Person: Torres García Denche, Jesús
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First Name
Jesús
Last Name
Torres García Denche
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Odontología
Department
Especialidades Clínicas Odontológicas
Area
Estomatología
Identifiers
9 results
Search Results
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Item Differences in platelet‐rich plasma composition influence bone healing(Journal of Clinical Periodontology, 2021) Al‐Hamed,; Abu‐Nada, Lina; Rodan, Rania; Sarrigiannidis, Stylianos; Ramirez‐Garcialuna, Jose Luis; Moussa, Hanan; Elkashty, Osama; Gao, Qiman; Tayebeh Basiri; Baca, Laura; Torres García Denche, Jesús; Rancán, Lisa; Simon D. Tran; Marie Lordkipanidzé; Mari Kaartinen; Zahi Badran; Faleh TamimiAim: Platelet-rich plasma (PRP) is an autologous blood-derived material that has been used to enhance bone regeneration. Clinical studies, however, reported inconsistent outcomes. This study aimed to assess the effect of changes in leucocyte and PRP (L-PRP) composition on bone defect healing. Materials and Methods: L-PRPs were prepared using different centrifugation methods and their regenerative potential was assessed in an in-vivo rat model. Bilateral critical-size tibial bone defects were created and filled with single-spin L-PRP, double-spin L-PRP, or filtered L-PRP. Empty defects and defects treated with collagen scaffolds served as controls. Rats were euthanized after 2 weeks, and their tibias were collected and analysed using micro-CT and histology. Results: Double-spin L-PRP contained higher concentrations of platelets than singlespin L-PRP and filtered L-PRP. Filtration of single-spin L-PRP resulted in lower concentrations of minerals and metabolites. In vivo, double-spin L-PRP improved bone healing by significantly reducing the size of bone defects (1.08 ± 0.2 mm3) compared to single-spin L-PRP (1.42 ± 0.27 mm3) or filtered L-PRP (1.38 ± 0.28 mm3). There were fewer mast cells, lymphocytes, and macrophages in defects treated with double-spin L-PRP than in those treated with single-spin or filtered L-PRP. Conclusion: The preparation method of L-PRP affects their composition and potential to regenerate bone.Item Split bone block technique: 4-month results of a randomised clinical trial comparing clinical and radiographic outcomes between autogenous and xenogeneic cortical plates(Int J Oral Implantol (Berl), 2021) Iglesias Velázquez, Óscar; Tresguerres, Francisco G F; Leco Berrocal, María Isabel; Fernández-Tresguerres Hernández-Gil, Isabel; López-Pintor Muñoz, Rosa María; Carballido, Jorge; López-Quiles Martínez, Juan; Torres García Denche, JesúsPurpose: To evaluate short-term clinical and radiographic outcomes of bone regeneration procedures using thin cortical porcine xenogeneic bone plates in combination with autogenous bone chips compared with thin autogenous cortical plates and autogenous bone chips. Materials and methods: A total of 19 patients (12 women and 7 men, mean age 58.24 ± 3.09 years) were randomly allocated to two different groups regarding surgical procedure: autogenous cortical plates (ACP group) and xenogeneic cortical plates (XCP group). Preoperative CBCT scans were performed for each patient. Surgical time and postoperative pain were recorded, as well as tissue healing and graft resorption after 4 months, then another surgical procedure was performed to place dental implants. Data were analysed using an analysis of covariance. Results: Twenty-one surgical procedures were performed on 19 patients (10 from the XCP group and 9 from the ACP group). The operative time was significantly lower in the XCP group (25.45 ± 3.88 minutes) than in the ACP group (44.10 ± 3.60 minutes). The XCP group also showed less pain, but not significantly less, than the ACP group. The graft resorption rate in the ACP and XCP groups was 2.03 ± 1.58% and 3.49 ± 2.38% respectively, showing no statistically significant difference. Conclusions: Despite the limited sample size and non-uniform distribution between the maxilla and mandible as surgical sites, the results suggest that XCP and ACP grafts are similar in terms of bone volume gain and graft resorption rate, with no significant differences in wound healing or complication rate. Nevertheless, the XCP group recorded lower pain levels and required significantly less operative time compared to the ACP group.Item The osteocyte: A multifunctional cell within the bone(Annals of anatomy, 2020) Torres García Denche, Jesús; López-Quiles Martínez, Juan; Hernández Vallejo, Gonzalo; Vega, Jose Antonio; Fernández-Tresguerres Hernández-Gil, IsabelThe knowledge of bone biology has largely changed in the last few decades. Osteocytes are multifunc- tional bone cells that are surrounded by mineralized bone matrix and for decades it was considered that they might be relatively inactive cells. However, nowadays it is known that osteocytes are highly active cells which are indispensable for the normal function of the skeleton, playing main roles in several physiological processes, both within and beyond the bone microenvironment. This review highlights and updates the current state of knowledge of the osteocyte and focuses on its roles in bone remodeling and mineral homeostasis, and also reviews its recently discovered endocrine function. Osteocytes secrete sclerostin (a protein that works as a negative regulator of bone mass), and FGF-23, the most important osteocyte-secreted endocrine factor, since it is able to regulate the phosphate metabolism. Moreover, osteocytes can act as mechanosensory cells, transforming the mechanical strain into chemical signal- ing towards the effector cells (osteoblasts and osteoclasts). Therefore, the osteocyte plays an important role in bone biology, specifically in the remodeling process, since it regulates both the osteoblast and osteoclast activity. Finally, the paper discusses the clinical application of the bone biology, updating the new therapies against bone-loss disorders.Item The role of cortical perforations in allogeneic block grafting for lateral augmentation in maxilla: A randomized clinical trial(Clinical Implant Dentistry and Related Research, 2021) Tresguerres, Francisco G. F. ç; Fernández-Tresguerres Hernández-Gil, Isabel; Isabel F. Tresguerres; Iglesias, Oscar; Leco Berrocal, María Isabel; Tamimi, Faleh; Torres García Denche, JesúsAbstract Background: The need of decortication on the recipient site remains unclear for bone regeneration. To our knowledge, there are no human clinical trials that studied the influence of decortication on cancellous allogeneic block grafting. Purpose: The aim of the present study is to evaluate the influence of perforating the cortex of the recipient site on cancellous allogeneic block graft integration and revas- cularization in the maxilla. Material and Methods: Twenty-six patients referred for lateral bone augmentation were included in this clinical trial. Patients received freeze-dried bone allograft can- cellous blocks obtained from the iliac crest; cortical perforations of the recipient bed were performed in the test group while in the control group it was left intact. After a 4-month healing period another surgery was performed to place dental implants, and a bone biopsy was collected using a trephine. All samples underwent micro-CT scans, and were processed for histomorphometric and immunohistochemical analysis. Implant survival comparisons were made using a repeated measures analysis of vari- ance (ANOVA) while all other variables were compared using the analysis of covari- ance (ANCOVA). Results: One hundred and nineteen implants were placed into 110 augmented sites. One hundred percent implant survival rate was reported during 24 months follow-up period. No differences were reported in bleeding on probing at 1 (5.6 vs 9%) and 2 years (13.2 vs 12.1%), probing pocket depth at 1 (3.4 ± 0.95 vs 3.6 ± 1.12 mm) and 2 years (3.8 ± 1.02 vs 4.1 ± 1.46 mm), and marginal bone loss at 1 (0.2 ± 0.52 vs 0.3 ± 0.57 mm) and 2 years (0.6 ± 0.91 vs 0.5 ± 0.87 mm). No statistically significant dif- ferences were found in the micro-CT and histomorphometric analysis in terms of newly formed bone (25.7 ± 11.2% vs 22.3 ± 9.7%), soft tissue (33.0 ± 14.7% vs 36.5 ± 15.7%), remnant allograft (39.3 ± 20.4% vs 41.2 ± 22.7%), and bone mineralization (57.2 ± 10.6% vs 53.8 ± 8.7%). Perforating the cortex of the recipient site had no sig- nificant effect on angiogenesis as shown by immunohistochemical analysis of CD34 positive blood vessels (39.21 ± 10.53/mm2 vs 34.16 ± 12.67/mm2). Conclusion: Cancellous allogeneic bone block grafts are a clinically acceptable alter- native for horizontal bone augmentation. Cortical perforations of the recipient site in the maxilla did not improve angiogenesis nor bone formation within the block graft.Item Application of propolis extract, nanovitamin C and nanovitamin E to prevent alveolar osteitis after impacted lower third molar surgery. A randomized, double-blind, split-mouth, pilot study(Med Oral Patol Oral Cir Bucal, 2021) González Serrano, José; López-Pintor Muñoz, Rosa María; Cecilia-Murga, Roberto; Torres García Denche, Jesús; Hernández Vallejo, Gonzalo; López-Quiles Martínez, JuanBackground: Propolis has anti-inflammatory, analgesic and healing properties. The purpose of this study was to determine whether a gel containing 2% of propolis extract, 0.2% of ascorbic acid and 0.2% of tocopherol acetate is effective in preventing surgical complications related to impacted lower third molar extractions. Material and methods: A randomized, double-blind, split-mouth study was performed. Fifteen patients were recruited who needed bilateral impacted lower third molar extractions with a similar surgical difficulty. A test or placebo gel was administered randomly inside post-extraction sockets. Each patient was instructed to apply the gel 3 times/day in the surgical wound for a week. After a month, the contralateral third molar was extracted, and the opposite gel applied. The following parameters were diagnosed/evaluated and then recorded: alveolar osteitis following Blum's criteria, swelling and trismus at day one, two, three and seven post-intervention, wound healing at day 7 post-intervention, and postoperative pain using a visual analog scale, as well as, the number of analgesic pill intake. Results: A total of twenty-six surgical procedures were performed in 13 patients (mean age 20.67±2 years). Alveolar osteitis was reported in 3 patients from the placebo group (23.1%) and none in the test group (0%) (p=0.25). No statistically significant differences were reported in swelling, trismus, wound healing or analgesic pill consumption between two groups. But statistically lower postoperative pain during the 7 days after surgical extractions was found according to visual analog scale in test group compared to the placebo group (p=0.007). No side effects were reported. Conclusions: The application of this gel may be effective in preventing alveolitis and thus reducing postoperative pain after impacted third molar extractions. More randomized clinical trials with larger sample are needed to confirm these results.Item Short‐term efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E on peri‐implant mucositis: A double‐blind, randomized, clinical trial(Journal of Periodontal Research, 2021) González Serrano, José; López-Pintor Muñoz, Rosa María; Serrano Valle, Julia; Torres García Denche, Jesús; Hernández Vallejo, Gonzalo; Sanz Martín, MarianoObjective: To determine the efficacy of a gel containing propolis extract, nanovitamin C and nanovitamin E as adjuvant to mechanical debridement in the treatment of peri- implant mucositis (PM). Background: Propolis has anti-inflammatory and antibacterial effect that may im- prove peri-implant health. Methods: A randomized, double-blind study was performed on patients with at least one implant with PM. Participants received a professional prophylaxis and were in- structed to use either test or a control gel as toothpaste three times/day for 1 month. Clinical and microbiological parameters were evaluated. PM resolution was considered in absence of bleeding on probing (BOP). Data were analysed with Mann-Whitney U, Wilcoxon signed-rank and chi-square tests. Results: Forty-six patients participated (23 in each group). After treatment, 26.1% of test patients showed complete PM resolution versus 0% in control group (p = .02). Significant reductions were observed in plaque index (p = .03), BOP (p = .04) and prob- ing depths (p = .027) in test compared with control group. The reduction in Tannerella forsythia was statistically greater in test than in control group at 1-month follow-up (p = .02). Porphyromonas gingivalis was statistically reduced in test group from baseline to 1-month follow-up (p = .05). Conclusion: Test gel clinically improved PM and showed certain antimicrobial effect after 1 month in comparison with control group. Further long-term clinical trials are required to confirm these results.Item Clinical and radiographic outcomes of allogeneic block grafts for maxillary lateral ridge augmentation: A randomized clinical trial(Clinical Implant Dentistry and Related Research, 2019) Tresguerres, Francisco G. F.; Cortes, Arthur R. G.; Hernández Vallejo, Gonzalo; Cabrejos‐Azama, Jatsue; Tamimi, Faleh; Torres García Denche, JesúsAbstract Background: A main drawback of bone block graft surgery is the resorption occurring in early stages of healing. To our knowledge, there are no studies comparing out- comes of freeze-dried bone allograft (FDBA) blocks with different architecture. Purpose: The aim of this work was to investigate different factors that can affect graft resorption and to compare the resorption rates of two different types of alloge- neic blocks, corticocancellous and cancellous. Materials and Methods: A randomized clinical trial was designed. Twenty-eight patients referred for onlay bone augmentation prior to implant placement were included in the study. Preoperative computerized tomography (CT) was taken for all patients. Patients received FDBA blocks of either cancellous or corticocancellous bone obtained from the iliac crest. After a 4-month follow-up, postoperative CT was taken. Then, another surgery was performed, with the purpose to place dental implants. The aforementioned groups were compared for bone resorption and implant outcome using analysis of covariance (ANCOVA) and repeated ANOVA mea- sures, respectively. Demographic data, trabecular bone density, and graft sites were also analyzed. Results: A total of 93 implants were placed in the augmented bone sites over 28 patients. A 100% survival rate was achieved during a mean follow-up period of 24 months in both groups. Higher bone resorption rate was found with cancellous bone grafts (29.2%±2.6) compared with corticocancellous grafts (19.3%±2.3). Moreover, higher resorption rates in patients with lower bone density (<185 Houns- field Units) (31.7% ± 3.1) and smokers (26.39% ± 2.3) were observed when compared with patients with higher bone density (>185 Hounsfield Units) (16.8% ± 2.1) and nonsmokers (22.1% ± 2.3), respectively. Conclusion: Within the limitations of this study, these findings indicate that both corticocancellous and cancellous FDBA grafts constitute a clinical acceptable alterna- tive for bone reconstruction, although cancellous grafts present higher resorption rates. Moreover, host factors such as patient's low bone density and smoking habits may also increase graft resorption rates.Item Implant treatment in pharmacologically immunosuppressed liver transplant patients: A prospective‐controlled study(Clinical Oral Implants Research, 2017) Paredes Rodríguez, Víctor Manuel; López-Pintor Muñoz, Rosa María; Torres García Denche, Jesús; de Vicente, Juan Carlos; Sanz Alonso, Mariano; Hernández Vallejo, GonzaloAbstract Objectives: The main objective of this prospective study was to evaluate the long-term outcome of implant therapy in liver transplant patients (LTP). The secondary goal was to assess several implant- and patient-dependent variables, such as peri-implantitis (PI), peri- implant mucositis (PIM), bone loss (BL), and immediate postoperative complications. Material and methods: Two groups, including 16 pharmacologically immunosup- pressed LTP and 16 matched controls, received 52 and 54 implants, respectively, be- tween 1999 and 2008. After evaluating the postoperative healing, a mean follow-up of more than 8 years was carried out, and radiographic, clinical, and periodontal pa- rameters were recorded to evaluate implant survival and implant- and patient- dependent outcomes. Results: The early postsurgical complications were similar in both groups. Implant sur- vival rate was 100% in the LTP group and 98.15% in the CG. PIM was diagnosed in 35.42% of the implants and 64.29% of the patients of LTP group (LTPG) and in 43.40% of the implants and 56.25% of the patients in the CG. PI was detected in 4.17% of the implants and 7.10% of the patients in the LTPG and in 9.43% of the implants and 18.80% of the patients in the CG. Conclusion: Pharmacologically immunosuppression in liver transplant patients was not a risk factor for implant failure, nor for the incidence of peri-implant diseases. Liver transplant is not a contraindication for dental implant treatment, although these pa- tients should be carefully monitored during follow-up care.Item Periosteal Pocket Flap technique for lateral ridge augmentation. A comparative pilot study versus guide bone regeneration(Annals of anatomy, 2022) Iglesias-Velázquez, Óscar; Rebeca Serrano Zamora; López-Pintor Muñoz, Rosa María; Francisco G F Tresguerres; Leco Berrocal, María Isabel; Meniz García, Cristina María; Fernández-Tresguerres Hernández-Gil, Isabel; Torres García Denche, JesúsBackground: Implant rehabilitation of posterior mandibular defects is frequently associated to a horizontal bone loss. There exist several regenerative techniques to supply this bone deficiency, one of which is the Periosteal Pocket Flap Technique (PPF) proposed by Steigmann et al. to treat small horizontal bone defects. The present study proposes a modification of this technique based on the concurrent use of PPF with the use of xenogeneic and autologous bone and Plasma Rich in Growth Factors (PRGF). The aim of this study is to evaluate clinical and radiographic outcomes of the PPF with the use of xenogeneic and autologous bone and PRGF in comparison with conventional Guided Bone Regeneration (GBR) procedures. Methods: Nine patients were enroled in the study (7 women and 2 men, mean age: 53 ± 2.74 years) and allocated to PPF or GBR. In both groups implant placement was performed simultaneously to bone regeneration. Preoperative CBCT scans were performed for each patient. Surgical time and postoperative pain were recorded, as well as tissue healing. Moreover, horizontal bone gain (mm), graft surface area (mm2) and graft volume (mm3) were evaluated. Results: Nine surgeries were performed: 6 PPF and 3 GBR. Regarding clinical outcomes, operative time was significative greater in GBR group than in PPF group (51.67 ± 3.51 min vs. 37 ± 5.69 min; p = 0.008). Postoperative pain was higher in GBR compared to PPF (p = 0.011). Regarding radiographical results, there were not significant differences in horizontal bone gain (PPF: 9.43 ± 1.8 mm; GBR: 9.28 ± 0.42 mm), surface area (PPF: 693.33 ± 118.73 mm2; GBR: 655.61 ± 102.43 mm2), and volume (PPF: 394.97 ± 178.72 mm3; GBR: 261.66 ± 118 mm3) between groups. Conclusions: This prospective study demonstrates that the combination of autograft/xenograft and PRGF in PPF technique is a simpler, cheaper, and faster technique than GBR technique for achieving moderate lateral bone augmentation in implant treatment. Future randomised clinical studies are needed to confirm the results.