Person: González Burgos, Elena María
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First Name
Elena María
Last Name
González Burgos
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Farmacia
Department
Farmacología, Farmacognosia y Botánica
Area
Farmacología
Identifiers
32 results
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Now showing 1 - 10 of 32
Item Identificación de problemas relacionados con el medicamento y estrategias de mejora en personas mayores(2020) Fernández Alfonso, María Soledad; Cea Soriano, Trinidad Lucia; Astasio Arbiza, Paloma; Bedoya del Olmo, Luis Miguel; Garcia Broncano, Rosario; García Ferrera, Alicia; García García, Luis; Garcimartín Álvarez, Alba; Gómez Oliver, Francisca; González Burgos, Elena María; Guerra Guirao, Jose Antonio; Manouchehri, Marjan; Manzano Lista, Francisco Javier; Ortega Molina, Paloma; Pulido Manzanero, José; Sánchez Ortíz, Sara; Santos Sancho, Juana- Project number: 249
Item Flipped Learning y Web App de Plantas Medicinales Nuevas estrategias educativas aplicadas al ámbito de la enseñanza en la asignatura de Farmacognosia y Fitoterapia(2017) Gómez-Serranillos Cuadrado, María Pilar; González Burgos, Elena María; Fernández Moriano, Carlos; Iglesias Peinado, Irene; Gavilán García, Rosario Gloria; Garcia Broncano, Rosario Item Climate change, from science to society: methodological Guide(2022) Aranaz Corral, Inmaculada; Castiñeiras García, Pedro; García Tartera, Francisco José; González Burgos, Elena María; Pérez Del Pozo, María Josefa; Rodríguez López, Blanca María; Sánchez Millas, María Del Pilar; Chumbo, Isabel; Exposto, José; Gonçalves, V; Silva, Elisabette; Greco, Michele; Milella, Luigi; Paternoster, Michele; Rizzo, Giovanna; Moraitis, Nikolaos; Moschovakou, Aikaterini Aloizia; Buyukkalay, NurgulThis methodological guide is the outcome of Erasmus + CTwoSEAS (Cambio climático: Ciencia, ética y sociedad) project carried out between 2019 and 2022 . In this project 5 european institutions were involved, Complutense University (coordinator of the project), Polytechnic Institute of Bragança (Portugal), SEV/IVEPE center (Greece), Akdeniz Univerity(Turkey) and Basilicata University (Italy). This methodological guide aims to support the teaching of the course Climate Change: From Science to Society in terms of the organisation of students' learning, the development of these learnings, and their evaluation. All of this will be focused on the competences that the students must acquire during their learning process. We are aware that, sometimes, the pedagogical training of university faculty staff outside the branches of education is scarce and, therefore, this guide will offer a myriad of methodological tools and strategies that can overcome some of these possible shortcomings. In the development of this methodological guide, we are mindful that the proposed methodologies to be used in each specific case are limited by the context of the course and the organisational context of each educational institution. Given the diverse nature of each educational institution and its conditions (physical resources, teacher training, budget, among others) it will be the task of the teachers of the course in each of the institutions to select the most appropriate methodology to their reality. The challenge of this methodological guide is to design working modalities and methodologies for both teachers and students that are appropriate for a standard student in the European Higher Education Area (EHEA) to achieve the skills that are proposed.- Project number: 277
Item Elaboración de casos clínicos como estrategia de conocimiento situado para alcanzar un aprendizaje profundo(2021) Garcimartín Álvarez, Alba; García Aguilar, Ana; Bocanegra De Juana, Aranzazu; González Burgos, Elena María; Gómez Oliver, Francisca; Guerra Guirao, José Antonio; Merino Martín, José Joaquín; Bedoya del Olmo, Luis Miguel; García García, Luis; Fernández Alfonso, María Soledad; Garcia Broncano, Rosario; Manzano Lista, Francisco Javier; Ureña Vacas, Isabel; Hernández Martín, MarinaLa elaboración de un caso clínico personalizado permite al estudiante vivenciar el conocimiento y la aplicación real e inmediata de la asignatura, aspecto crucial para reorientar su motivación y alcanzar un aprendizaje profundo. Item Risk of dementia among antidepressant elderly users: A population-based cohort analysis in Spain(Journal of Affective Disorders, 2024) Santandreu, Javier; Caballero, Francisco Félix; Gómez-Serranillos Cuadrado, María Pilar; González Burgos, Elena MaríaThe use of antidepressants with anticholinergic effects has been associated with an increased risk of dementia. However, the results published are contradictory. The aim of the study is to compare the risk of developing dementia in elderly who were prescribed tricyclic antidepressants (TCA) versus those who were prescribed selective serotonin reuptake inhibitors (SSRIs) and other antidepressants (OA). A prospective population-based cohort study was performed using the Spanish Database for Pharmacoepidemiological Research in Primary Care (BIFAP) data (from 2005 to 2018). The cohort study included 62,928 patients age ≥ 60 without dementia and with antidepressant long-term monotherapy. Patients were divided into exposure antidepressant groups based on ATC system [TCA, SSRIs users and OAs users]. The risk of dementia was calculated by Cox regression models, providing hazard ratios (HR) and 95 % confidence intervals. The Kaplan-Meier model was used for survival analysis. Chi2 test was used as association test. The results showed SSRI users had higher dementia risk than TCA users (HR = 1.864; 95%CI = 1.624–2.140). Moreover, OA users had also significant risk of dementia (HR = 2.103; 95%CI = 1.818–2.431). Several limitations are the variation of the trend in the prescription of antidepressants, the small number of patients that use some antidepressants, the lack of information related to the dose, or socioeconomic characteristics, the use of antidepressant drugs for other indications, or the therapeutic compliance. Our findings showed that older users of SSRI and OA have more risk of developing dementia than TCA elderly users. However, additional studies would be needed.Item Self-assembling, supramolecular chemistry and pharmacology of amphotericin B: Poly-aggregates, oligomers and monomers(Journal of Controlled Release, 2021) Raquel Fernández-García; Juan C. Muñoz-García; Matthew Wallace; Laszlo Fabian; González Burgos, Elena María; Gómez-Serranillos Cuadrado, María Pilar; Raposo González, Rafaela; Bolas Fernández, Francisco; Ballesteros Papantonakis, María De La Paloma; Anne Marie Healy; Yaroslav Z. Khimyak; Serrano López, Dolores RemediosAntifungal drugs such as amphotericin B (AmB) interact with lipids and phospholipids located on fungal cell membranes to disrupt them and create pores, leading to cell apoptosis and therefore efficacy. At the same time, the interaction can also take place with cell components from mammalian cells, leading to toxicity. AmB was selected as a model antifungal drug due to the complexity of its supramolecular chemical structure which can self-assemble in three different aggregation states in aqueous media: monomer, oligomer (also known as dimer) and poly-aggregate. The interplay between AmB self-assembly and its efficacy or toxicity against fungal or mammalian cells is not yet fully understood. To the best of our knowledge, this is the first report that investigates the role of excipients in the supramolecular chemistry of AmB and the impact on its biological activity and toxicity. The monomeric state was obtained by complexation with cyclodextrins resulting in the most toxic state, which was attributed to the greater production of highly reactive oxygen species upon disruption of mammalian cell membranes, a less specific mechanism of action compared to the binding to the ergosterol located in fungal cell membranes. The interaction between AmB and sodium deoxycholate resulted in the oligomeric and polyaggregated forms which bound more selectively to the ergosterol of fungal cell membranes. NMR combined with XRD studies elucidated the interaction between drug and excipient to achieve the AmB aggregation states, and ultimately, their diffusivity across membranes. A linear correlation between particle size and the efficacy/toxicity ratio was established allowing to modulate the biological effect of the drug and hence, to improve pharmacological regimens. However, particle size is not the only factor modulating the biological response but also the equilibrium of each state which dictates the fraction of free monomeric form available. Tuning the aggregation state of AmB formulations is a promising strategy to trigger a more selective response against fungal cells and to reduce the toxicity in mammalian cells.Item DNA-Based Authentication and Metabolomics Analysis of Medicinal Plants Samples by DNA Barcoding and Ultra-High-Performance Liquid Chromatography/Triple Quadrupole Mass Spectrometry (UHPLC-MS)(Plants, 2020) Sánchez Gómez-Serranillos, Marta; González Burgos, Elena María; Dulare Devi, Pradeep Divakar; Gómez-Serranillos Cuadrado, María PilarThere is growing interest for medicinal plants in the world drug market. Particularly, Matricaria recutita L., Valeriana officinalis L., Tilia spp., and Camellia sinensis (L.) Kuntze are some of the most consumed medicinal plants for treatment of minor health problems. Medicinal plants are seen as natural and safe; however, they can cause interactions and produce adverse reactions. Moreover, there is lack of consensus in medicinal plants regulation worldwide. DNA barcoding and UHPLC-MS technique are increasingly used to correctly identify medicinal plants and guarantee their quality and therapeutic safety. We analyzed 33 samples of valerian, linden, tea, and chamomile acquired in pharmacies, supermarkets, and herbal shops by DNA barcoding and UHPLC-MS. DNA barcoding, using matk as a barcode marker, revealed that CH1 sold as Camellia sinensis was Blepharocalyx tweediei, and sample TS2 sold as linden belong to Malvales. On the other hand, UHPLC-MS analysis revealed the presence of bioactive compounds (apigenin-7-glucoside, acetoxy valerenic acid, valerenic acid, epigallocatechin, and tiliroside). However, none of samples met minimum content of these active principles (except for valerenic acid in VF3) according to the European Medicines Agency (EMA) and Real Spanish Pharmacopeia. In conclusion, this study revealed the need to incorporate DNA barcoding and HPLC-MS techniques in quality controls of medicinal plants.Item Current knowledge on Parmelia genus: Ecological interest, phytochemistry, biological activities and therapeutic potential(2019) González Burgos, Elena María; Fernández Moriano, Carlos; Gómez-Serranillos Cuadrado, María PilarParmelia Acharius is one of the most representative genera within Parmeliaceae family which is the largest and the most widespread family of lichen-forming fungi. Parmelia lichens present a medium to large foliose thallus and they are distributed from the Artic to the Antartic continents, being more concentrated in temperate regions. According to its current description, the genus encompasses up to 41 different species and it is phylogenetically located within the Parmelioid clade (the largest group in the family). Interestingly, some of its species are among the most common epiphytic lichens in Europe such as Parmelia sulcata Taylor and Parmelia saxatilis (L.) Ach. The present work aims at providing a complete overview of the existing knowledge on the genus, from general concepts such as taxonomy and phylogeny, to their ecological relevance and biological interest for pharmaceutical uses. As reported, Parmelia lichens arise as valuable tools for biomonitoring environmental pollution due to their capacity to bioaccumulate metal elements and its response to acid rain. Moreover, they produce a wide array of specialized products/metabolites including depsides, depsidones, triterpenes and dibenzofurans, which have been suggested to exert promising pharmacological activities, mainly antimicrobial, antioxidant and cytotoxic activities. Herein, we discuss past and recent data regarding to the phytochemical characterization of more than 15 species. Even though the knowledge is still scarce in comparsion to other groups of organisms such as higher plants and other non-lichenized fungi. Reviewed works suggest that Parmelia lichens are worthy of further research for determining their actual possibilities as sources of bioactive compounds with potential therapeutic applications.Item HPLC isolation of antioxidant constituents from Xanthoparmelia spp(Journal of Pharmaceutical and Biomedical Analysis, 2010) Amo De Paz, Guillermo; Raggio Quílez, José; Gómez-Serranillos Cuadrado, María Pilar; Palomino Ruiz-Poveda, Olga María; González Burgos, Elena María; Carretero Accame, María Emilia; Crespo De Las Casas, Ana MaríaA chromatographic method is described for the purification and characterization of secondary lichen substances with biological activity. A simple reversed-phase high-performance liquid chromatography method with gradient elution has been developed that allows the determination and isolation of salazinic, usnic and stictic acids from lichen samples in a single run and the quantification of every acid in the tested extracts. The antioxidant activity of both the isolated compounds and the respective lichen belonging to Xanthoparmelia genus was determined by the Oxygen Radical Absorbance Capacity (ORAC) assay; their effect as free radical scavengers, effect on cell survival by the 3(4,5-dimethyltiazol-2-yl)-2,5-diphenyltetrazolium reduction assay and 2′,7′-dichlorofluorescin diacetate method were tested on U373 MG human astrocytome cell line. Both lichens extracts and all isolated compounds protected U373 MG cells from hydrogen peroxide-induced damage, suggesting that they could act as antioxidant agents in those neurodegenerative disorders associated with oxidative damage, such as Alzheimer's disease and Parkinson's disease.Item Estrategias de uso racional de medicamentos en personas mayores como mejora de la calidad de vida y de promoción del bienestar(2021) Garcimartín Álvarez, Alba; García Aguilar, Ana; Gómez Oliver, Francisca; Guerra Guirao, José Antonio; Merino Martín, José Joaquín; García García, Luis; González Burgos, Elena María; Fernández Alfonso, María Soledad; Bocanegra De Juana, Aranzazu; Bedoya del Olmo, Luis Miguel; Manzano Lista, Francisco Javier; Garcia Broncano, Rosario; Hernández Martín, Marina; Ureña Vacas, IsabelEl proyecto “Estrategias de uso racional de medicamentos en personas mayores como mejora de la calidad de vida y de promoción del bienestar” se basa en la elaboración y diseño de estrategias de prevención y mejora en torno al cumplimiento terapéutico, el uso racional del medicamento, y la identificación temprana de reacciones adversas a medicamentos, entre otros problemas relacionados con el medicamento. Este proyecto es una continuación del anterior ApS UCM 2019 “Identificación de problemas relacionados con el medicamento y estrategias de mejora en personas mayores”. En esta ocasión, y por la pandemia por COVID-19, este ApS será virtual, desarrollándose diversos talleres en formato de vídeo para dar formación a las personas mayores en materia de medicamento y que se centrarán en el tratamiento de las distintas patologías de la meta 3.4. de los ODS 2030, con el fin de aumentar la calidad de vida y el bienestar social de este colectivo. Esta actividad se integra en la docencia de las asignaturas de Farmacología General, y Farmacología y Farmacoterapia del Grado en Farmacia y del Doble Grado de Farmacia y Nutrición como estrategia de aprendizaje para consolidar y profundizar lo aprendido en estas materias.