Person: Pérez Díaz, Carmen
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First Name
Carmen
Last Name
Pérez Díaz
Affiliation
Universidad Complutense de Madrid
Faculty / Institute
Veterinaria
Department
Medicina y Cirugía Animal
Area
Medicina y Cirugía Animal
Identifiers
6 results
Search Results
Now showing 1 - 6 of 6
Item Efficacy of Medical Ozone as an Adjuvant Treatment in Dogs with Intervertebral Disc Protusions: A Retrospective Study(Animals, 2023) Portero Fuentes, Miriam; Villalonga Rodríguez, Luis; Hernández, Mercedes; Pérez Díaz, CarmenOzone-therapy is used in humans as a coadjutant treatment in intervertebral disc diseases due to its analgesic, anti-inflammatory and antioxidant effects. References in dogs are scarce and limited to clinical cases (intradiscal/paravertebral infiltrations). The aim of this study was to assess the use of medical ozone (MO) as an adjunctive treatment in dogs with intervertebral disc protrusions (Hansen Type II/Chronic). A retrospective study was conducted in dogs diagnosed with intervertebral disc protrusions by MRI/CT in which MO was used as an adjuvant therapy to conventional medical treatment. Neurological examination and quality of life (QL) at the beginning and end of study were recorded, as well as posology and possible side effects. A total of 21 patients of different breeds and sex with a mean age of 12 years were included in this study. Results showed pain relief (7 ± 3 days) and improvement of neurologic signs (11 ± 9 days) with a consequent increasement in QL (13 ± 9 days). Thirteen out of the twenty-one patients (62%) showed a complete remission of the clinical signs. No serious adverse effects were observed. Medical ozone could be a potential complementary therapy to medical treatment in dogs with intervertebral disc protrusions. Prospective studies are necessary.Item Pharmacokinetics of Sativex® in Dogs: Towards a Potential Cannabinoid-Based Therapy for Canine Disorders(Biomolecules, 2020) Fernández Trapero, María; Pérez Díaz, Carmen; Espejo Porras, Francisco; Lago Femia, Eva de; Fernández Ruiz, JavierThe phytocannabinoid-based medicine Sativex® is currently marketed for the treatment of spasticity and pain in multiple sclerosis patients and is being investigated for other central and peripheral pathological conditions. It may also serve in Veterinary Medicine for the treatment of domestic animals, in particular for dogs affected by different pathologies, including human-like pathological conditions. With the purpose of assessing different dosing paradigms for using Sativex in Veterinary Medicine, we investigated its pharmacokinetics when administered to naïve dogs via sublingual delivery. In the single dose arm of the study, adult Beagle dogs were treated with 3 consecutive sprays of Sativex, and blood samples were collected at 12 intervals up to 24 h later. In the multiple dose arm of the study, Beagle dogs received 3 sprays daily for 14 days, and blood samples were collected for 24 h post final dose. Blood was used to obtain plasma samples and to determine the levels of cannabidiol (CBD), ∆9-tetrahydrocannabinol (∆9-THC) and its metabolite 11-hydroxy-∆9-THC. Maximal plasma concentrations of both ∆9-THC (Cmax = 18.5 ng/mL) and CBD (Cmax = 10.5 ng/mL) were achieved 2 h after administration in the single dose condition and at 1 h in the multiple dose treatment (∆9-THC: Cmax = 24.5 ng/mL; CBD: Cmax = 15.2 ng/mL). 11-hydroxy-∆9-THC, which is mainly formed in the liver from ∆9-THC, was almost undetected, which is consistent with the use of sublingual delivery. A potential progressive accumulation of both CBD and ∆9-THC was detected following repeated exposure, with maximum plasma concentrations for both cannabinoids being achieved following multiple dose. Neurological status, body temperature, respiratory rate and some hemodynamic parameters were also recorded in both conditions, but in general, no changes were observed. In conclusion, this study demonstrates that single or multiple dose sublingual administration of Sativex to naïve dogs results in the expected pharmacokinetic profile, with maximal levels of phytocannabinoids detected at 1–2 h and suggested progressive accumulation after the multiple dose treatment.- Project number: 289
Item Virtualización e impresión 3D de modelos anatómicos aplicados a la docencia y planificación quirúrgica IV(2021) Pérez Díaz, Carmen; Rodríguez Quirós, Jesús; De La Morena García, Eva; Portero Fuentes, Miriam; Gaspar Simón, Ignacio de; Villar de Gracia, Ana; Taberneiro Auiget, Daniel; Aranzana Enriquez, Daniel; Bernardi Villavicencio, Cristina Item Clinical signs, diagnostic imaging and histopathology in a dog with granulomatous meningoencephalitis manifested as a polyneuropathy(Veterinary Record Case Reports, 2022) Benito Benito, Miguel; Portero Fuentes, Miriam; Manso Díaz, Gabriel; Sánchez Madonado, Belén; Pérez Díaz, CarmenAn 11-year-old, female, neutered labrador retriever with a history of chronic and progressive right hindlimb lameness and facial asymmetry was referred for brain and lumbosacral magnetic resonance imaging and cerebrospinal fluid analysis. Multifocal non-enhancing T2-weighted images of hyperintense lesions were observed in the caudate nuclei and medulla oblongata. The right oculomotor nerve was markedly enlarged and showed marked enhancement on T1-weighted images after contrast injection, and there was diffuse enlargement of the sciatic and femoral nerves in the right hindlimb. Cerebrospinal fluid analysis showed a mixed pleocytosis. Histopathology revealed granulomatous inflammation affecting the brain, oculomotor and pelvic limb nerves, consistent with a diagnosis of granulomatous meningoencephalomyelitis.- Project number: 282
Item Virtualización e impresión 3D de modelos anatómicos aplicados a la docencia en Anatomía y Cirugía Veterinaria III(2020) Pérez Díaz, Carmen; Gaspar Simón, Ignacio de; Rodríguez Quirós, Jesús; Villalonga Rodríguez, Luis; Portero Fuentes, Miriam; Bernardi Villavicencio, Cristina; Morena García, Eva de la; Hernández De Frutos, Sandra; Labrador Pérez, Ángela; García Pérez, EnriqueCreación y aplicación de modelos anatómicos en 3D en la docencia de asignaturas de anatomía y cirugía en el grado de veterinaria - Project number: 46
Item Creación de un modelo anatómico 3D y de realidad virtual para el aprendizaje de la anatomía veterinaria, la endoscopia digestiva alta y la planificación quirúrgica en el perro(2021) Rojo Salvador, Concepción; Corral Pumarega, Jose Luis; Sainz Rodríguez, Ángel; González Martínez, María Encina; Rodríguez Franco, Fernando; Gaspar Simón, Ignacio de; García-Sancho Téllez, Mercedes Guadalupe; Díaz-Regañón Fernández, David Rafael; Rodríguez Quirós, Jesús; Pérez Díaz, Carmen; Jiménez Socorro, Antonio Nicolás; Mateos Sanz, María Aranzazu; Mendaza De Cal, Rosa María; de la Morena García, EvaSe diseña y reconstruye en 3D un modelo anatómico del complejo esófago-estómago-duodeno del perro. El objetivo es disponer de un modelo impreso en 3D, así como de materiales interactivos para el aprendizaje y la evaluación del aparato digestivo en las asignaturas de anatomía, medicina interna y cirugía. Se logra disponer de un prototipo flexible y bastante realista en cuanto a forma, textura y color. El modelo impreso se utiliza en docencia: en las clases de anatomía para el estudio de las morfologías externa e interna y la topografía, comparando con el modelo natural; en endoscopia digestiva como modelo para el desarrollo de habilidades manuales en la práctica con estudiantes; en cirugía para la planificación y los abordajes quirúrgicos. El modelo de aprendizaje virtual aún no está a disposición de los estudiantes, se encuentra actualmente en realización. Contamos con un pdf interactivo y se está desarrollando un vídeo virtual simulando el recorrido del endoscopio a través del segmento digestivo de interés.