mac-Dowell Mata, Karina Soledad; Leza Cerro, Juan Carlos; García Bueno, Borja; Figuero Ruiz, Elena; Ambrosio Elejalde, Nagore; Herrera González, David; Montero Solís, Eduardo; González Bris, Álvaro; Marín Cuenda, María José; Sanz Martín, MarianoAim: To analyse, through a pre-clinical in vivo model, the possible mechanisms linking depression and periodontitis at behavioural, microbiological and molecular levels. Materials and methods: Periodontitis (P) was induced in Wistar:Han rats (oral gavages with Porphyromonas gingivalis and Fusobacterium nucleatum) during 12 weeks, followed by a 3-week period of Chronic Mild Stress (CMS) induction. Four groups (n = 12 rats/group) were obtained: periodontitis and CMS (P+CMS+); periodontitis without CMS; CMS without periodontitis; and control. Periodontal clinical variables, alveolar bone levels (ABL), depressive-like behaviour, microbial counts and expression of inflammatory mediators in plasma and brain frontal cortex (FC), were measured. ANOVA tests were applied. Results: The highest values for ABL occurred in the P+CMS+ group, which also presented the highest expression of pro-inflammatory mediators (TNF-α, IL-1β and NF-kB) in frontal cortex, related to the lipoprotein APOA1-mediated transport of bacterial lipopolysaccharide to the brain and the detection of F. nucleatum in the brain parenchyma. A dysregulation of the hypothalamic-pituitary-adrenal stress axis, reflected by the increase in plasma corticosterone and glucocorticoid receptor levels in FC, was also found in this group. Conclusions: Neuroinflammation induced by F. nucleatum (through a leaky mouth) might act as the linking mechanism between periodontal diseases and depression.Item Evaluation of new chlorhexidineand cetylpyridinium chloride-based mouthrinse formulations adjunctive to scaling and root planing: pilot study(International Journal of Dental Hygiene, 2017) García-Gargallo, M; Zurlohe, Martina; Montero Solís, Eduardo; Alonso Álvarez, Bettina María; Serrano, Jorge; Sanz Alonso, Mariano; Herrera González, DavidObjective: To compare the effect of two newly formulated chlorhexidine (CHX) and cetylpyridinium chloride (CPC) mouthrinses after scaling and root planing (SRP) in terms of clinical, microbiological, patient-based variables and adverse events, with a positive control with the same active components, already marketed and tested. Methods: A pilot, randomized clinical trial, double-blind, parallel design with 1-month follow-up was conducted. Chronic periodontitis patients requiring non-surgical periodontal therapy were enrolled and randomly assigned to: (i) SRP and test-1 (new reformulation: 0.12% CHX and 0.05% CPC); (ii) SRP and test-2 (new formulation: 0.03% CHX and 0.05% CPC); or (iii) SRP and positive control (commercial product: 0.12% CHX and 0.05% CPC). All variables were evaluated at baseline and 1 month after SRP. Quantitative variables were compared by means of anova or Kruskal-Wallis test and qualitative variables by chi-square or McNemar tests. Results: Thirty patients (10 per group) were included. After 1 month, there were significant differences among groups in plaque levels (P = 0.016) as test-1 showed less sites with plaque than test-2 (31.15% [standard error-SE 2.21%] versus 49.39% [SE 4.60%), respectively). No significant differences were found for global patient perception of the product or in adverse effects. Test groups showed better results in levels and proportions (P = 0.022) of Capnocytophaga spp. Conclusions: Within the limitations of this pilot study, it can be concluded that the newly formulated 0.12% CHX and 0.05% CPC mouthrinse showed larger plaque level reductions, without showing more adverse effects, when compared to the other two mouthrinses, after SRP.Item Impact of periodontal therapy on systemic markers of inflammation in patients with metabolic syndrome: a randomized clinical trial(Diabetes, Obesity and Metabolism: A Journal of Pharmacology and Therapeutics, 2020) Montero Solís, Eduardo; López Durán, Mercedes; Vidal, Honorato; Martínez Ferrero, María; Virto Ruiz, Leire; Marrero, Jorge; Herrera González, David; Zapatero, Antonio; Sanz Alonso, MarianoAim: To determine the impact of periodontal treatment on systemic markers of inflammation in patients with metabolic syndrome (MetS) and periodontitis. Materials and methods: In this parallel-arm, double-blind, randomized controlled clinical trial, 63 patients with MetS and severe periodontitis were randomly assigned to receive either intensive periodontal treatment (IPT; scaling and root planing plus azithromycin 500 mg every day for 3 days) or minimal periodontal treatment (MPT; supragingival professional mechanical plaque removal plus a placebo). The primary outcome was the impact of the tested interventions on high-sensitivity C-reactive protein (hs-CRP) serum levels at 6 months. As secondary outcomes, differences in the levels of cytokines, markers of prothrombotic states, carbohydrate and lipid metabolism, as well as blood pressure, were measured at 3 and 6 months after therapy. Results: The intention-to-treat population consisted of 63 subjects randomly assigned to either the MPT (n = 31) or the IPT (n = 32) group. At baseline, mean hs-CRP was 3.9 mg/L (standard deviation [SD] = 2.9) and 3.9 mg/L (SD = 3.4), respectively, and no significant differences in cardiometabolic risk profiles were detected between the groups. Adjusting for baseline hs-CRP, sex, age, smoking status and body mass index, hs-CRP at 6 months was 1.2 mg/L (95% CI 0.4; 2.0; P = .004) lower in the IPT group than in the MPT group. In the secondary outcomes, significant reductions in IL-1β, TNF-α, HbA1c and blood pressure were observed in the IPT group at 3 months compared with the MPT group. Conclusion: Effective periodontal treatment significantly reduced hs-CRP after 6 months in patients with MetS and severe periodontitis. Periodontal therapy might be useful to reduce cardiovascular risk in these patients.