Person: Vázquez Osorio, María Teresa
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First Name
María Teresa
Last Name
Vázquez Osorio
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Anatomía y Embriología
Area
Anatomía y Embriología Humana
Identifiers
6 results
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Now showing 1 - 6 of 6
Item Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD)(Biomedicines, 2021) Estévez-Vázquez, Olga; Benedé-Ubieto, Raquel; Guo, Feifei; Gómez-Santos, Beatriz; Aspichueta, Patricia; Reissing, Johanna; Bruns, Tony; Sanz-García, Carlos; Sydor, Svenja; Bechmann, Lars P; Maranillo Alcaide, Eva; Sañudo Tejero, José Ramón; Vázquez Osorio, María Teresa; Lamas-Paz, Arantza; Morán, Laura; Mazariegos, Marina S; Ciudin, Andreea; Pericàs, Juan M.; Peligros, María Isabel; Vaquero, Javier; Martínez-Naves, Eduardo; Liedtke, Christian; Regueiro González-Barros, José Ramón; Trautwein, Christian; Bañares Cañizares, Rafael; Cubero Palero, Francisco Javier; Nevzorova, Yulia A.Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD). Methods: C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD—low concentration of PA (main fat source—corn and soybean oils); 2. HP-WD—high concentration of PA (main fat source—palm oil); 3. HP-Trans-WD—high concentration of PA (mainly transfat). Results: All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups. Conclusions: HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD.- Project number: 132
Item Elaboración de un manual de casos clínicos de anatomía radiológica aplicada de la extremidad inferior(2023) Aragonés Maza, Paloma; Maranillo Alcaide, Eva; Quiñones Garrido, Sara; Rodríguez Vázquez, José Francisco; Sañudo Tejero, José Ramón; Valderrama Canales, Francisco José; Vázquez Osorio, María Teresa; Viejo Tirado, Fermín Item The carotid axis revisited(Scientific reports, 2021) Cobiella, R; Quinones, S; Konschake, Marko; Aragonés Maza, Paloma; Leon Vintró, Xavier; Vázquez Osorio, María Teresa; Sañudo Tejero, José Ramón; Maranillo Alcaide, EvaThe aim was to determine the variations in the level of origin of carotid bifurcation and diameters of the common, internal, and external carotid arteries which is clinically important for several interventional procedures. Therefore, 165 human embalmed corpses were dissected. The data collected were analyzed using the Chi square-test and the Pearson correlation test. The results of previous studies have been reviewed. In relation to the level of the carotid bifurcation, taking as a reference point the hyoid bone, the values ranged from 4 cm below the hyoid body to 2.5 cm above the body of the hyoid, being the average height—0.33 cm, with a standard deviation of 1.19 cm. The right carotid bifurcation was established at a higher level (x = − 0.19 cm.) than the left one (x = − 0.48 cm.) (p = 0.046). On the contrary, no significant gender differences could be observed. The arterial calibres of the common and internal carotid arteries were higher in male than female. In the internal carotid artery (X = 0.76 cm.), the left was greater than the right (X = 0.72 cm.) (P = 0.047). However, no differences in the distribution of the calibre of the external carotid artery were found neither by side nor gender. Variations in the level of bifurcation and calibres of carotid arteries are relevant for interventional radiology procedures and head and neck surgeries. Knowledge of these anatomical references might help clinicians in the interpretation of the carotid system.Item Practical postgraduate teaching in Human Anatomy: A review(European Journal of Anatomy, 2021) Sañudo Tejero, José Ramón; Vázquez Osorio, María Teresa; Talarico Jr., Ernest F.; Duparc, Fabrice; Paulsen, Friedrich; Macchi, Verónica; Feigl, George; Elizondo-Omaña,Rodrigo; Caro, Raffaele De; Aragonés, P.; McHanwell, Stephen; Morigg, Bernhard; Konschake, MarkoAnatomy is a fundamental subject for both medical and surgical training. Anatomy departments might collaborate with clinicians organizing continuing medical education (CME) and other professional development courses. The courses should have a large practical component (in content and organization) but also should provide the latest scientifically based theoretical knowledge, respecting the learning of anatomy as well as aiming at performing different techniques. Anatomy departments should support these courses by establishing hands-on practical training courses and componentsItem Fat: quality or quantity? What matters most for the progression of Metabolic Associated Fatty Liver Disease (MAFLD).(Biomedicines, 2021) Estévez Vázquez, Olga; Benede Ubieto, Raquel; Sanz García, Carlos; Maranillo Alcaide, Eva; Sañudo Tejero, José Ramón; Vázquez Osorio, María Teresa; Lamas Paz, Arantza; Peligros Gómez, María Isabel; Vaquero, Javier; Martínez Naves, Eduardo; Regueiro González-Barros, José Ramónfirst_pagesettingsOrder Article Reprints Open AccessArticle Fat: Quality, or Quantity? What Matters Most for the Progression of Metabolic Associated Fatty Liver Disease (MAFLD) by Olga Estévez-Vázquez 1,2ORCID,Raquel Benedé-Ubieto 1,2,Feifei Guo 2,Beatriz Gómez-Santos 3ORCID,Patricia Aspichueta 3,4,5ORCID,Johanna Reissing 6,Tony Bruns 6ORCID,Carlos Sanz-García 2ORCID,Svenja Sydor 7ORCID,Lars P. Bechmann 7,Eva Maranillo 8,José Ramón Sañudo 8,María Teresa Vázquez 8,Arantza Lamas-Paz 2ORCID,Laura Morán 2,9,Marina S. Mazariegos 2,Andreea Ciudin 10ORCID,Juan M. Pericàs 5,11,María Isabel Peligros 12,Javier Vaquero 5,9,13ORCID,add Show full author list 1 Department of Physiology, Genetics and Microbiology, Faculty of Biology, Complutense University of Madrid, 28040 Madrid, Spain 2 Department of Immunology, Ophthalmology and ENT, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain 3 Department of Physiology, Faculty of Medicine and Nursing, University of Basque Country UPV/EHU, 48940 Leioa, Spain 4 Biocruces Health Research Institute, 48903 Barakaldo, Spain 5 Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Instituto de Salud Carlos III, 28220 Madrid, Spain 6 Department of Internal Medicine III, University Hospital RWTH Aachen, 52074 Aachen, Germany 7 Department of Internal Medicine, University Hospital Knappschaftskrankenhaus, Ruhr-University Bochum, 44801 Bochum, Germany 8 Department of Human Anatomy and Embryology, School of Medicine, Complutense University of Madrid, 28040 Madrid, Spain 9 Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), 28009 Madrid, Spain 10 Endocrinology Department, Vall d’Hebron University Hospital, Vall d’Hebron Institute for Research (VHIR), 08035 Barcelona, Spain add Show full affiliation list * Author to whom correspondence should be addressed. † These authors contributed equally to this work. Biomedicines 2021, 9(10), 1289; https://doi.org/10.3390/biomedicines9101289 Submission received: 12 August 2021 / Revised: 13 September 2021 / Accepted: 19 September 2021 / Published: 22 September 2021 (This article belongs to the Special Issue Metabolic Syndrome and NASH: From Molecular Basis to Therapy) Downloadkeyboard_arrow_down Browse Figures Review Reports Versions Notes Abstract Objectives: Lately, many countries have restricted or even banned transfat, and palm oil has become a preferred replacement for food manufacturers. Whether palm oil is potentially an unhealthy food mainly due to its high content of saturated Palmitic Acid (PA) is a matter of debate. The aim of this study was to test whether qualitative aspects of diet such as levels of PA and the fat source are risk factors for Metabolic Syndrome (MS) and Metabolic Associated Fatty Liver Disease (MAFLD). Methods: C57BL/6 male mice were fed for 14 weeks with three types of Western diet (WD): 1. LP-WD—low concentration of PA (main fat source—corn and soybean oils); 2. HP-WD—high concentration of PA (main fat source—palm oil); 3. HP-Trans-WD—high concentration of PA (mainly transfat). Results: All types of WD caused weight gain, adipocyte enlargement, hepatomegaly, lipid metabolism alterations, and steatohepatitis. Feeding with HP diets led to more prominent obesity, hypercholesterolemia, stronger hepatic injury, and fibrosis. Only the feeding with HP-Trans-WD resulted in glucose intolerance and elevation of serum transaminases. Brief withdrawal of WDs reversed MS and signs of MAFLD. However, mild hepatic inflammation was still detectable in HP groups. Conclusions: HP and HP-Trans-WD play a crucial role in the genesis of MS and MAFLD.Item Clinical anatomy of the lumbar sinuvertebral nerve with regard to discogenic low back pain and review of literature(European Spine Journal, 2021) Quinones, Sara; Aragonés Maza, Paloma; Bouzada, J.; Valderrama Canales, Francisco José; Vázquez Osorio, María Teresa; Sañudo Tejero, José RamónPurpose: Lumbar discogenic diffuse pain is still not understood. Authors describe the sinuvertebral nerve (SVN) as one possible cause. Body-donor studies are rare and controversial. Therefore, the aim was to revisit the origin, course and distribution in a body-donor study. Methods: Six lumbar blocks (3 female, 3 male) aged between 59 and 94 years were dissected. After removal of the back muscles, lamina, dura mater and cauda equina, the anterior vertebral venous plexus, spinal artery and SVN were exposed and evaluated. Results: 43 nerves out of 48 levels could be evaluated. The origin of the SVN was constituted by two roots: a somatic and a sympathetic branch arising from the rami communicantes. In 4/48 intervertebral canals studied (8.3%), we found two SVN at the same level. In 35/48 cases, one SVN was found. In 9/48 cases, no SVN was found. The SVN had a recurrent course below the inferior vertebral notch; in the vertebral canal it showed different patterns: ascending branch (31/43, 72.1%), common branch diverging into two branches (10/43, 23.3%), double ascending branch (1/43, 2.3%) finalizing two levels above and a descending branch (1/43, 2.3%). In 12/43 cases (27.9%) the SVN had ipsilateral connections with another SVN. The distribution ended in the middle of the vertebral body supplying adjacent structures. Conclusion: A thorough understanding of the anatomy of the SVN might lead to significant benefits in therapy of discogenic low back pain. We suggest blocking the SVN at the level of the inferior vertebral notch of two adjacent segments. Level of evidence I: Diagnostic: individual cross-sectional studies with consistently applied reference standard and blinding