Person:
Serrano Valle, Julia

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First Name
Julia
Last Name
Serrano Valle
URI
https://hdl.handle.net/20.500.14352/81663
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Odontología
Department
Especialidades Clínicas Odontológicas
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Author: Hernández Vallejo, Gonzalo × Subject: 616.314 ×

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    Short‐term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri‐implant mucositis: A double‐blind, randomized, clinical trial
    (Journal of Periodontal Research, 2021) González Serrano, José; López-Pintor Muñoz, Rosa María; Serrano Valle, Julia; Torres García Denche, Jesús; Hernández Vallejo, Gonzalo; Sanz Martín, Mariano
    Objective: To determine the efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E as adjuvant to mechanical debridement in the treatment of peri- implant mucositis (PM). Background: Propolis has anti-inflammatory and antibacterial effect that may im- prove peri-implant health. Methods: A randomized, double-blind study was performed on patients with at least one implant with PM. Participants received a professional prophylaxis and were in- structed to use either test or a control gel as toothpaste three times/day for 1 month. Clinical and microbiological parameters were evaluated. PM resolution was considered in absence of bleeding on probing (BOP). Data were analysed with Mann-Whitney U, Wilcoxon signed-rank and chi-square tests. Results: Forty-six patients participated (23 in each group). After treatment, 26.1% of test patients showed complete PM resolution versus 0% in control group (p = .02). Significant reductions were observed in plaque index (p = .03), BOP (p = .04) and prob- ing depths (p = .027) in test compared with control group. The reduction in Tannerella forsythia was statistically greater in test than in control group at 1-month follow-up (p = .02). Porphyromonas gingivalis was statistically reduced in test group from baseline to 1-month follow-up (p = .05). Conclusion: Test gel clinically improved PM and showed certain antimicrobial effect after 1 month in comparison with control group. Further long-term clinical trials are required to confirm these results.