Person:
Serrano Valle, Julia

First Name

Julia

Last Name

Serrano Valle

URI

https://hdl.handle.net/20.500.14352/81663

Affiliation

Universidad Complutense de Madrid

Faculty / Institute

Odontología

Department

Especialidades Clínicas Odontológicas

Identifiers

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Now showing 1 - 10 of 12

Project number: 281
Enseñanza no presencial de la asignatura patología bucal a través de la presentación de artículos científicos en inglés
(2018) López-Pintor Muñoz, Rosa María; Hernández Vallejo, Gonzalo; de Arriba de la Fuente, Lorenzo; Casañas Gil, Elizabeth; Ramírez Martínez-Acitores, Lucía; Serrano Valle, Julia; de Pedro Herráez, Miguel
Elaboración de un dossier de artículos en Inglés en relación a cada unidad temática de la asignatura Patología Médica Bucal. Los artículos se presentarán al alumnado tras la clase magistral de cada área temática para fomentar la docencia “no presencial”.
Project number: 195
Realización de folletos informativos acerca de la patología de la mucosa oral para informar a pacientes y profesionales sanitarios
(2019) López-Pintor Muñoz, Rosa María; Hernández Vallejo, Gonzalo; Arriba de la Fuente, Lorenzo de; Somacarrera Pérez, María Luisa; López Sánchez, Antonio Francisco; González Serrano, José; Casañas Gil, Elizabeth; Ramírez Martínez-Acitores, Lucía; Serrano Valle, Julia; Pedro Herráez, Miguel de
Elaboración de folletos informativos acerca de la patología de la mucosa oral más relevante para informar a pacientes y colectivos médico-sanitarios. El trabajo será realizado por los alumnos de la asignatura Patología Médica Bucal de tercer curso de Odontología. Los trípticos se realizarán para fomentar la docencia “no presencial” y el tipo de trabajo será de aprendizaje por proyectos. Este trabajo comprometerá al alumno emocional y afectivamente con su aprendizaje ya que ayudará a diagnosticar y tratar de forma temprana dichas patologías. Los alumnos de la asignatura Medicina Bucal realizarán folletos acerca de la Patología de la Mucosa Oral para informar a pacientes y colectivos sanitarios. Se fomentará la docencia no presencial, el tipo de trabajo será de aprendizaje por proyectos
Efficacy and safety of a bioadhesive gel containing propolis extract, nanovitamin C and nanovitamin E on desquamative gingivitis: a double‑blind, randomized, clinical trial
(Clinical Oral Investigations, 2022) González Serrano, José; Serrano Valle, Julia; Sanz Alonso, Mariano; Torres García-Denche, Jesús; Hernández Vallejo, Gonzalo; López-Pintor Muñoz, Rosa María
Objectives: To evaluate the efcacy of a gel-containing propolis extract, nanovitamin C, and nanovitamin E as adjuvants to professional plaque removal on desquamative gingivitis (DG). Materials and methods: A randomized clinical trial was conducted on patients sufering DG due to mucocutaneous diseases. Patients received professional supragingival prophylaxis with oral hygiene instructions and were randomly assigned to use test or control gels as toothpaste and to apply it on DG lesions 3 times/day for 4 weeks. DG clinical score (DGCS), clinical periodontal variables, and visual analog scale (VAS) for pain and oral health impact profle (OHIP-14) were collected at baseline, 2 and 4 weeks. Results: Twenty-two patients were randomly assigned to test (n=11) or control group (n=11). Eighteen had diagnosis of oral lichen planus and four of mucous membrane pemphigoid. DGCS statistically decreased in both groups after treatment with no signifcant diferences between groups. Clinical periodontal outcomes decreased in both groups, but no signifcant diferences were observed. Periodontal variables statistically improved only in test group after treatment. VAS and OHIP-14 scores decreased in test and control groups without signifcant diferences. However, only one test group showed a statistically signifcant decrease in VAS and OHIP-14 scores after treatment. No adverse efects were reported. Conclusions: Test gel may alleviate DG and improve quality of life without side efects. Clinical relevance: A gel-containing propolis extract, nanovitamin C, and nanovitamin E as adjuvants to mechanical debridement may improve both clinical and patient related outcomes in DG patients without side efects. Clinical trial registration. The study protocol was registered at clinicaltrials.gov with the following number: NCT05124366 on October 16, 2021.
Usefulness of implementing the OHIP-14 questionnaire to assess the impact of xerostomia and hyposalivation on qualityof life in patients with primary Sjögren's syndrome
(Journal of Oral Pathology & Medicine, 2022) Serrano Valle, Julia; López-Pintor Muñoz, Rosa María; Fernández Castro, Mónica; Ramírez Martínez-Acitores, Lucía; Sanz Alonso, Mariano; López, Javier; Blázquez, María Angeles; González, Jorge Juan; Hernández Vallejo, Gonzalo
Background: The aim of this study is to analyze if the results of the Oral Health Impact Profile-14 questionnaire (OHIP-14) in patients with primary Sjögren's syndrome (pSS) are correlated with salivary flow and level of xerostomia. Methods: This observational cross-sectional study was conducted in 61 patients (60 women, one man, mean age 57.64 [13.52]) diagnosed of pSS according to the American-European Criteria (2002). After recording demographic, medical and dental data (decayed-missing-filled teeth index [DMFT]), unstimulated (UWS) and stimulated (SWS) salivary flows were collected. Subsequently, UWS flow was categorized into two groups (0.7 ml/min). Patients also filled out a visual analog scale (VAS) for xerostomia and OHIP-14 for self-reported quality of life (QoL). Results: Data showed positive and significant correlation between OHIP-14 and xerostomia, based on VAS results (r = 0.52; p = 0.001). Furthermore, there was a negative correlation between UWS and OHIP-14 scores (r = -0.34; p = 0.006) and VAS for xerostomia (r = -0.22; p = 0.09). No significant correlation was found between SWS and OHIP-14 or VAS neither between DMFT and OHIP-14. When assessing the level of QoL by the UWS and SWS flow categories a significant association was found for UWS (p = 0.001) but not for SWS (p = 0.11). The OHIP-14 values were higher in the groups with lower salivary flow. The multiple linear regression to predict OHIP-14 only selected VAS for xerostomia as a statistically significant predictor. Conclusions: Increased level of xerostomia and reduced UWS flow decrease oral health-related QoL in patients with pSS.
Project number: 159
Development of a program of mixed radiolucent-radiopaque lesions imaging via radiographic cases for active learning in oral medicine
(2017) López-Pintor Muñoz, Rosa María; Hernández Vallejo, Gonzalo; Ortega Aranegui, Ricardo; Paredes Rodríguez, Víctor Manuel; de Arriba de la Fuente, Lorenzo; Casañas Gil, Elisabeth; Ramírez Martínez-Acitores, Lucia; Serrano Valle, Julia
A través del presente proyecto se ha creado un fichero de imágenes radiográficas mixtas (radiopacas-radiolucidas) que serán utilizadas por los alumnos del tercer curso de Grado de la asignatura Medicina Bucal a fin de mejorar la enseñanza práctica del apartado lesiones radiográficas de los maxilares. Dichos ficheros se incorporarán al Campus Virtual para que el alumno pueda hacer uso de ellos. La elaboración de un fichero de estas características ha exigido en primer lugar la selección de las imágenes radiográficas mixtas de los maxilares más representativas. Se han seleccionado 43 imágenes radiográficas mixtas que se han clasificado en “Mixed Radiolucent-Radiopaque periapical lesions” (15 imágenes), “Mixed Radiolucent-Radiopaque pericoronal lesions” (8 imágenes) y “Mixed Radiolucent-Radiopaque lesions not necessarily contacting teeth“ ( 20 imágenes). Se han realizado 4 flowchart (el tercer grupo se subdividió en dos) para esquematizar las lesiones mixtas más frecuentes con sus características clínicas y radiográficas más habituales. Dichos flowchart ayudarán al alumno a poder llegar al diagnóstico de las lesiones de los casos clínicos seleccionados, cuya historia clínica también se ha reflejado. Todo el trabajo se ha realizado en dos idiomas inglés y español, que ayudará a los alumnos a aprender el vocabulario en inglés relacionado con el tema. Además, facilitará la comprensión de los alumnos de otras nacionalidades que pueden acudir a nuestra facultad y ayudará a los alumnos de la UCM que acuden a otras universidades Europeas o Americanas.
Lesiones orales en el paciente con síndrome de Sjögren primario
(2021) Serrano Valle, Julia; López-Pintor Muñoz, Rosa María; Hernández Vallejo, Gonzalo
El síndrome de Sjögren es una enfermedad sistémica, crónica y autoinmune que se caracteriza por un infiltrado linfocitario y una destrucción subsecuente de las glándulas exocrinas, lo que conlleva a una disminución del flujo lacrimal y salival. Su etiología es desconocida, aunque se considera de base multifactorial. Se clasifica en síndrome de Sjögren primario cuando aparece como una enfermedad aislada y secundario cuando dichas alteraciones se asocian a otras enfermedades autoinmunes como la artritis reumatoide, el lupus eritematoso sistémico o la esclerodermia. La evidencia científica acerca de las manifestaciones orales en el síndrome de Sjögren primario se ha centrado en estudiar la xerostomía e hiposialia, sin embargo, hay pocos datos acerca de la prevalencia, tipo y factores predisponentes de las lesiones de la mucosa oral. Hasta la fecha, no existía una visión global de cuáles eran las lesiones orales más comunes en estos pacientes ni si dichas lesiones aparecían con mayor frecuencia que en la población general. Del mismo modo no se habían estudiado los posibles factores de riesgo asociados a las mismas. Objetivos: El objetivo general de esta tesis doctoral es valorar la presencia de lesiones orales en los pacientes con síndrome de Sjögren primario. Los objetivos específicos son: realizar una revisión sistemática de la presencia de lesiones orales en pacientes con síndrome de Sjögren y compararlas (cuando estaba disponible) con un grupo control (estudio 1); comparar la presencia de lesiones orales en pacientes con síndrome de Sjögren primario respecto a un grupo control y estudiar los factores predisponentes para la aparición de dichas lesiones en estos pacientes (estudio 2); e investigar la asociación entre la presencia de Candida albicans y lesiones clínicas de candidiasis oral con los niveles de flujo y pH salival y determinar los factores de riesgo asociados a sufrir candidiasis oral en estos pacientes (estudio 3)...
Efficacy of antimalarials in oral lichen planus: a systematic review
(Oral diseases, 2024) Tillero, Rosana; González Serrano, José; Alberto Caponio, Vito Carlo; Serrano Valle, Julia; Hernández Vallejo, Gonzalo; López-Pintor Muñoz, Rosa María
Objective: To evaluate whether hydroxychloroquine (HCQ) or chloroquine (CQ) are effective for the treatment of oral lichen planus (OLP). Materials and methods: A literature search was conducted in four databases. Clinical studies investigating the effect of HCQ/CQ in patients with OLP were included. Results: Eleven studies were included. Four were RCTs and seven quasi-experimental studies. The studies included 390 patients diagnosed with OLP, of which 326 and 7 received HCQ and CQ, respectively. 46 patients received topical dexamethasone, 5 placebo and 6 griseofulvin as controls. Five studies assessed pain, and all of them obtained pain reduction with the use of HCQ. Six studies reported objective clinical improvement of OLP with the use of HCQ. Five studies that used a subjective scale obtained that 24%-100% of the patients achieved a complete/almost complete improvement of OLP lesions and its symptomatology. The most frequent side effects were vision problems, gastric discomfort, rash, nauseas, headaches, skin pigmentation, and elevated kidney function. 17 patients had to withdraw from the studies. Conclusions: Current evidence is scarce to confirm HCQ as a therapeutic option for OLP. More RCTs are needed to compare its efficacy with topical corticosteroids and to evaluate whether HCQ reduces relapses of OLP.
Association of salivary inflammatory biomarkers with primary Sjögren’s syndrome
(Journal of Oral Pathology and Medicine, 2020) Moreno-Quispe, Luz A; Serrano Valle, Julia; Virto Ruiz, Leire; Sanz Alonso, Mariano; Ramírez Sanz, Lucía; Fernández-Castro, Mónica; Hernández Vallejo, Gonzalo; López-Pintor Muñoz, Rosa María
Background: Primary Sjogren’s syndrome (pSS) is an autoimmune disease that leads to salivary and lacrimal gland dysfunction. The adaptive immune response associated with T helper-2 lymphocytes appears to be altered in these patients. Therefore, the objective of this study was to determine the salivary levels of IL-6, 5 and 4 in patients with pSS when compared to a healthy control (HC) group. The secondary objectives were to study whether ILs levels in pSS patients were associated with salivary flow, patient-reported outcomes (PROMs) for xerostomia and oral health quality of life (OHIP-14), pSS classification criteria and presence of extraglandular manifestations. Methods: A case-control study was conducted in 36 patients with pSS and 35 HCs. Cytokine levels were measured using high-sensitivity multiplex map human immunoassays. Unstimulated and stimulated whole saliva were collected and patients filled out the questionnaires. The U-Mann-Whitney test, chi-squared and Spearman correlation test were used. Results: IL-6 was significantly higher in pSS patients than in HCs (p=0.0001). IL-6 was significantly higher in pSS patients with a positive salivary gland biopsy (p=0.04), whole stimulated saliva hyposalivation (p=0.02) and presence of musculoskeletal disorders (p=0.03). There was a non-significant positive correlation between IL-6 levels and PROMs for xerostomia (r=0.31; p=0.06) and OHIP-14 (r=0.07; p=0.68) in pSS patients. Levels of IL4 and IL5 were not detected in both pSS and HCs patients. Conclusions: Salivary IL-6 levels were significantly associated with pSS patients and therefore, it is hypothesized that this biomarker may be useful in the diagnosis and follow-up of this disease.
Short‐term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri‐implant mucositis: A double‐blind, randomized, clinical trial
(Journal of Periodontal Research, 2021) González Serrano, José; López-Pintor Muñoz, Rosa María; Serrano Valle, Julia; Torres García Denche, Jesús; Hernández Vallejo, Gonzalo; Sanz Martín, Mariano
Objective: To determine the efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E as adjuvant to mechanical debridement in the treatment of peri- implant mucositis (PM). Background: Propolis has anti-inflammatory and antibacterial effect that may im- prove peri-implant health. Methods: A randomized, double-blind study was performed on patients with at least one implant with PM. Participants received a professional prophylaxis and were in- structed to use either test or a control gel as toothpaste three times/day for 1 month. Clinical and microbiological parameters were evaluated. PM resolution was considered in absence of bleeding on probing (BOP). Data were analysed with Mann-Whitney U, Wilcoxon signed-rank and chi-square tests. Results: Forty-six patients participated (23 in each group). After treatment, 26.1% of test patients showed complete PM resolution versus 0% in control group (p = .02). Significant reductions were observed in plaque index (p = .03), BOP (p = .04) and prob- ing depths (p = .027) in test compared with control group. The reduction in Tannerella forsythia was statistically greater in test than in control group at 1-month follow-up (p = .02). Porphyromonas gingivalis was statistically reduced in test group from baseline to 1-month follow-up (p = .05). Conclusion: Test gel clinically improved PM and showed certain antimicrobial effect after 1 month in comparison with control group. Further long-term clinical trials are required to confirm these results.
Xerostomia and Salivary Flow in Patients Taking Antihypertensive Drugs
(International Journal of Environmental Research and Public Health, 2020) Ramírez Martínez-Acitores, Lucía; Hernández Ruiz de Azcárate, Fernando; Casañas, Elisabeth; Serrano Valle, Julia; Hernández Vallejo, Gonzalo; López-Pintor Muñoz, Rosa María
The aims of this systematic review are (1) to compare the prevalence of xerostomia and hyposalivation between patients taking antihypertensive drugs with a control group (CG), (2) to compare salivary flow rate between patients treated with a CG, and (3) to identify which antihypertensives produce xerostomia. This systematic review was carried out according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. To evaluate methodological quality of the eligible studies Cochrane Collaboration tool for assessing the risk of bias for clinical trials and the modified Newcastle–Ottawa scale case-control studies were used. The databases were searched for studies up to November 19th 2019. The search strategy yielded 6201 results and 13 publications were finally included (five clinical trials and eight case-control studies). The results of the included studies did not provide evidence to state that patients taking antihypertensives suffer more xerostomia or hyposalivation than patients not taking them. With regard to salivary flow, only two clinical studies showed a significant decrease in salivary flow and even one showed a significant increase after treatment. The case–control studies showed great variability in salivary flow, but in this case most studies showed how salivary flow is lower in patients medicated with antihypertensive drugs. The great variability of antihypertensive drugs included, the types of studies and the outcomes collected made it impossible to study which antihypertensive drug produces more salivary alterations. The quality assessment showed how each of the studies was of low methodological quality. Therefore, future studies about this topic are necessary to confirm whether antihypertensive drugs produce salivary alterations.