Person:
Sanz Ortega, Julián

Profile Picture
First Name
Julián
Last Name
Sanz Ortega
URI
https://hdl.handle.net/20.500.14352/79705
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Medicina
Department
Area
Anatomía Patológica
Identifiers
UCM identifierScopus Author IDDialnet ID

Filters

2019 - 201912020 - 20211
Reset filters

Settings

Search Results

Now showing 1 - 2 of 2
  • Thumbnail Image
    Item
    Project number: 146
    Incorporación del arte en la enseñanza de la Medicina
    (2021) Pelayo Alarcón, Adela; Ortega medina, Luis; López-Ibor Alcocer, María Inés; Blanco Caneda, Maria Luisa; Polo Gaitan, Maria Gracia; Diaz Mata, Leticia; Casado Fariñas, Maria Isabel; Pascual Martin, Alejandro; Saiz-Pardo Sanz, Melchor; Zamarro Sanz, María Luisa; González Morales, María Luisa; Sanz Ortega, Julián
    Mediante el estudio y análisis de obras de arte que manifiestan temas relacionados con la Medicina queremos enseñar al estudiante a observar y percibir, desarrollar el análisis critico, plantearse diagnósticos diferenciales en suma ejercer la medicina con mayor éxito. El análisis de estas obras de arte les ha permitido también tener una perspectiva histórica de la Medicina, enriquecer su formación humanística, aumentar la creatividad, el juicio critico y el trabajo en equipo.
  • Thumbnail Image
    Item
    c-Met Signaling Is Essential for Mouse Adult Liver Progenitor Cells Expansion After Transforming Growth Factor-β-Induced Epithelial–Mesenchymal Transition and Regulates Cell Phenotypic Switch
    (Stem Cells, 2019) Almale Del Barrio, Laura; García-Álvaro, María; Martínez-Palacián, Adoración; García-Bravo, María; Lazcanoiturburu, Nerea; Addante, Annalisa; Roncero Romero, Cesáreo; Sanz Ortega, Julián; López, María de la O; Bragado Domingo, Paloma; Mikulits, Wolfgang; Factor, Valentina M.; Thorgeirsson, Snorri S.; Ignacio, Casal, J.; Segovia, José-Carlos; Rial, Eduardo; Fabregat Romero, María Isabel; Herrera González, Blanca María; Sánchez Muñoz, Aranzazu
    Adult hepatic progenitor cells (HPCs)/oval cells are bipotential progenitors that participate in liver repair responses upon chronic injury. Recent findings highlight HPCs plasticity and importance of the HPCs niche signals to determine their fate during the regenerative process, favoring either fibrogenesis or damage resolution. Transforming growth factor-β (TGF-β) and hepatocyte growth factor (HGF) are among the key signals involved in liver regeneration and as component of HPCs niche regulates HPCs biology. Here, we characterize the TGF-β-triggered epithelial–mesenchymal transition (EMT) response in oval cells, its effects on cell fate in vivo, and the regulatory effect of the HGF/c-Met signaling. Our data show that chronic treatment with TGF-β triggers a partial EMT in oval cells based on coexpression of epithelial and mesenchymal markers. The phenotypic and functional profiling indicates that TGF-β-induced EMT is not associated with stemness but rather represents a step forward along hepatic lineage. This phenotypic transition confers advantageous traits to HPCs including survival, migratory/invasive and metabolic benefit, overall enhancing the regenerative potential of oval cells upon transplantation into a carbon tetrachloride-damaged liver. We further uncover a key contribution of the HGF/c-Met pathway to modulate the TGF-β-mediated EMT response. It allows oval cells expansion after EMT by controlling oxidative stress and apoptosis, likely via Twist regulation, and it counterbalances EMT by maintaining epithelial properties. Our work provides evidence that a coordinated and balanced action of TGF-β and HGF are critical for achievement of the optimal regenerative potential of HPCs, opening new therapeutic perspectives.