Person: Yubero Pancorbo, Raquel
Loading...
First Name
Raquel
Last Name
Yubero Pancorbo
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Psicología
Department
Area
Psicología Básica
Identifiers
3 results
Search Results
Now showing 1 - 3 of 3
Item The Impact of the Eye in Dementia: The Eye and its Role in Diagnosis and Follow‐up(Update on Dementia, 2016) García Martín, Elena Salobrar; Ramírez Sebastián, Ana Isabel; Hoz Montañana, Rosa de; Rojas, Pilar; Salazar Corral, Juan José; Rojas López, Blanca; Yubero Pancorbo, Raquel; Gil, Pedro; Triviño Casado, Alberto; Ramirez Sebastian, Jose Manuel; Moretti, DavidOver the last few decades, the importance of ophthalmic examination in neurodegenerative diseases of the CNS has reportedly increased. The retina is an extension of the CNS and thus should not be surprising to find abnormal results in both the test exploring visual processing and those examining the retina of patients with CNS degeneration. Current in vivo imaging techniques are allowing ophthalmologists to detect and quantify data consistent with the histopathological findings described in the retinas of Alzheimer’s disease (AD) patients and may help to reveal unsuspected retinal and optic‐nerve repercussions of other CNS diseases. In this chapter, we perform an analysis of the physiological changes in ocular and cerebral ageing. We analyse the ocular manifestations in CNS disorders such as stroke, AD and Parkinson’s disease. In addition, the pathophysiology of both the eye and the visual pathway in AD are described. The value of the visual psychophysical tests in AD diagnosis is reviewed as well as the main findings of the optical coherence tomography as a contribution to the diagnosis and monitoring of the disease. Finally, we examine the association of two neurodegenerative diseases, AD and glaucoma, as mere coincidence or possible role in the progression of the neurodegeneration.Item Macular Thickness as a Potential Biomarker of Mild Alzheimer's Disease(Ophthalmology, 2014) García Martín, Elena Salobrar; Rojas López, Blanca; Ramírez Sebastián, Ana Isabel; Hoz Montañana, Rosa de; Salazar Corral, Juan José; Yubero Pancorbo, Raquel; Gil, Pedro; Triviño Casado, Alberto; Ramirez Sebastian, Jose ManuelAlthough several postmortem findings in the retina of patients with Alzheimer's disease (AD) are available, new biomarkers for early diagnosis and follow-up of AD are still lacking. It has been postulated that the defects in the retinal nerve fiber layer (RNFL) may be the earliest sign of AD, even before damage to the hippocampal region that affects memory. This fact may reflect retinal neuronal-ganglion cell death and axonal loss in the optic nerve in addition to aging.Item Ophthalmologic Psychophysical Tests Support OCT Findings in Mild Alzheimer's Disease(Journal of Ophthalmology, 2015) García Martín, Elena Salobrar; Hoz Montañana, María Rosa de; Rojas López, María Blanca; Ramírez Sebastián, Ana Isabel; Salazar Corral, Juan José; Yubero Pancorbo, Raquel; Gil Gregorio, Pedro; Triviño Casado, Alberto; Ramirez Sebastian, Jose ManuelPurpose. To analyze in mild Alzheimer's disease (MAD) patients, GDS-4 (Reisberg Scale), whether or not some psychophysical tests (PTs) support OCT macular findings in the same group of MAD patients reported previously. Methods. Twenty-three MAD patients and 28 age-matched control subjects with mean Mini Mental State Examination of 23.3 and 28.2, respectively, with no ocular disease or systemic disorders affecting vision were included. Best-corrected visual acuity (VA), contrast sensitivity (CS) (3, 6, 12, and 18 cpds), color perception (CP), and perception digital test (PDT) were tested in one eye of each patient. Results. In comparison with the controls, MAD patients presented (i) a significant decrease in VA, PDT, and CS for all spatial frequencies analyzed, especially the higher ones, and (ii) a significant increase in unspecific errors on the blue axis (P < 0.05 in all instances). In MAD patients, a wide a ROC curve was plotted in all PTs. Conclusions. In MAD, CS, VA, and the tritan axis in CP were impaired. The PTs with the greatest predictive value are the higher spatial frequencies in CS and tritan unspecific errors in CP. PT abnormalities are consistent with the structural findings reported in the same MAD patients using OCT.